“…This approach should be the best thing to do, but there are limitations that remain a major obstacle: the invasiveness of pulmonary artery catheter and transplumonary dilution technique and the poor accuracy and precision of the non-invasive devices (Vigileo - Edwards Lifesciences, Irvine, CA, USA; LiDCO - LiDCO Ltd, Cambridge, UK; ecc.) [28,29]. On the other hand, in moderate to high risk patient who is scheduled to undergo major surgery expected to last > 180 minute, a GTD approach with the optimization of hemodynamic parameters could reduce complications [8,30].…”