Rifampicin in non-tuberculous infections.

Brumfitt, W.; Hamilton-Miller, J M

doi:10.1136/bmj.289.6443.496

Cited by 1 publication

(1 citation statement)

References 8 publications

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“…Rifampin has a 4 hr half-life and is relatively safe at doses under 1.2 g/day, under which adverse or side effect risk is small, although in rare cases serious [ 261 ]. Drug-induced hepatitis is recognized as a rare possibility.…”

Section: Safetymentioning

confidence: 99%

Blocking epithelial-to-mesenchymal transition in glioblastoma with a sextet of repurposed drugs: the EIS regimen

Kast¹,

Skuli

Karpel‐Massler

et al. 2017

Oncotarget

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This paper outlines a treatment protocol to run alongside of standard current treatment of glioblastoma- resection, temozolomide and radiation. The epithelial to mesenchymal transition (EMT) inhibiting sextet, EIS Regimen, uses the ancillary attributes of six older medicines to impede EMT during glioblastoma. EMT is an actively motile, therapy-resisting, low proliferation, transient state that is an integral feature of cancers’ lethality generally and of glioblastoma specifically. It is believed to be during the EMT state that glioblastoma’s centrifugal migration occurs. EMT is also a feature of untreated glioblastoma but is enhanced by chemotherapy, by radiation and by surgical trauma. EIS Regimen uses the antifungal drug itraconazole to block Hedgehog signaling, the antidiabetes drug metformin to block AMP kinase (AMPK), the analgesic drug naproxen to block Rac1, the anti-fibrosis drug pirfenidone to block transforming growth factor-beta (TGF-beta), the psychiatric drug quetiapine to block receptor activator NFkB ligand (RANKL) and the antibiotic rifampin to block Wnt- all by their previously established ancillary attributes. All these systems have been identified as triggers of EMT and worthy targets to inhibit. The EIS Regimen drugs have a good safety profile when used individually. They are not expected to have any new side effects when combined. Further studies of the EIS Regimen are needed.

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Section: Safetymentioning

confidence: 99%