2023
DOI: 10.1101/2023.07.18.549543
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RIF1 integrates DNA repair and transcriptional requirements during the establishment of humoral immune responses

Abstract: RIF1 is a multifunctional protein that promotes immunoglobulin (Ig) isotype diversification. Whether RIF1 plays additional roles in adaptive immunity is unknown. In this study, we showed that Rif1 expression is upregulated following mature B cell activation, while its deficiency skewed the transcriptional profile of activated B cells towards plasmablasts (PBs) and plasma cells (PCs). Additionally, RIF1 ablation resulted in increased PB formation ex vivo and enhanced terminal differentiation into PCs upon immun… Show more

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