Rickettsial ehrlichial and bartonella infections of the myocardium and pericardium

Shah, Sanjiv S.; McGowan, Joseph P.

doi:10.2741/995

Cited by 26 publications

(22 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(Weil's disease); Rickettsia spp. (Rocky Mountain or Mediterranean spotted fever among others) and Orientia tsutsugamushi (scrub typhus) and Coxiella burnetii 26 (Q-fever). Due to the geographical distribution of these diseases, Lyme disease and Q-fever are currently the most important.…”

Section: Aetiology and Pathophysiologymentioning

confidence: 99%

Myocarditis and the military patient

et al. 2015

View full text Add to dashboard Cite

Myocarditis, simply defined as inflammation of the heart muscle, is a commonly encountered cardiac disease in primary and secondary care, both in the UK and on Operational deployments. In the UK Armed Forces, myocarditis results in deaths as well as the premature termination of military careers on medical grounds. The aetiology is usually the result of a number of infectious aetiologies with viruses being the most common pathogens in the vast majority of cases. However, it may also be the result of autoimmune activation, chemical or pharmacological toxins, environmental insult or hypersensitivity reactions. Particular aetiologies that are more likely to be seen in a military population are discussed and include certain infections, smallpox vaccine, and hyperthermia and hypothermia. The clinical features can be highly variable ranging from an asymptomatic infection to fulminant heart failure. Features pertinent to the military doctor, including the natural history, investigative modalities and management strategies, with a particular emphasis on the occupational impact of myocarditis in the UK Armed Forces are reviewed.

show abstract

Section: Aetiology and Pathophysiologymentioning

confidence: 99%

Myocarditis and the military patient

et al. 2015

View full text Add to dashboard Cite

show abstract

“…However, acute hepatitis, sometimes with granulomatous appearance, always due to the endothelial cell damage, is considered a rare occurrence. 22,29,30 Other possible complications as encephalitis, 14,22,31-33 myocarditis 22,34,35 and pneumonia 22,36 are considered rare. In our case, the rapid onset of a MODS/MOF and the delayed appearance of cutaneous rash, together with the absence of the typical tache noire, certainly delayed the identification of the disease.…”

Section: Methods Of Researchmentioning

confidence: 99%

“…23 Multiple organ failure as onset of Mediterranean spotted fever days after symptoms' onset. [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] Other techniques, as isolation of bacteria and/or molecular polymerase chain reaction (PCR) to genome identification, which can be performed on blood, skin biopsies and ticks, are not routinely used because of their complexity and costs. Therefore, in clinical practice, they are reserved only in cases of extremely high clinical suspicion with all the other tests proving negative.…”

Section: Methods Of Researchmentioning

confidence: 99%

Multiple organ failure as onset of Mediterranean spotted fever: a review based on a case

et al. 2016

View full text Add to dashboard Cite

Mediterranean spotted fever (MSF) is an infectious disease endemic in the southern regions of Italy, with an incidence of about 400 cases/year. The bacteria responsible of the disease is Rickettsia conorii, transmitted to humans by Rhipicephalus sanguineus, the common dog tick. The infection usually manifests with a characteristic symptomatologic triad: fever, exanthema and the so called tache noire, which is the typical eschar at the site of the tick bite. Immunoglobulin M (IgM) and IgG enzymelinked immunosorbent assay and the gold standard micro-immunofluorescent assay, allow serological diagnosis. We report the case of a man suffering from MSF, whose atypical presentation and false-negative diagnostic tests delayed consistently diagnosis and therapy. Afterwards we review the literature about this topic. Contributions: PM and AS studied the case, reviewed literature and wrote the paper; AB, TC and GP studied the case; AD'A and CC studied the case and reviewed literature; AC coordinated the study group, reviewed literature and wrote the paper.Conflict of interest: the authors declare no potential conflict of interest.

show abstract

“…[2][3][4] The cardiotropic viruses adenovirus, enterovirus, Epstein-Barr virus, human herpes virus 6, parvovirus B19 (B19V) and cytomegalovirus, are common cough viruses. 2,5 Although up to 90% of people will catch one or more of these viruses in their life without getting their heart affected, only a selected few develop clinical symptoms.…”

mentioning

confidence: 99%

Serological and Molecular Biological Studies of Parvovirus B19, Coxsackie B Viruses, and Adenoviruses as Potential Cardiotropic Viruses in Bulgaria

Ivanova¹,

Angelova²,

Stoyanova³

et al. 2016

Folia Medica

View full text Add to dashboard Cite

Background: Infl ammatory diseases of the heart (myocarditis, pericarditis) are commonly caused by viruses. Among the human cardiotropic viruses, parvovirus B19, Coxsackie B viruses, and adenoviruses play a leading role. Aim: The aim of the present study was to determine the presumptive causative role of parvovirus B19, Coxsackie B viruses, and adenoviruses in the development of myocarditis, pericarditis and dilated cardiomyopathy by demonstrating the presence of specifi c antiviral antibodies or viral DNA in patients' serum samples. Materials and methods:We tested serum samples collected between 2010 and 2014 from 235 patients with myocarditis (n=108), pericarditis (n=79), myopericarditis (n=19), dilated cardiomyopathy (n=7), and fever of unknown origin accompanied by cardiac complaints (n=22). The mean age of patients with the standard deviation was 33 ± 18 years. Serological and molecular methods (ELISA for specifi c IgM/ IgG antibodies to parvovirus B19 and IgM antibodies to Coxsackie B viruses and adenoviruses, and PCR for detection of parvovirus B19 in serum samples, respectively) were used in the study. Results: Of all tested 235 serum samples, in 60 (25.5%) positive results for at least one of the three tested viruses were detected. Forty out of these 235 serum samples (17%) were Coxsackie B virus IgM positive. They were found in 17% (18/108) of the patients with myocarditis, in 15% (12/79) of those with pericarditis, in 16% (3/19) of those with myopericarditis and in 32% (7/22) in those with fever of unknown origin. The 63 Coxsackie B virus IgM negative patient's serum samples were tested by ELISA for presence of adenovirus IgM antibodies. Such were found in 4 patients with pericarditis and in 2 patients with fever of unknown origin. Every IgM negative sample (n=189) for Coxsackie B and adenovirus was further tested by ELISA for parvovirus B19 IgM/IgG antibodies. B19-IgM antibodies were detected in 14 patients (7.4%). The percentages for B19-IgM antibodies was 8% (7/90), 5% (3/63) and 31% (4/13) in the patients aff ected with myocarditis, pericarditis, and fever of unknown origin, respectively. Protective B19-IgG antibodies were found in 108 (57%) of the samples. A B19-PCR signal was detected in all the patients who were B19-IgM positive, and in only 1 patient with positive B19-IgG result, the latter presenting with dilated cardiomyopathy.Conclusion: The present study shows the involvement of Coxsackie B, parvovirus B19 and adenoviruses in the development of infl ammatory diseases of the heart (myocarditis and pericarditis). It is the fi rst ever study in the country that simultaneously analyzes the prevalence of the three major human cardiotropic viruses. BACKGROUND

show abstract

Rickettsial ehrlichial and bartonella infections of the myocardium and pericardium

Cited by 26 publications

References 24 publications

Myocarditis and the military patient

Myocarditis and the military patient

Multiple organ failure as onset of Mediterranean spotted fever: a review based on a case

Serological and Molecular Biological Studies of Parvovirus B19, Coxsackie B Viruses, and Adenoviruses as Potential Cardiotropic Viruses in Bulgaria

Contact Info

Product

Resources

About