Abstract.A 5-month-old male Thoroughbred foal with a history of chronic septic arthritis of the tibiotarsal joint and recent respiratory distress was euthanized and a postmortem examination performed. A giant diverticulum communicating with the lateral aspect of the right atrial cavity of the heart was observed. Histologically, the wall was comprised of myocardial tissue containing cavernous vascular spaces. There was gross and histologic evidence of right-sided heart failure. Congenital right atrial diverticula are rare anomalies in humans and have not previously been reported in foals.Cardiac diverticula are congenital or occasionally acquired fibrous or muscular outpouchings from atrial or ventricular cavities. 3,4 They are rarely reported in humans, and most commonly occur through a defect in the left ventricular myocardium. 8 A few cases of right and left atrial diverticula have been documented in children and adults 1,2,4-7 ; this is the first report of a right atrial diverticulum in a foal.A 5-month-old male Thoroughbred foal was presented to the referring veterinarian with septic arthritis of the right tibiotarsal joint, which had been treated for several months. The foal became recumbent, with increased respiratory and heart rates and increased respiratory sounds. The foal was euthanized and presented to the Livestock Disease Diagnostic Center, Lexington, Kentucky, for postmortem examination.At necropsy, the pericardial sac was opaque and expanded by a 20-ϫ 25-ϫ 25-cm hollow mass, which was slightly larger than the entire heart. The mass had a 2-5-mm-thick muscular wall, which was continuous with the lateral wall of the right atrium (Fig. 1). The central lumen communicated with the right atrial cavity via a 10-cm diameter opening and contained clotted blood, which was not adherent to the inner lining. A right atrial appendage was not noted, and the coronary groove on the right side was deviated ventrally (Fig. 1). Right and left ventricular walls measured 1.2 cm and 3.2 cm in thickness, respectively. The right ventricle formed the apex of the heart, and the right ventricular cavity and right atrioventricular orifice were dilated. Caudal regions of right and left lung lobes were red and firm. The liver was swollen, with an irregular surface and an enhanced lobular pattern. The right tibiotarsal joint was markedly distended by opaque, tan fluid, and the synovial lining was red and significantly thickened. Large irregular regions of ulceration of the articular cartilage were noted on the lateral and medial malleoli of the right tibia and lateral and medial trochlear ridges of the talus; exposed subchondral bone of the talus was brown and soft, with an irregular surface. Streptococcus zooepidemicus was isolated in pure culture from the lung, spleen, and right tibiotarsal joint.Representative tissue specimens were fixed in 10% neutral buffered formalin, processed routinely, and sectioned at 5