This patient was diagnosed with Patent Foramen Ovale (PFO) due to recurrent headaches, and her headaches improved significantly after oval foramen occlusion, but a grade 3/6 coarse murmur was heard in the aortic valve auscultation area, and left ventricular outflow tract stenosis was suggested by cardiac ultrasound. This change may be related to a variety of factors, suggesting that we should do a good preoperative assessment of the patient; intraoperative operation as gentle as possible to reduce the damage to the surrounding tissues; postoperative operation should be strengthened to avoid the progression of the inflammatory process, and at the same time to pay attention to the patient's symptoms, signs and dynamics of the relevant examinations to reduce the incidence of complications.