Rifampicin-loaded PLGA nanoparticles for local treatment of musculoskeletal infections: Formulation and characterization

Snejdrova, Eva; Loskot, Jan; Martiska, Juraj; Soukup, Tomáš; Prokes, Libor; Frolov, Vladislav; Kucera, Tomas

doi:10.1016/j.jddst.2022.103435

Cited by 17 publications

(16 citation statements)

References 58 publications

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“…The above-mentioned results were in accordance with previous studies [ 27 , 29 , 30 ]. Sakhi and co-authors developed polymeric nanoparticles loaded with paclitaxel for treatment of breast cancer.…”

Section: Resultssupporting

confidence: 93%

Development of favipiravir loaded PLGA nanoparticles entrapped in in-situ gel for treatment of Covid-19 via nasal route

Gattani

Dawre

2023

Journal of Drug Delivery Science and Technology

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Section: Resultssupporting

confidence: 93%

Development of favipiravir loaded PLGA nanoparticles entrapped in in-situ gel for treatment of Covid-19 via nasal route

Gattani

Dawre

2023

Journal of Drug Delivery Science and Technology

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“…There was also a small shift in the glass transition of the solid dispersion at 24.3 °C due to the incorporation of the drugs. Such a behavior occurred, because the drugs were molecularly dispersed in the PLGA carrier and acted as plasticizers [ 30 , 31 ].…”

Section: Resultsmentioning

confidence: 99%

Allogeneic Bone Impregnated with Biodegradable Depot Delivery Systems for the Local Treatment of Joint Replacement Infections: An In Vitro Study

et al. 2022

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Although progress is evident in the effective treatment of joint replacement-related infections, it still remains a serious issue in orthopedics. As an example, the local application of antibiotics-impregnated bone grafts supplies the high drug levels without systemic side effects. However, antibiotics in the powder or solution form could be a risk for local toxicity and do not allow sustained drug release. The present study evaluated the use of an antibiotic gel, a water-in-oil emulsion, and a PLGA microparticulate solid dispersion as depot delivery systems impregnating bone grafts for the treatment of joint replacement-related infections. The results of rheological and bioadhesive tests revealed the suitability of these formulations for the impregnation of bone grafts. Moreover, no negative effect on proliferation and viability of bone marrow mesenchymal stem cells was detected. An ex vivo dissolution test of vancomycin hydrochloride and gentamicin sulphate from the impregnated bone grafts showed a reduced burst and prolonged drug release. The PLGA-based formulation proved to be particularly promising, as one-day burst release drugs was only 15% followed with sustained antibiotics release with zero-order kinetics. The results of this study will be the basis for the development of a new product in the Tissue Section of the University Hospital for the treatment of bone defects and infections of joint replacements.

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“…Among the strategies reported in the literature to overcome these difficulties and improve the therapeutic efficacy of anti-TB drugs is to devise modified drug delivery systems (MDDS). Several works in the literature have reported obtaining MDDS for RIF, using the most diverse types of carriers, such as polymeric nanoparticles [ 10 , 11 , 12 ], microemulsions [ 13 ], dendrimers [ 14 , 15 ], hydrogels [ 6 , 16 , 17 ], liposomes [ 18 ], and lipid nanoparticles [ 19 ], among others. Despite being effective, such systems are based on expensive technologies that require the use of improved materials and/or devices.…”

Section: Introductionmentioning

confidence: 99%

Montmorillonite–Rifampicin Nanohybrid for pH-Responsive Release of the Tuberculostatic

et al. 2023

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The present work describes the development of a hybrid and pH-responsive system for rifampicin using the clay mineral ‘montmorillonite’ as a nanocarrier. The influence of operational variables on the drug incorporation process was evaluated using 24 factorial designs. Under optimized conditions, the experiment allowed an incorporated drug dose equivalent to 98.60 ± 1.21 mg/g. Hybrid systems were characterized by different characterization techniques (FTIR, XRD, TGA, DSC, and SEM) to elucidate the mechanism of interaction between the compounds used. Through in vitro release studies, it was possible to verify the efficacy of the pH-dependent system obtained, with approximately 70% of the drug released after sixteen hours in simulated intestinal fluid. The adjustment of the experimental release data to the theoretical model of Higuchi and Korsmeyer–Peppas indicated that the release of rifampicin occurs in a prolonged form from montmorillonite. Elucidation of the interactions between the drug and this raw clay reinforces its viability as a novel carrier to develop an anti-TB/clay hybrid system with good physical and chemical stability.

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Rifampicin-loaded PLGA nanoparticles for local treatment of musculoskeletal infections: Formulation and characterization

Cited by 17 publications

References 58 publications

Development of favipiravir loaded PLGA nanoparticles entrapped in in-situ gel for treatment of Covid-19 via nasal route

Development of favipiravir loaded PLGA nanoparticles entrapped in in-situ gel for treatment of Covid-19 via nasal route

Allogeneic Bone Impregnated with Biodegradable Depot Delivery Systems for the Local Treatment of Joint Replacement Infections: An In Vitro Study

Montmorillonite–Rifampicin Nanohybrid for pH-Responsive Release of the Tuberculostatic

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