Rifabutin-induced uveitis with inflammatory vitreous infiltrate

Khan, Mushtaq A; Singh, Jaswinder; Dhillon, Baljean

doi:10.1038/eye.2000.85

Cited by 14 publications

(7 citation statements)

References 6 publications

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“…3 This type of uveitis occurs more rarely in immunocompetent patients. 5,6 It is clinically characterized by anterior uveitis, often accompanied by hypopyon and vitritis. Rifabutin-related vasculitis appears to be very rare.…”

Section: Discussionmentioning

confidence: 99%

“…2 Rifabutin-associated anterior uveitis has frequently been described in AIDS patients treated with a daily dose of 300-1800 mg. 3,4 Some cases have also been described in immunocompetent patients. 5,6 Concurrent therapy with clarithromycin or fluconazole increases the risk of iridocyclitis development. By inhibiting the hepatic microsomal cytochrome P-450 system, these drugs can elevate the serum rifabutin levels and precipitate the induction of intraocular inflammation.…”

Section: Introductionmentioning

confidence: 99%

“…A few cases of panuveitis have been reported, including one case occurring as a third recurrence on an extremely high dose of ribafutin and one case of rifabutin-associated retinal vasculitis. [3][4][5]8 In the latter case, the patient had also received an intravitreous injection of vancomycin and gentamicin for presumed endogenous endophthalmitis.…”

Section: Introductionmentioning

confidence: 99%

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Rifabutin-Associated Panuveitis with Retinal Vasculitis in Pulmonary Tuberculosis

Skolik

Willermain

Caspers

2005

Ocular Immunology and Inflammation

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Rifabutin-Associated Panuveitis with Retinal Vasculitis in Pulmonary Tuberculosis

Skolik

Willermain

Caspers

2005

Ocular Immunology and Inflammation

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“…In patients on anti-tuberculous therapy, regular hepatic, renal, and hematologic parameter monitoring should be conducted. This treatment is known to cause ocular adverse effects such as uveitis, 22 corneal endothelial deposits, 23 optic neuritis, 24 and optic atrophy and fundus changes such as slight vascular tortousity, peripheral snowball opacities, 25 cystoid macular edema, 25 or sclerosis of retinal vessels. Hence, regular ophthalmic examination for all of these adverse effects is warranted.…”

Section: Discussionmentioning

confidence: 99%

Appearance of Retinal Hemorrhages in Patients on Daily-Dose Anti-Tubercular Therapy

Sodhi

Sachdev²,

Verma

et al. 2004

Journal of Pharmacy Technology

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WWW.JPHARMTECHNOL.COMCombined antimicrobial chemotherapy has been shown to be very effective in the treatment of Mycobacterium tuberculosis hominis infections, although it can cause various toxic manifestations. 1 Anti-tuberculous drugs can cause these adverse effects by impairment of Mitochondrial function involved in oxidative phosphorylation, 2 production of antibodies and immune complexes, 3 or some underlying toxic, idiosyncratic, and/or hypersensitivity mechanism. 4 The systemic toxic manifestations are mostly due to rifampin 5,6 and, out of these, hepatotoxicity is the most common. 7,8 Allergic and other autoimmune manifestations, including thrombocytopenia, are rare and, notably, these are seen in association with an intermittent anti-tubercular regimen. 8, 9 We report 2 patients on daily-dose anti-tubercular therapy who presented with a single episode of retinal hemorrhage. The probable cause for such a presentation in these 2 patients is discussed. Case Reports CASE 1A 14-year-old female was diagnosed as having pulmonary tuberculosis. Her history was negative for other systemic illnesses (eg, diabetes, hypertension, blood disorders), ocular disease (eg, high myopia or trauma), and history of travel to high altitudes or Valsalva maneuver. Ocular examination showed that she had negative per-

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“…Uveitis is a rare adverse effect that is thought to be more associated with rifabutin than with other rifamycins [ 64 ]. However, most cases of uveitis have been described in patients on concurrent clarithromycin therapy, which is known to significantly increase rifabutin concentrations, while demonstrating minimal effect on rifampin concentrations [ 65 , 66 ]. Although the mechanism for this adverse effect has not been completely elucidated, clinicians should be aware of this potential complication in patients with acute vision changes.…”

Section: Pharmacologic Managementmentioning

confidence: 99%

Pharmacologic Management of Mycobacterium chimaera Infections: A Primer for Clinicians

Mason

Gregory

Foster

et al. 2022

Open Forum Infectious Diseases

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Mycobacterium chimaera, a member of the Mycobacterium avium complex, can cause infections in individuals after open-heart surgery due to contaminated heater-cooler units. The diagnosis can be challenging, as the incubation period can be quite variable, and symptoms are non-specific. In addition to aggressive surgical management, combination pharmacologic therapy is the cornerstone of therapy, which should consist of a macrolide, a rifamycin, ethambutol, and amikacin. Multiple second-line agents may be utilized in the setting of intolerances or toxicities. In vitro susceptibility of these agents is similar to activity against other species in the Mycobacterium avium complex. Drug-drug interactions are frequently encountered, as many individuals have chronic medical comorbidities and are prescribed medications that interact with first-line agents used to treat M. chimaera. Recognition of these drug-drug interactions and appropriate management are essential for optimizing treatment outcomes.

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Rifabutin-induced uveitis with inflammatory vitreous infiltrate

Cited by 14 publications

References 6 publications

Rifabutin-Associated Panuveitis with Retinal Vasculitis in Pulmonary Tuberculosis

Rifabutin-Associated Panuveitis with Retinal Vasculitis in Pulmonary Tuberculosis

Appearance of Retinal Hemorrhages in Patients on Daily-Dose Anti-Tubercular Therapy

Pharmacologic Management of Mycobacterium chimaera Infections: A Primer for Clinicians

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