Rifamycin SV Application to Subcutanous Tissue for Prevention of Post-Cesarean
Surgical Site Infection

Köşüş, Aydın; Köşüş, Nermin; Güler, Ayşe; Çapar, Metin

doi:10.29333/ejgm/82867

Cited by 15 publications

(17 citation statements)

References 33 publications

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“…Setting & procedure. The setting where the findings are derived from were mainly public teaching hospitals [41, 52, 57-62, 64, 66] with three based in private hospitals [53][54][55]63]. All the studies were based in single centres.…”

Section: Plos Onementioning

confidence: 99%

Surgical site infection and costs in low- and middle-income countries: A systematic review of the economic burden

et al. 2020

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Background Surgical site infection (SSI) is a worldwide problem which has morbidity, mortality and financial consequences. The incidence rate of SSI is high in Low-and Middle-Income countries (LMICs) compared to high income countries, and the costly surgical complication can raise the potential risk of financial catastrophe. Objective The aim of the study is to critically appraise studies on the cost of SSI in a range of LMIC studies and compare these estimates with a reference standard of high income European studies who have explored similar SSI costs. Methods A systematic review was undertaken using searches of two electronic databases, EMBASE and MEDLINE In-Process & Other Non-Indexed Citations, up to February 2019. Study characteristics, comparator group, methods and results were extracted by using a standard template. Results Studies from 15 LMIC and 16 European countries were identified and reviewed in full. The additional cost of SSI range

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Section: Plos Onementioning

confidence: 99%

Surgical site infection and costs in low- and middle-income countries: A systematic review of the economic burden

et al. 2020

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“…[25] The first local application of rifamycin SV, the target agent of this study, was conducted in lung caverns; several subsequent studies have shown its topical use on both animals and wounds that occurred due to human surgery and trauma. [26][27][28][29] In their study, Kaya et al [27] reported that in the tibia defect they created in rats, rifamycin caused significant histological improvement and new bone formation in the group where a bone graft was not used compared to the control group. Iselin et al [28] reported that topical rifamycin is useful for hand injuries, and could control infection and accelerate wound recovery.…”

Section: Discussionmentioning

confidence: 99%

“…In the rifamycin group, the symptoms of infection significantly decreased and the recovery was faster. In a clinical study conducted by Köşüş et al, [29] 1,196 patients who had cesarean incisions were divided into two groups; povidone iodine was applied to patients in the first group preoperatively and postoperatively at the site of incision, while in the second group, the patients were applied rifamycin SV to subcutaneous tissue before closure of skin, in addition to application of povidone iodine. Overall, rifamycin SV applied under the skin decreased infection at the site and the cost of treatment.…”

Section: Discussionmentioning

confidence: 99%

Ototoxic effect of topical rifamycin SV applied in the middle ear of rats

Özbay¹,

Şahin²

2017

Kulak Burun Bogaz Ihtis Derg

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Objectives:In this study, we aimed to evaluate the ototoxic effect of topical rifamycin SV in the middle ear in a rat model. Materials and Methods:A total of 24 20-week-old adult female and eight 4-6-week-old weaned (young, post-suckling period) Wistar albino rats were used. Adult rats were separated into four groups: Group 1 (adult rifamycin), group 2 (weaner rifamycin), group 3 (gentamicin; positive control), and group 4 (saline; negative control). Before medication administration, an auditory brainstem response (ABR) test was performed on each animal under general anesthesia. Tympanic membranes of the animals were perforated, and the medications were administered to the middle ear for 10 days. Three weeks after treatment, ABR tests were repeated and pre-and posttreatment ABR threshold measurements were compared. Results:Although the mean pre-and post-treatment ABR threshold values did not significantly differ among groups 1, 2, and 4 (p>0.05), the mean post-treatment ABR threshold values were significantly higher in group 3 compared to baseline (p<0.05). Conclusion:Based on ABR measurements, the topical use of rifamycin SV, a broad-spectrum semi-synthetic antibiotic in the middle ear, does not cause hearing loss in adult or weaner rats.Keywords: Auditory brainstem response; inner ear; ototoxicity; rifamycin SV. ÖZAmaç: Bu çalışmada bir sıçan modelinde topikal rifamisin SV'nin orta kulakta ototoksik etkisi araştırıldı. Gereç ve Yöntemler:Toplamda 24 adet, 20 haftalık erişkin dişi ve sekiz adet 4-6 haftalık (sütten kesilmiş yavru) Wistar albino sıçan kullanıldı. Erişkin sıçanlar dört gruba ayrıldı; Grup 1 (erişkin rifamisin), grup 2 (yavru rifamisin), grup 3 (gentamisin; pozitif kontrol), grup 4 (salin, negatif kontrol). İlaç uygulaması öncesinde her sıçana genel anestezi altında işitsel beyinsapı yanıtı (ABR) testi uygulandı. Hayvanların timpan membranları perfore edilerek, orta kulağa 10 gün boyunca ilaçlar uygulandı. Tedaviden üç hafta sonra ABR testleri tekrar edildi ve tedavi öncesi ve sonrası ABR eşik ölçümleri karşılaştırıldı. Bulgular:Tedavi öncesi ve tedavi sonrası ortalama ABR eşik değerleri grup 1, grup 2 ve grup 4'te istatistiksel olarak anlamlı farklılık göstermez iken (p>0.05), grup 3'te tedavi sonrası ortalama ABR eşik değerleri, başlangıca kıyasla, anlamlı düzeyde daha yüksekti (p<0.05).Sonuç: İşitsel beyinsapı yanıtı ölçümlerine dayanarak, geniş spektrumlu yarı sentetik bir antibiyotik olan rifamisin SV'nin orta kulakta topikal kullanımı, erişkin veya yavru sıçanlarda işitme kaybına neden olmamaktadır.Anahtar Sözcükler: İşitsel beyinsapı yanıtı; iç kulak; ototoksisite; rifamisin SV.

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“…Rare allergic reactions and a few adverse effects may occur after local application of rifamycin. 14,15 Rifamycins are used for surgical site infection in orthopedic and maxillofacial surgeries and are well tolerated by bone tissue. Previous studies reported rifamycin may positively affect bone tissue, extraction socket healing, and osteomyelitis treatment.…”

mentioning

confidence: 99%

Effect of Local Rifamycin Application on Expression of BMP-2 and Bone Regeneration

Ün¹,

Özeç²,

Taşdemir³

et al. 2017

Cumhuriyet Dental Journal

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Objectives: The aim of this study was to evaluate effect of local rifamycin application on BMP-2 expression and bone healing.Materials and Methods: A standardized 5.0-mm-diameter critical size bone defect was created mandible angulus region. In the control group (8 rats) defects were left empty. In the Group 1 (n=8 rats) defect was irrigated with rifamycin solution and 25 mg rifamycin solution injected defect area at 1, 3, 7 days after surgery. In the group 2 (n=8 rats) defects were grafted with a gelatin sponge mixed 25 mg rifamycin solution. Rats were sacrificed at 21 days after surgery. Histological slides were prepared from defect site for both immunohistochemical analysis (bone morphogenetic protein-2 (BMP-2) antibody) and histomorphometric analysis. Data were analyzed using Mann Whitney U and Kruskall Wallis test.

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Rifamycin SV Application to Subcutanous Tissue for Prevention of Post-Cesarean Surgical Site Infection

Abstract: Aim

Cited by 15 publications

References 33 publications

Surgical site infection and costs in low- and middle-income countries: A systematic review of the economic burden

Surgical site infection and costs in low- and middle-income countries: A systematic review of the economic burden

Ototoxic effect of topical rifamycin SV applied in the middle ear of rats

Effect of Local Rifamycin Application on Expression of BMP-2 and Bone Regeneration

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