Riesgo de fractura en la cohorte FRODOS: estudio comparativo de la aplicación del modelo FRAX® español, francés, inglés y sueco

Abstract

SummaryBackground and objectives: Studies on the validation of FRAX ® in Spain show an underestimation of the risk of principal osteoporotic fractures (POFs) and more accurate predictions for femoral fractures (FF). It has been suggested that this algorithm may be improved with more specific data on the epidemiology of these fractures in Spain. The objectives of this work were to describe the baseline risk of fractures according to the Spanish FRAX ® model in the participants of the FRODOS cohort, and to compare these data with the application of other European models of FRAX ® in the same cohort. Methods: Observational study in a population cohort of 2,968 postmenopausal women (59-70 years of age). The online desktop version of FRAX ® was used for multiple data entries to calculate the risk of POFs and FFs at 10 years using the Spanish, French, British and Swedish models in the same cohort. Results: The lowest risk corresponded to the Spanish model: FF: 1.22% (36 expected fractures) and POF: 5.28% (n=197), while the highest risk was for the Swedish model: FF: 3.15% and POF 13.51% (n=401). The models for France and the United Kingdom had intermediate values. Conclusion:In a Spanish cohort of 2,968 postmenopausal women the percentage risk of expected fractures at 10 years increased following a south-north latitude gradient when different European FRAX

Riesgo de fractura osteoporótica mayor y de cadera en pacientes con accidente cerebrovascular en fase aguda: estudio prospectivo multicéntrico

“…A cut off point of 10 was established for major osteoporotic fracture, and 3 for establishment of a high risk of hip fracture, due to these being the minimum cut off values which, when the study started, were recommended and used by other Spanish authors 20,21 . While there is increasing evidence that the FRAX ® index underestimates the risk of fractures in the Spanish population, major osteoporotic fractures in particular, although the prediction of hip fracture is more sensitive 22 , we should emphasise that this is the index most relevant to our study.…”