2015
DOI: 10.4238/2015.october.28.42
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RIG-I detects HIV-1 infection and mediates type I interferon response in human macrophages from patients with HIV-1-associated neurocognitive disorders

Abstract: The aim of this study was to explore the precise role of retinoic acid-inducible gene-I (RIG-I) signaling in human immunodeficiency virus type 1 (HIV-1)-infected macrophages from patients with HIV-1-associated neurocognitive disorders (HAND). Postmortem brain tissues were collected from patients with HIV-1-associated dementia and were compared to samples collected from HIV serum-positive patients without dementia and HIV serum-negative patients. A human monocyte-derived macrophage (MDM) primary culture system … Show more

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Cited by 18 publications
(16 citation statements)
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“…Specific BEN + pattern changes in 4 pathways enriched in Hub genes are identified in SIV-infected SMs. These include the pathways contributing to interferon signaling, BRCA1/DNA damage response, PKR/INF induction and LGALS8 [ 35 , 44 46 ]. These genes were significantly upregulated at two or three time points of SIV infection.…”
Section: Resultsmentioning
confidence: 99%
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“…Specific BEN + pattern changes in 4 pathways enriched in Hub genes are identified in SIV-infected SMs. These include the pathways contributing to interferon signaling, BRCA1/DNA damage response, PKR/INF induction and LGALS8 [ 35 , 44 46 ]. These genes were significantly upregulated at two or three time points of SIV infection.…”
Section: Resultsmentioning
confidence: 99%
“…These genes were significantly upregulated at two or three time points of SIV infection. There are three enriched pathways (PRR-activated IRF signaling, RIG1-like receptor and PRR pathway) contributing to the mixed (BEN + /MAL + ) phenotypes of SIV infections in RMs and SMs, suggesting that these pathways play a dual role in the host defense against viral infections [ 44 , 47 48 ].…”
Section: Resultsmentioning
confidence: 99%
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“…These nucleic acids, as well as HIV-1 transcripts that are generated from proviruses, potentially act as PAMPs [23,24,[32][33][34][35][36][37]. Both RLR family members, including retinoic acid inducible gene I (RIG-I) and melanoma-differentiation-associated protein 5 (MDA5), and TLR family members (TLR7 and TLR8) have been characterized as PRRs of HIV-1 RNAs [27,35]. TLR7 was the first reported PRR that detects HIV-1 ssRNA present in the endocytic compartment in plasmacytoid dendric cells (pDCs) as a result of abortive infection due to endocytosis of HIV-1 [33,38].…”
Section: Hiv-1 Rna Sensorsmentioning
confidence: 99%
“…Viral RNA detector [216][217][218][219][220] Upregulated in the hippocampus [29] S100A4 S100 calcium binding protein A4…”
Section: Cc-by-nc-ndmentioning
confidence: 99%