Objectives Pair-matching with random allocation in prospective controlled trials represents a novel and highly rigorous design. First use of the design can be traced to medicine (in 1926) and criminology and the social sciences more generally (in 1935). Beginning with these trials, we examine the subsequent history of matchedpair RCTs (randomized controlled trials), and related attention to stratification prior to randomization, in both criminology and medicine over almost a century to illustrate shared interest in the design's advantages and disadvantages.
MethodsWe draw upon a wide range of historical and contemporary sources, including historical archives and writings on the first trials in criminology and medicine, prior reviews of RCTs and matched-pair RCTs, and searches of selected databases.
ResultsThe first trials draw attention to key factors that remain central to contemporary use, including concerns about covariate imbalance when randomization is used on its own, potential to improve study power when matching is effective, and the ability to deal with differential attrition in follow-ups. The evolution of the design also shows that the single most important application of matched-pair RCTs is when the units are clusters or places.
ConclusionsOver the 20th and 21st centuries, criminology and medicine have continued to wrestle with methodologies to most efficiently and robustly compare like with like. Both, in this setting, have turned to matched-pair randomization, though less often than its advocates would like. It is this and other shared interests between criminology/social sciences and medicine/public health, including a movement toward evidence-based policy and practice, that help us reimagine possibilities for advancing knowledge and improving public policy.