Rich oleocanthal and oleacein extra virgin olive oil and inflammatory and antioxidant status in people with obesity and prediabetes. The APRIL study: A randomised, controlled crossover study

Ruiz-García, Ignacio; Ortiz-Flores, Rodolfo; Badia, Rocío; García-Borrego, Aránzazu; García-Fernández, María; Lara, Estrella; Martín-Montañez, Elisa; García‐Serrano, Sara; Valdés, Sergio; Gonzalo, Montserrat; Tapia, María José; Fernández‐García, José Carlos; Sánchez‐García, Alicia; Muñoz-Cobos, Francisca; Calderon-Cid, Miguel; El-Bekay, Rajaa; Covas, Marı́a-Isabel; Rojo-Martínez, Gemma; Olveira, Gabriel; Romero-Zerbo, Silvana Y.; Bermúdez‐Silva, Francisco Javier

doi:10.1016/j.clnu.2023.06.027

Cited by 15 publications

(6 citation statements)

References 35 publications

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“…The study found that the only olive oil lacking beneficial effects on platelet aggregation was the one without (-)-oleacein and (-)-oleocanthal. Additionally, another study demonstrated that treatment with VOO rich in (-)-oleocanthal and (-)-oleacein substantially improved the oxidative and inflammatory status in people with obesity and prediabetes [145], in line with the results obtained in preclinical studies [146].…”

Section: Clinical Evidence On the Bioactivities Of Key Phenolic Molec...mentioning

confidence: 52%

Anti-Cancer, Anti-Angiogenic, and Anti-Atherogenic Potential of Key Phenolic Compounds from Virgin Olive Oil

Marrero,

Quesada,

Martínez-Poveda

et al. 2024

Nutrients

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The Mediterranean diet, renowned for its health benefits, especially in reducing cardiovascular risks and protecting against diseases like diabetes and cancer, emphasizes virgin olive oil as a key contributor to these advantages. Despite being a minor fraction, the phenolic compounds in olive oil significantly contribute to its bioactive effects. This review examines the bioactive properties of hydroxytyrosol and related molecules, including naturally occurring compounds (-)-oleocanthal and (-)–oleacein, as well as semisynthetic derivatives like hydroxytyrosyl esters and alkyl ethers. (-)-Oleocanthal and (-)–oleacein show promising anti-tumor and anti-inflammatory properties, which are particularly underexplored in the case of (-)–oleacein. Additionally, hydroxytyrosyl esters exhibit similar effectiveness to hydroxytyrosol, while certain alkyl ethers surpass their precursor’s properties. Remarkably, the emerging research field of the effects of phenolic molecules related to virgin olive oil on cell autophagy presents significant opportunities for underscoring the anti-cancer and neuroprotective properties of these molecules. Furthermore, promising clinical data from studies on hydroxytyrosol, (-)–oleacein, and (-)–oleocanthal urge further investigation and support the initiation of clinical trials with semisynthetic hydroxytyrosol derivatives. This review provides valuable insights into the potential applications of olive oil-derived phenolics in preventing and managing diseases associated with cancer, angiogenesis, and atherosclerosis.

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Section: Clinical Evidence On the Bioactivities Of Key Phenolic Molec...mentioning

confidence: 52%

Anti-Cancer, Anti-Angiogenic, and Anti-Atherogenic Potential of Key Phenolic Compounds from Virgin Olive Oil

Marrero,

Quesada,

Martínez-Poveda

et al. 2024

Nutrients

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“…In a randomized study that included patients with prediabetes and obesity, two groups were administered different oils: one group consumed oil enriched with oleocanthal and oleacein, while the other group consumed standard oil. The outcome of this study demonstrated that the group consuming the oleocanthal-enriched oil experienced improvements in their inflammatory profile and oxidative condition, along with a reduction in interferon γ levels (IFNγ) [8].…”

Section: Oleocanthal and Inflammationmentioning

confidence: 98%

“…Notably, recent studies have shown that extra virgin olive oil with elevated levels of oleocanthal and oleacein (phenolic compounds), in comparison to standard olive oil, not only enhances the management of obesity and prediabetes but also contributes to an improved inflammatory and oxidative profile [8].…”

Section: Introductionmentioning

confidence: 99%

Oleocanthal, an Antioxidant Phenolic Compound in Extra Virgin Olive Oil (EVOO): A Comprehensive Systematic Review of Its Potential in Inflammation and Cancer

González-Rodríguez,

Ait Edjoudi,

Cordero-Barreal

et al. 2023

Antioxidants

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Background: The Mediterranean diet is linked to various health benefits, especially the consumption of olive oil as a key component. Multiple studies highlight its advantages, particularly due to its fatty acid composition and additional components like phenolic compounds. A significant antioxidant compound, oleocanthal, known for its antioxidant properties, has gained attention in the pharmaceutical industry for its anti-inflammatory and antiproliferative effects. It shows promise in addressing cardiovascular diseases, metabolic syndrome, and neuroprotection. This systematic review aims to evaluate the existing literature on oleocanthal, examining its role in biological processes and potential impact on conditions like inflammation and cancer. Methods: We performed several searches in PubMed (MEDLINE), Web of Science (WOS), and Cochrane based on the terms “Oleocanthal”, “Cancer”, and “Inflammation”. The inclusion criteria were as follows: studies whose main topics were oleocanthal and cancer or inflammation. On the other hand, the exclusion criteria were studies that were not focused on oleocanthal, reviews, or editorial material. Given that these findings are explanatory rather than derived from clinical trials, we refrained from employing methods to assess potential bias. This systematic review did not receive any external funding. Results: We found 174 records from these searches, where we discarded reviews and editorial material, duplicated articles, and 1 retracted article. Finally, we had 53 reports assessed for eligibility that were included in this review. Discussion: OC exhibits promising therapeutic potential against both inflammation and cancer. We addressed its ability to target inflammatory genes and pathways, offering potential treatments for conditions like rheumatic diseases by regulating pathways such as NF-kB and MAPK. Additionally, OC’s anticancer properties, particularly its notable inhibition of c-Met signaling across various cancers, highlight its efficacy, showcasing promise as a potential treatment.

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“…In addition, OC was also reported to exert beneficial effects in experimental models of Alzheimer disease [7] and collagen-induced arthritis [8]. Up to now, there have been very few clinical trials aimed at investigating the beneficial effects of OC in human beings [5,9].…”

Section: Introductionmentioning

confidence: 99%

Oleocanthal Protects C2C12 Myotubes against the Pro-Catabolic and Anti-Myogenic Action of Stimuli Able to Induce Muscle Wasting In Vivo

De Stefanis,

Balestrini,

Costelli

2024

Nutrients

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Oleocanthal (OC) is a monophenol of extra-virgin olive oil (EVOO) endowed with antibiotic, cardioprotective and anticancer effects, among others, mainly in view of its antioxidant and anti-inflammatory properties. OC has been largely investigated in terms of its anticancer activity, in Alzheimer disease and in collagen-induced arthritis; however, the possibility that it can also affect muscle biology has been totally overlooked so far. This study is the first to describe that OC modulates alterations induced in C2C12 myotubes by stimuli known to induce muscle wasting in vivo, namely TNF-α, or in the medium conditioned by the C26 cachexia-inducing tumor (CM-C26). C2C12 myotubes were exposed to CM-C26 or TNF-α in the presence or absence of OC for 24 and 48 h and analyzed by immunofluorescence and Western blotting. In combination with TNF-α or CM-C26, OC was revealed to be able to restore both the myotube’s original size and morphology and normal levels of both atrogin-1 and MuRF1. OC seems unable to impinge on the autophagic–lysosomal proteolytic system or protein synthesis. Modulations towards normal levels of the expression of molecules involved in myogenesis, such as Pax7, myogenin and MyHC, were also observed in the myotube cultures exposed to OC and TNF-α or CM-C26. In conclusion, the data presented here show that OC exerts a protective action in C2C12 myotubes exposed to TNF-α or CM-C26, with mechanisms likely involving the downregulation of ubiquitin–proteasome-dependent proteolysis and the partial relief of myogenic differentiation impairment.

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Rich oleocanthal and oleacein extra virgin olive oil and inflammatory and antioxidant status in people with obesity and prediabetes. The APRIL study: A randomised, controlled crossover study

Cited by 15 publications

References 35 publications

Anti-Cancer, Anti-Angiogenic, and Anti-Atherogenic Potential of Key Phenolic Compounds from Virgin Olive Oil

Anti-Cancer, Anti-Angiogenic, and Anti-Atherogenic Potential of Key Phenolic Compounds from Virgin Olive Oil

Oleocanthal, an Antioxidant Phenolic Compound in Extra Virgin Olive Oil (EVOO): A Comprehensive Systematic Review of Its Potential in Inflammation and Cancer

Oleocanthal Protects C2C12 Myotubes against the Pro-Catabolic and Anti-Myogenic Action of Stimuli Able to Induce Muscle Wasting In Vivo

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