Right brain, left brain in depressive disorders: Clinical and theoretical implications of behavioral, electrophysiological and neuroimaging findings

Bruder, Gerard E.; Stewart, Jonathan W.; McGrath, Patrick J.

doi:10.1016/j.neubiorev.2017.04.021

Cited by 154 publications

(131 citation statements)

References 182 publications

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“…Finally, reliability and consistency of measuring FAA might be improved by EEG recording across multiple sessions, as FAA is found to be moderately stable across time (Allen et al, 2004, Vuga et al, 2006), as originally suggested by Davidson (1998). For a detailed and recent overview of studies on hemispheric asymmetry in depression, please see the review by Bruder et al (2017).…”

Section: Discussionmentioning

confidence: 91%

Frontal alpha asymmetry as a diagnostic marker in depression: Fact or fiction? A meta-analysis

Vinne

Vollebregt

Putten

et al. 2017

NeuroImage: Clinical

236

198

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BackgroundFrontal alpha asymmetry (FAA) has frequently been reported as potential discriminator between depressed and healthy individuals, although contradicting results have been published. The aim of the current study was to provide an up to date meta-analysis on the diagnostic value of FAA in major depressive disorder (MDD) and to further investigate discrepancies in a large cross-sectional dataset.MethodsSCOPUS database was searched through February 2017. Studies were included if the article reported on both MDD and controls, provided an FAA measure involving EEG electrodes F3/F4, and provided data regarding potential covariates. Hedges' d was calculated from FAA means and standard deviations (SDs). Potential covariates, such as age and gender, were explored. Post hoc analysis was performed to elucidate interindividual differences that could explain interstudy discrepancies.Results16 studies were included (MDD: n = 1883, controls: n = 2161). After resolving significant heterogeneity by excluding studies, a non-significant Grand Mean effect size (ES) was obtained (d = − 0.007;CI = [− 0.090]–[0.075]). Crosssectional analyses showed a significant three-way interaction for Gender × Age × Depression severity in the depressed group, which was prospectively replicated in an independent sample.ConclusionsThe main result was a non-significant, negligible ES, demonstrating limited diagnostic value of FAA in MDD. The high degree of heterogeneity across studies indicates covariate influence, as was confirmed by crosssectional analyses, suggesting future studies should address this Gender × Age × Depression severity interaction. Upcoming studies should focus more on prognostic and research domain usages of FAA rather than a pure diagnostic tool.

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Section: Discussionmentioning

confidence: 91%

Frontal alpha asymmetry as a diagnostic marker in depression: Fact or fiction? A meta-analysis

Vinne

Vollebregt

Putten

et al. 2017

NeuroImage: Clinical

236

198

View full text Add to dashboard Cite

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“…The right and left side of the brain are asymmetric in anatomy and function. A previous review electrophysiological (EEG and event-related potential), behavioral (dichotic and visual perceptual asymmetry), and neuroimaging (PET, MRI, NIRS) evidence of right-left asymmetry in depressive disorders (Bruder et al 2017). Our spatial dynamic study also found that after escitalopram treatment, sleep EEG responses in the left and right hemispheres were asymmetrical.…”

Section: Discussionmentioning

confidence: 99%

Spatio-temporal dynamics of EEG features during sleep in major depressive disorder after treatment with escitalopram: A pilot study

Wang

Yang³

et al. 2020

Preprint

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Background: Previous studies have shown escitalopram is related to sleep quality. However, effects of escitalopram on dynamics of electroencephalogram (EEG) features especially during different sleep stages have not been reported. This study may help to reveal pharmacological mechanism underlying escitalopram treatment. Methods:The spatial and temporal responses of patients with major depressive disorder (MDD) to escitalopram treatment were analyzed in this study. Eleven MDD patients and eleven healthy control subjects who completed eight weeks' treatment of escitalopram were included in the final statistics.Six-channel sleep EEG signals were acquired during sleep. Power spectrum and nonlinear dynamics were used to analyze the spatio-temporal dynamics features of the sleep EEG after escitalopram treatment.Results: For temporal dynamics: after treatment, there was a significant increase in the relative energy (RE) ofA band (0.5 -2Hz), accompanied by a significant decrease in the RE ofb band (20 -30Hz). Lempel-Ziv complexity and Co -complexity values were significantly lower. EEG changes at different sleep stages also showed the same regulation as throughout the night sleep. For spatio dynamics: after treatment, the EEG response of the left and right hemisphere showed asymmetry.Regarding band-specific EEG complexity estimations, δ1 and β2 in stage-1 and δ1 in stage-2 sleep stage in frontal cortex is found to be much more sensitive to escitalopram treatment in comparison to central and occipital cortices. Conclusions:The sleep quality of MDD patients improved, EEG response occurred asymmetry in left and right hemispheres due to escitalopram treatment, and frontal cortex is found to be much more sensitive to escitalopram treatment. These findings may contribute to a comprehensive understanding of the pharmacological mechanism of escitalopram in the treatment of depression.

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“…Moreover, the right-hemisphere hyperactivity in depression may be due to dysfunction in the inhibitory system (Pereira and Khan 2017) and reduced left frontal activity in major depressive disorder may be associated with decreased response of striatum to positive stimuli (Bruder et al 2017). However, brain lateralization of emotions may be more complex and region-specific than it is proposed.…”

Section: Discussionmentioning

confidence: 99%

Oculometric Behavior Assessed by Pupil Response is Altered in Adolescent Depression

et al. 2019

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Oculometric behaviour assessed by pupil response provides important information about central autonomic activity and emotional regulation. However, studies regarding pupil response to emotional stimuli in adolescent depression are rare. We aimed to study emotional-linked pupil response in adolescent depression. Twenty depressive adolescents (average age: 15.4±1.2 years) and 20 age/gender-matched healthy subjects were examined. Average pupil diameter assessed by eye-tracking and pupillary light reflex were evaluated during protocolbaseline, free-view task, recovery phase. Regarding right eye, significantly greater initial pupil diameter and pupil dilation to positive pictures free-viewing (p=0.013, p=0.031, respectively), significantly slower average and maximum constriction velocity in baseline and positive pictures free-viewing (p=0.036, p=0.050, p=0.021, p=0.015, respectively), significantly slower maximum constriction velocity in recovery phase (p=0.045), and significantly faster average dilation velocity in negative pictures free-viewing (p=0.042) were observed in depressive group. Regarding left eye, significantly lower constriction percentual change in negative pictures free-viewing (p=0.044) and significantly greater baseline pupil diameter and pupil diameter at the peak of constriction in positive vs. negative pictures freeviewing (p=0.002, p=0.015, respectively) were observed in depressive group. Our study revealed discrete central autonomic dysregulation -parasympathetic hypoactivity associated with relative sympathetic dominance influenced by impairments in emotional processing already in adolescent depression.

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Right brain, left brain in depressive disorders: Clinical and theoretical implications of behavioral, electrophysiological and neuroimaging findings

Cited by 154 publications

References 182 publications

Frontal alpha asymmetry as a diagnostic marker in depression: Fact or fiction? A meta-analysis

Frontal alpha asymmetry as a diagnostic marker in depression: Fact or fiction? A meta-analysis

Spatio-temporal dynamics of EEG features during sleep in major depressive disorder after treatment with escitalopram: A pilot study

Oculometric Behavior Assessed by Pupil Response is Altered in Adolescent Depression

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