Rifampin, a Useful Drug for Nonmycobacterial Infections

Vesely, Josef J. K.; Pien, Francis D.; Pien, Brian C. T.

doi:10.1002/j.1875-9114.1998.tb03861.x

Cited by 34 publications

(2 citation statements)

References 149 publications

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“… 30 It also has clinical efficacy against Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Neisseria , and some other bacteria. 31 According to CLSI M100, 32th edition, Enterobacteriaceae are intrinsically resistant to rifampicin. 18 However, Mumbo et al reported that rifampicin resistance was observed in 11.1% of Salmonella isolates, and clinical efficacy was also observed in Salmonella Typhi and E. coli .…”

Section: Discussionmentioning

confidence: 99%

“…18 However, Mumbo et al reported that rifampicin resistance was observed in 11.1% of Salmonella isolates, and clinical efficacy was also observed in Salmonella Typhi and E. coli . 31 , 32 Furthermore, Salmonella was previously used as a model organism to investigate rifampicin resistance. 33–35 The wild-type Salmonella enterica exhibited MIC against rifampicin was 12 mg/L, whereas its rifampicin-resistant mutants showed high rifampicin resistance with MICs of 1500 to >3000 mg/L.…”

Section: Discussionmentioning

confidence: 99%

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Persistent Colonization of Ciprofloxacin-Resistant and Extended-Spectrum β-Lactamase (ESBL)-Producing Salmonella enterica Serovar Kentucky ST198 in a Patient with Inflammatory Bowel Disease

Jiang,

Yang,

Wang

et al. 2024

IDR

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Salmonella enterica serovar Kentucky ST198 has emerged as a global threat to humans. In this study, we aimed to characterize the prolonged carriage of ciprofloxacin-resistant and extended-spectrum β-lactamase (ESBL)-producing S. Kentucky ST198 in a single patient with inflammatory bowel disease (IBD). Methods: Three S. Kentucky strains were collected from a single patient with IBD on 11th January, 23rd January, and 8th February, 2022, respectively. Antimicrobial susceptibility testing, whole-genome sequencing, and phylogenetic analysis with 38 previously described Chinese S. Kentucky ST198 strains from patients and food were performed. Results: All three S. Kentucky isolates belonged to ST198. They carried identical 16 resistance genes, such as bla CTX-M-55 , tet(A), and qnrS1, and had identical mutations within gyrA (S83F and D87N) and parC (S80I). Therefore, they exhibited identical multidrugresistant profiles, including the clinically important antibiotics cephalosporins (ceftazidime and cefepime), fluoroquinolones (ciprofloxacin and levofloxacin), and third-generation tetracycline (tigecycline). Our three S. Kentucky strains were classified into the subclade ST198.2-2, and were genetically identical (2-6 SNPs) to each other. They exhibited a close genetic similarity (15-20 SNPs) to the isolate NT-h3189 from a patient and AH19MCS1 from chicken meat in China, indicating a possible epidemiological link between these S. Kentucky ST198 isolates from the patients and chicken meat. Conclusion: Long-term colonization of ciprofloxacin-resistant and ESBL-producing S. Kentucky ST198 in a single patient is a matter of concern. Due to the potential transfer of S. Kentucky ST198 from food sources to humans, ongoing surveillance of this particular clone in animals, animal-derived food products, and humans should be strengthened.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Persistent Colonization of Ciprofloxacin-Resistant and Extended-Spectrum β-Lactamase (ESBL)-Producing Salmonella enterica Serovar Kentucky ST198 in a Patient with Inflammatory Bowel Disease

Jiang,

Yang,

Wang

et al. 2024

IDR

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Staphylococcus epidermidis is cleared from biomaterial implants but persists in peri‐implant tissue in mice despite rifampicin/vancomycin treatment

Broekhuizen

Boer

Schipper

et al. 2007

J Biomedical Materials Res

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Infections associated with implanted biomedical devices (BAI) are predominantly caused by Staphylococcus epidermidis. We previously observed in murine experimental BAI that S. epidermidis persists in peri-implant tissue rather than on the implanted biomaterial itself (Boelens et al., J Infect Dis 2000;181:1337-1349; Broekhuizen et al., Infect Immun 2007;75:1129-1136). To investigate the efficacy of rifampicin/vancomycin to clear S. epidermidis from implants and peri-implant tissues, mice with two implants were challenged with 10(7) cfu S. epidermidis per implant and received daily injections of rifampicin (25 mg/kg) and vancomycin (50 mg/kg). On the day of termination, implants and peri-implant tissue were collected and processed for culture and histology. After 1 and 8 days, implants of control mice were culture positive in 14/18 and 5/16 cases, respectively, and tissue biopsies were all culture positive. In the antibiotic-treated mice, bacteria were recovered from only 1/18 and 1/16 implants after 1 and 8 days, respectively, whereas the tissues were culture positive in 14/18 and 7/16 biopsies, respectively. In microscopy, bacteria were seen in the tissue at a distance of several cell layers from the tissue-implant interface, colocalized with host cells. Thus, although a regimen of rifampicin/vancomycin sterilized the implants, S. epidermidis persisted in peri-implant tissue, which might be an as yet unrecognized reservoir in the pathogenesis of BAI.

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CNS Infections

Nadel

Cooper

2014

Pediatric Critical Care Medicine

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Rifampin, a Useful Drug for Nonmycobacterial Infections

Cited by 34 publications

References 149 publications

Persistent Colonization of Ciprofloxacin-Resistant and Extended-Spectrum β-Lactamase (ESBL)-Producing Salmonella enterica Serovar Kentucky ST198 in a Patient with Inflammatory Bowel Disease

Persistent Colonization of Ciprofloxacin-Resistant and Extended-Spectrum β-Lactamase (ESBL)-Producing Salmonella enterica Serovar Kentucky ST198 in a Patient with Inflammatory Bowel Disease

Staphylococcus epidermidis is cleared from biomaterial implants but persists in peri‐implant tissue in mice despite rifampicin/vancomycin treatment

CNS Infections

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