Ricinoleic acid effect on the electrical activity of the small intestine in rabbits.

Mathias, John R.; Martin, Jay F.; Burns, Theodore W.; Carlson, Gerald M.; Shields, R.

doi:10.1172/jci108975

Cited by 69 publications

(31 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although some groups observed an inhibition of water and electrolyte absorption (12)(13)(14), others found an activation of ion secretory processes by ricinoleid acid (15). In addition to effects of ricinoleic acid on intestinal ion transport and water flux, evidence has been provided that ricinoleic acid can directly affect intestinal motility (16)(17)(18)(19). Whether these effects are mediated by the enteric nervous system or are direct effects on intestinal smooth muscle remained unclear.…”

mentioning

confidence: 99%

Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP ₃ receptors

Tunaru

Althoff

Nüsing

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

181

127

View full text Add to dashboard Cite

Castor oil is one of the oldest drugs. When given orally, it has a laxative effect and induces labor in pregnant females. The effects of castor oil are mediated by ricinoleic acid, a hydroxylated fatty acid released from castor oil by intestinal lipases. Despite the wide-spread use of castor oil in conventional and folk medicine, the molecular mechanism by which ricinoleic acid acts remains unknown. Here we show that the EP 3 prostanoid receptor is specifically activated by ricinoleic acid and that it mediates the pharmacological effects of castor oil. In mice lacking EP 3 receptors, the laxative effect and the uterus contraction induced via ricinoleic acid are absent. Although a conditional deletion of the EP 3 receptor gene in intestinal epithelial cells did not affect castor oil-induced diarrhea, mice lacking EP 3 receptors only in smooth-muscle cells were unresponsive to this drug. Thus, the castor oil metabolite ricinoleic acid activates intestinal and uterine smooth-muscle cells via EP 3 prostanoid receptors. These findings identify the cellular and molecular mechanism underlying the pharmacological effects of castor oil and indicate a role of the EP 3 receptor as a target to induce laxative effects.G-protein coupled receptor | peristalsis | Ricinus communis | PGE 2

show abstract

mentioning

confidence: 99%

Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP ₃ receptors

Tunaru

Althoff

Nüsing

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

181

127

View full text Add to dashboard Cite

show abstract

“…Our data demonstrate that low levels of distension locally stimulate contractile activity. We did not see any of the long migrating spike bursts as described by Mathias et al (1978) or the groups of migratory spike bursts as described by Atchison et al (1978). Our data suggest that the major effect of these secretagogues on the small bowel is that they induce a larger intraluminal volume and local mechanical stimulation of motility rather than a specific direct motility effect to produce catharsis.…”

Section: Discussionmentioning

confidence: 48%

Effects of intestinal secretagogues and distension on small bowel myoelectric activity in fasted and fed conscious dogs

Melo

Summers

Thompson

et al. 1981

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. Defined jejunal segments were perfused with solutions of bile salts and of ricinoleic acid during fasting and after feeding in two groups of conscious dogs, one with the segment in continuity, and the other with a Thiry-Vella loop. Myoelectric activity was recorded from chronically implanted electrodes on the jejunal segment and also from the proximal and distal in situ bowel.2. The results in both groups were identical. During fasting, migrating complexes were present in the segment, but were replaced by intermittent spike activity during chenodeoxycholate without and with ricinoleic acid perfusion. After food, when migrating complexes were replaced by intermittent spike activity, none of the solutions produced any consistent effect.3. In fasted animals, low levels of distension (15 mmHg) interrupted the migrating complexes in the segment and induced intermittent spike activity which was similar to that seen with the secretagogues. The migrating complexes in the main bowel continued during distension. In fed animals, spike activity increased in the segment during distension at 25 mmHg and decreased in the main bowel. In both groups, distension of the segment to pressures between 37-5 and 50 mmHg abolished spike activity both in the distended segment and the main bowel in fasted and fed states, and, in fasted dogs, migrating complexes were also abolished.4. These results demonstrate that the inhibitory intestino-intestinal reflex is mediated through extrinsic nerves and does not require an intact myenteric plexus, whereas the altered myoelectric activity induced by secretagogues is a local effect and does not spread to adjacent bowel through either intrinsic or extrinsic neural pathways. It seems likely that the local motor effect of secretagogues is a result of net secretion, producing distension to pressures below the threshold required to activate the intestino-intestinal reflex.t Present address:

show abstract

“…Repetitive propagated bursts of contrac tions (RBAPs) or minute rhythm occur in normal small intestine [Rolemberg-Lessa et al, 1981] but their presence is enhanced in various experimental diarrheal diseases [Sninsky et al, 1985;Mathias, et al, 1978]. In patients with secretory diarrhea, the inci dence of RBAPs was found to be increased from 0.2 to more than 2.2 bursts/h [Vantrap pen et al, 1986].…”

Section: Abnormalities O F the MMC Patternmentioning

confidence: 99%

Role of Motility in Pathogenesis of Constipation and Diarrhea

Buéno¹,

Frexinos²,

Fioramonti³

1988

Pharmacology

View full text Add to dashboard Cite

Several attempts have been made in order to classify the gastrointestinal motility disorders; they are mainly based upon the type of disorder in transit and the region of the gastrointestinal tract affected. Many digestive motor disturbances do not constitute entities, but are pathophysiologic mechanisms that may contribute to the production of symptoms and signs of various diseases. The abnormal interdigestive motility pattern or the migrating motor complex often corresponds to the absence of phase 3 and several observations strongly suggest that this disordered motility pattern is the cause rather than the consequence of intestinal bacterial overgrowth. Disturbances of colonic motility are often associated with diarrhea; however, the nature of motor alterations depends on the diarrheal disease (episodic, continuous with or without pain). Finally, both gastrointestinal and colonic motor disturbances may contribute to the pathogenesis of constipation and diarrhea; however, several findings suggest that colonic motor alterations are the consequence rather than the cause of changes in bowel habits.

show abstract

Ricinoleic acid effect on the electrical activity of the small intestine in rabbits.

Cited by 69 publications

References 15 publications

Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP ₃ receptors

Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP ₃ receptors

Effects of intestinal secretagogues and distension on small bowel myoelectric activity in fasted and fed conscious dogs

Role of Motility in Pathogenesis of Constipation and Diarrhea

Contact Info

Product

Resources

About

Ricinoleic acid effect on the electrical activity of the small intestine in rabbits.

Cited by 69 publications

References 15 publications

Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP 3 receptors

Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP 3 receptors

Effects of intestinal secretagogues and distension on small bowel myoelectric activity in fasted and fed conscious dogs

Role of Motility in Pathogenesis of Constipation and Diarrhea

Contact Info

Product

Resources

About

Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP ₃ receptors

Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP ₃ receptors