Rifampicin allergy confirmed by an intradermal test, but with a negative patch test

Strauss, R.M.; Green, Steven T.; Gawkrodger, David J.

doi:10.1034/j.1600-0536.2001.045002108.x

Cited by 12 publications

(5 citation statements)

References 6 publications

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“…There are a lot of published cases of CADR with negative drug patch tests but positive delayed IDT [2,3] . This was also reported with rifampicin [119] .…”

Section: Negative Predictive Value Of Drug Patch Testssupporting

confidence: 72%

“…Prick tests and IDT have also been performed with other drugs such as local anesthetics (all negative in 236 patients, with only one localized reaction among 236 subcutaneous challenges [109,110] ), carboplatin (126 patients tested) [42] or platin salts [43] , clindamycin (2 delayed positive reactions/31 tested patients) [111] , corticosteroids [72,112] , dexchlorpheniramine (immediate positivity in 1 case) [113] , estradiol [3] , gadoterate meglumine [114] , heparin derivatives [38,[49][50][51][52] , insulin [115,116] , quinolones [95,117] , radiocontrast media [44,[46][47][48] , rifampicin (3 cases and 24 controls) [118,119] , and synergistins [40] with 3 positive results on 9 prick tests and 4/5 delayed positive results on IDT.…”

Section: Usefulness Of Drug Skin Tests According To the Tested Drugmentioning

confidence: 99%

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Place of Drug Skin Tests in Investigating Systemic Cutaneous Drug Reactions

Barbaud¹

2007

Drug Hypersensitivity

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Skin tests with drugs can be helpful in determining the cause of cutaneous adverse drug reactions (CADR). Patch tests and prick tests can be done with any commercialized form of a drug, intradermal tests (IDT) normally rely on the availability of a sterile solution used for parental applications. There has been some experience with different concentrations and techniques, but a complete standardization has not been done with these tests. Prick tests and IDT are used to investigate immediate hypersensitivity, patch tests and IDT with delayed readings are helpful for symptoms appearing delayed. They can be positive in different skin symptoms, with or without involvement of internal organs (e.g. hepatitis). A great variety of drugs can be tested, including antibiotics, antiepileptics, drugs used in oncology, drugs used for diagnosis etc. Except for IDT, skin tests with drugs rarely induce adverse reactions. False positive results can occur and should be considered, if a product for skin tests is evaluated for the first time. The negative predictive value of skin tests with drugs is a crucial point that will have to be studied in detail in the near future.

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“…There are a lot of published cases of CADR with negative drug patch tests but positive delayed IDT [2,3] . This was also reported with rifampicin [119] .…”

Section: Negative Predictive Value Of Drug Patch Testssupporting

confidence: 72%

Section: Usefulness Of Drug Skin Tests According To the Tested Drugmentioning

confidence: 99%

Place of Drug Skin Tests in Investigating Systemic Cutaneous Drug Reactions

Barbaud¹

2007

Drug Hypersensitivity

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“…In the test, rifampicin also showed positive reaction on day 2 but disappeared on day 4, then interpreted as an irritant reaction. However, the patch test result is not a confirmative one, and the rifampicin allergy with a negative patch test also has been reported previously (6). …”

Section: Discussionmentioning

confidence: 73%

Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Induced by Celecoxib and Anti-tuberculosis Drugs

et al. 2008

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Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome reflects a serious hypersensitivity reaction to drugs, characterized by skin rash, fever, lymph node enlargement, and internal organ involvement. So far, numerous drugs such as sulfonamides, phenobarbital, sulfasalazine, carbamazepine, and phenytoin have been reported to cause the DRESS syndrome. We report a case in a 29-yr-old female patient who had been on celecoxib and anti-tuberculosis drugs for one month to treat knee joint pain and pulmonary tuberculosis. Our patient's clinical manifestations included fever, lymphadenopathy, rash, hypereosinophilia, and visceral involvement (hepatitis and pneumonitis). During the corticosteroid administration for DRESS syndrome, swallowing difficulty with profound muscle weakness had developed. Our patient was diagnosed as DRESS syndrome with eosinophilic polymyositis by a histopathologic study. After complete resolution of all symptoms, patch tests were positive for both celecoxib and ethambutol. Although further investigations might be needed to confirm the causality, celecoxib and ethambutol can be added to the list of drugs as having the possibility of DRESS syndrome.

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“…There are a lot of published cases of CADR with negative drug patch tests but positive delayed IDT (Barbaud et al, 1998b(Barbaud et al, , 2000. It was also recently reported with rifampicin (Strauss et al, 2001).…”

Section: Predictive Negative Value Of Drug Patch Testsmentioning

confidence: 64%