Ridge-Shaped Macula in Young Myopic Patients and Its Differentiation From Typical Dome-Shaped Macula in Elderly Myopic Patients

Xu, Xiaoyan; Fang, Yuxin; Jonas, Jost B.; Du, Ran; Shinohara, Kosei; Tanaka, Noriko; Yokoi, Tae; Onishi, Yuka; Uramoto, Kengo; Kamoi, Koju; Yoshida, Takeshi; Ohno‐Matsui, Kyoko

doi:10.1097/iae.0000000000002395

Cited by 31 publications

(52 citation statements)

References 27 publications

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“…Thus, it is possible that our patients were within the spectrum of ridge-shaped macula. However, there were several differences between the present study and the study by Xu et al [13]. In the latter, ridge-shaped maculae were noted in 9.2% of young subjects with myopia, an incidence that was markedly higher than that in our patients.…”

Section: Discussioncontrasting

confidence: 94%

“…Thus, this condition was considered as a distinct entity and labeled as "ridge-shaped macula." The authors suggested that ridge-shaped macula may be due to a folding of Bruch's membrane at the posterior pole, potentially caused by asymmetrical enlargement of that membrane in the equatorial region [13]. It is noteworthy that all the DSMs in our patients were also observed only on vertical OCT scan.…”

Section: Discussionmentioning

confidence: 57%

“…More recently, Xu et al reported DSM in young subjects with high myopia [13]. In their study, 17 eyes exhibited macular elevation.…”

Section: Discussionmentioning

confidence: 80%

“…Although almost all previously reported DSM cases were found in the adult population [1, 3-5, 7, 8, 11, 14], some were recorded in children or adolescents [10,12,13]. In a study by Errera et al, DSM was noted in a 12-year-old subject with congenital stationary night blindness [10].…”

Section: Discussionmentioning

confidence: 99%

“…The evaluation of DSM in affected subjects may provide useful data on the condition's origin. However, since previous studies have mainly incorporated data from adults [1][2][3][4][7][8][9][10][11], limited knowledge exists regarding the characteristics of DSM in children or adolescents [10,12,13].…”

Section: Introductionmentioning

confidence: 99%

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Dome-shaped macula in children and adolescents

Shin

Park

2020

PLoS ONE

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We sought to evaluate the incidence and characteristics of dome-shaped macula (DSM) in children and adolescents with myopia. Methods A retrospective review of medical records was performed to identify subjects who were younger than 19 years with myopia of −3.0 diopters or greater. The results of optical coherence tomography images were analyzed to identify DSM. The height and diameter of the dome were measured. Age, best-corrected visual acuity (BCVA), and refractive error of study participants who exhibited DSM were compared with those of patients who did not. Results Among the 1,042 eyes of 615 patients, eight eyes (0.77%) of seven patients had DSM. Six of these eight eyes were not highly myopic (i.e., less than −6.0 diopters of spherical equivalents). Additionally, the mean height and diameter of the identified domes were 146.50 ± 42.33 μm and 4779.75 ± 699.38 μm, respectively. Patients with DSM were significantly older (mean age: 15.88 ± 2.36 years) than patients without it (11.51 ± 4.60 years; p = 0.007). The youngest affected patient was 11 years old. There was no significant difference in refractive errors (p = 0.629) or BCVA (p = 0.314) between the two groups. Conclusions Although the incidence in this study was very low, DSM was found even in children and adolescents. In addition, 75% of affected individuals were not highly myopic. These results suggest that inherent traits may be involved in development of DSM.

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Section: Discussioncontrasting

confidence: 94%

Section: Discussionmentioning

confidence: 57%

“…More recently, Xu et al reported DSM in young subjects with high myopia [13]. In their study, 17 eyes exhibited macular elevation.…”

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dome-shaped macula in children and adolescents

Shin

Park

2020

PLoS ONE

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Polarization-Sensitive OCT Imaging of Scleral Abnormalities in Eyes With High Myopia and Dome-Shaped Macula

Ohno-Matsui,

Igarashi-Yokoi,

Azuma

et al. 2024

JAMA Ophthalmol

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ImportanceThe relevance of visualizing scleral fiber orientation may offer insights into the pathogenesis of pathologic myopia, including dome-shaped maculopathy (DSM).ObjectiveTo investigate the orientation and density of scleral collagen fibers in highly myopic eyes with and without DSM by polarization-sensitive optical coherence tomography (PS-OCT).Design, Setting, and ParticipantsThis case series included patients with highly myopic eyes (defined as a refractive error ≥6 diopters or an axial length ≥26.5 mm) with and without a DSM examined at a single site in May and June 2019. Analysis was performed from September 2019 to October 2023.ExposuresThe PS-OCT was used to study the birefringence and optic axis of the scleral collagen fibers.Main Outcomes and MeasuresThe orientation and optic axis of scleral fibers in inner and outer layers of highly myopic eyes were assessed, and the results were compared between eyes with and without a DSM.ResultsA total of 72 patients (51 [70.8%] female; mean [SD] age, 61.5 [12.8] years) were included, and 89 highly myopic eyes were examined (mean [SD] axial length, 30.4 [1.7] mm); 52 (58.4%) did not have a DSM and 37 (41.6%) had a DSM (10 bidirectional [27.0%] and 27 horizontal [73.0%]). Among the 52 eyes without DSM, the 13 eyes with simple high myopia had primarily inner sclera visible, displaying radially oriented fibers in optic axis images. In contrast, the entire thickness of the sclera was visible in 39 eyes with pathologic myopia. In these eyes, the optic axis images showed vertically oriented fibers within the outer sclera. Eyes presenting with both horizontal and bidirectional DSMs had clusters of fibers with low birefringence at the site of the DSM. In the optic axis images, horizontally or obliquely oriented scleral fibers were aggregated in the inner layer at the DSM. The vertical fibers located posterior to the inner fiber aggregation were not thickened and appeared thin compared with the surrounding areas.Conclusions and RelevanceThis study using PS-OCT revealed inner scleral fiber aggregation without outer scleral thickening at the site of the DSM in highly myopic eyes. Given the common occurrence of scleral pathologies, such as DSM, and staphylomas in eyes with pathologic myopia, recognizing these fiber patterns could be important. These insights may be relevant to developing targeted therapies to address scleral abnormalities early and, thus, mitigate potential damage to the overlying neural tissue.

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Myopic Maculopathy

Fang

Ohno‐Matsui

2021

Pathologic Myopia

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Ridge-Shaped Macula in Young Myopic Patients and Its Differentiation From Typical Dome-Shaped Macula in Elderly Myopic Patients

Cited by 31 publications

References 27 publications

Dome-shaped macula in children and adolescents

Dome-shaped macula in children and adolescents

Polarization-Sensitive OCT Imaging of Scleral Abnormalities in Eyes With High Myopia and Dome-Shaped Macula

Myopic Maculopathy

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