Rice Husk SiO&lt;sub&gt;2&lt;/sub&gt; (NPs) Supported-BO&lt;sub&gt;3&lt;/sub&gt;H&lt;sub&gt;3&lt;/sub&gt;:A Highly Active, Solvent-Free and Recyclable Catalyst to Dihydropyrimidin-2(1&lt;i&gt;H&lt;/i&gt;)ones- (Thiones) and Coumarin-3-Carboxylic Acid Synthesis

Khatavi, Santosh Y.; Kamanna, Kantharaju; Yamanappa, H.; Raghothama, Srinivasarao

doi:10.18520/cs/v117/i11/1828-1841

Cited by 2 publications

(1 citation statement)

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“…[3,4] Pyrimidines have wide spectrum activity against DNA and RNA viruses such as polio herpes viruses, diuretic, antitumor, anti HIV, cardiovascular, anticarcinogenic and anti-inflammatory. [5][6][7][8][9][10][11] They [5] can be used as antibacterial, anticancer, antifungal, and antiviral. [12][13][14][15] Dihydropyrimidines (DHPMs) can serve as antioxidant, and orally active antihypertensive agents.…”

Section: Introductionmentioning

confidence: 99%

Dihydropyrimidines as Precursors for Synthesizing of Oxoketene gem-Dithiol and 1,2-Dithiol-3-Thione, a Facile Synthesis and Convenient Reaction Transformations

2020

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In the present work the authors could synthesize the substrates oxoketene gem-dithols 5, ketene dithioacetal 6 and 1,2dithiol-3-thione 39 from compounds bearing both nucleus indole and dihydropyrimidines together due to their biological and pharmacological activities. In this paper, and as a result of biological and pharmacological activities of oxoketene gemdithiols, ketene dithioacetal and/or 1,2-dithiol-3-thione; we synthesized various derivatives of them via indole and dihydropyrimidine in the form of either condensed or fused derivatives. We used ecofriendly methods such as pure orange juice as a green solvent and as an acid catalyst in the same time to prepare, 1-[2-imino-4-(1H-indol-3-yl)-6-methyl-1,2,3,4tetrahydropyrimidin-5-yl]-ethan-1-one 4a and/or 1-[4-(1H-Indol-3-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl]ethan-1-one 4b. Subsequently, the substrate 4b was treated with different reagents to afford, 1-(4-(1H-indol-3-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,3-dimercaptoprop-2-en-1-one 5 and/or 1-(4-(1H-indol-3-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,3-bis(methylthio)prop-2-en-1-one 6. Compounds 5 and/or 6 were used as synthons to get various heterocyclic compounds such as 3-(4-(1H-indol-3-yl)-6-methyl-2-(piperidin-1-yl)-1,4-dihydropyrimidine-5-carbonyl)-2-thioxochroman-4-one 16 and/or 4'-(1H-indol-3-yl)-2-mercapto-6'-methyl-6-(methylthio)-2'-thioxo-1',2',3',4'-tetrahydro-[4,5'-bipyrimidine]-5-carbaldehyde 18. The newly synthesized compounds have been in vitro examined as antimicrobial agents, and some of them showed a promising activity. All newly synthesized compounds have been characterized by means of elemental analyses, IR, 1 H-NMR and MS.

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Section: Introductionmentioning

confidence: 99%

Dihydropyrimidines as Precursors for Synthesizing of Oxoketene gem-Dithiol and 1,2-Dithiol-3-Thione, a Facile Synthesis and Convenient Reaction Transformations

2020

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Synthesis of bioactive scaffolds catalyzed by agro-waste-based solvent medium

Kamanna

Amaregouda

2022

Physical Sciences Reviews

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The backbone of synthetic organic chemistry is the formation of carbon–carbon and carbon–heteroatom bonds. Scientists are actively working to develop new methods of bond-forming reactions because it is one of the most useful tools for the development of structurally diverse molecular entities. On the other hand, scientists are constantly discovering chemical processes to make them more sustainable in order to avoid the ever-increasing chemical emission associated with hazards to the environment. Thus, the development of greener catalytic reactions demonstrated a massive uptick in the ability to carry out carbon–carbon and carbon–heteroatom bond-forming reactions under environmentally friendly and simple reaction conditions. Various approaches are demonstrated, namely, solvent-free, microwave irradiation, ionic liquids, ball milling, ultrasound, one-pot, and aqueous-mediated methods under green chemistry protocol. Agro-waste is the postharvest part or agricultural residues derived from various agricultural activities, which has diverse scope and applications. The use of this agro-waste is an eco-friendly and cost-effective process of waste management. Appropriate and optimal utilization of these waste by-products is one of the major challenges in the present days. The recent trend around the globe is to transform waste into wealth concepts to achieve various applications. Agro-waste-derived ashes and extracted medium are successfully studied recently as a heterogeneous- or homogenous-based catalyst in various organic transformations. Agro-waste-derived catalysts are easily available, cost-effective, simple to prepare, nontoxic, easy to handle, biodegradable, and more environmentally benign. This article focuses more on a few instances of agro-waste-based homogeneous and heterogeneous organic synthesis, especially those used in the construction of bioactive molecule synthesis via C–C and C–X bond formation reactions are discussed. The compiled literature in this article is based on keywords used in the search engine on “agro-waste-based catalyst for organic transformations”, and review articles published on this topic, future scope, and summary are discussed.

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Rice Husk SiO<sub>2</sub> (NPs) Supported-BO<sub>3</sub>H<sub>3</sub>:A Highly Active, Solvent-Free and Recyclable Catalyst to Dihydropyrimidin-2(1<i>H</i>)ones- (Thiones) and Coumarin-3-Carboxylic Acid Synthesis

Cited by 2 publications

References 0 publications

Dihydropyrimidines as Precursors for Synthesizing of Oxoketene gem-Dithiol and 1,2-Dithiol-3-Thione, a Facile Synthesis and Convenient Reaction Transformations

Dihydropyrimidines as Precursors for Synthesizing of Oxoketene gem-Dithiol and 1,2-Dithiol-3-Thione, a Facile Synthesis and Convenient Reaction Transformations

Synthesis of bioactive scaffolds catalyzed by agro-waste-based solvent medium

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