Right Hemihepatectomy for Colon Cancer Metachronous Liver Metastasis in a Patient with Crohn\'s Disease: Case Report and Review of the Literature

Negoi, Ionuț; Runcanu, Alexandru; Păun, Sorin; Beuran, Mircea

doi:10.21614/chirurgia.111.6.522

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…Colorectal cancer (CRC) was one of the most common malignancies arising from the digestive system, acting as a major reason for cancer-related death [1]. Despite the early diagnosis and treatment of CRC developed in recent years, the 5-year survival rate for colorectal cancer is still not satisfactory, mainly because most patients are diagnosed with distant metastasis or at an advanced stage [2]. Although some traditional methods, such as imaging and hematological examinations were already used in practice, they were limited by their low sensitivity and specificity.…”

Section: Introductionmentioning

confidence: 99%

A 3-circular RNA signature as a noninvasive biomarker for diagnosis of colorectal cancer

Wang

Huang

et al. 2019

Cancer Cell Int

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BackgroundCircular RNAs (circRNAs), a novel type of noncoding RNAs, play critical roles in the initiation and progression of cancer. Emerging studies also shows that circRNAs may function as potential markers for cancer diagnosis and treatment. However, the diagnostic value of circRNAs in colorectal cancer (CRC) remains need to be unearthed.MethodsCircRNA microarray was performed to detect the differentially expressed circRNAs in eight plasma samples, including four colorectal cancer (CRC) and four normal samples. Besides, the results of microarray were validated by quantitative real-time polymerase chain reaction (qRT-PCR). Moreover, ROC curve evaluation was performed to calculate the diagnostic value of significantly dysregulated circRNAs. In order to predict the potential mechanism of the significant circRNAs, circRNA–miRNA–mRNA network was constructed based on the TargetScan, miRTarBase and MIRDB database, as well as CircInteractome online software. Furthermore, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to further predict the function of meaningful circRNAs.ResultsTotally three differentially expressed circRNAs were identified in CRC plasma compared to normal plasma by circRNA microarray analysis, and the results was validated by qRT-PCR. Hsa_circ_0082182, hsa_circ_0000370 and hsa_circ_0035445 were identified and ROC curves analysis was used to calculate the single and joint diagnostic value. Furthermore, GO and KEGG analyses revealed that functions were mainly cancer-related, which indicated that the circRNAs were meaningfully associated with CRC cell proliferation and metastasis.ConclusionIn conclusion, we have identified three circRNAs that are dysregulated in CRC plasma, including hsa_circ_0082182, hsa_circ_0000370 and hsa_circ_0035445. ROC curves showed that these circRNAs might have diagnostic value for colorectal cancer. Furthermore, bioinformatics analysis indicated that the above-mentioned circRNAs might be involved in the development of CRC.

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Section: Introductionmentioning

confidence: 99%

A 3-circular RNA signature as a noninvasive biomarker for diagnosis of colorectal cancer

Wang

Huang

et al. 2019

Cancer Cell Int

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“…Colorectal cancer (CRC) was one common malignancy arising from the human digestive tract, serving as a major account for cancer‐related death . Allowing for the indistinct symptoms of early‐stage CRC, a majority of the CRC population remained undiagnosed until their advanced stage . Moreover, the patients with CRC accompanied by distant metastasis were documented with a 5‐year survival of less than 50%, which stated the significance of diagnosing early CRC.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Allowing for the indistinct symptoms of early-stage CRC, a majority of the CRC population remained undiagnosed until their advanced stage. 3 Moreover, the patients with CRC accompanied by distant metastasis were documented with a 5-year survival of less than 50%, which stated the significance of diagnosing early CRC. Hence, locating novel biomarkers that particularly indicated the pathogenesis of CRC appeared vital for subsequent diagnosis and prognostic estimation among CRC sufferers.…”

Section: Introductionmentioning

confidence: 99%

Regulatory effects of lncRNA ATB targeting miR‐200c on proliferation and apoptosis of colorectal cancer cells

Gao

Zhou

Wang

et al. 2019

J of Cellular Biochemistry

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This investigation was intended to elucidate whether long noncoding RNA (lncRNA)‐activated by transforming growth factor‐β (ATB) interacting with miR‐200c could mediate colorectal cancer (CRC) progression, offering potential strategies for diagnosing and treating CRC. Here totally 315 patients with CRC were recruited, and their CRC tissues and adjacent normal tissues were gathered. Concurrently, four colon cancer cell lines (ie, SW620, Lovo, HCT116, and SW480) and the human colon mucosal epithelial cell line (NCM460) were also purchased. Moreover, si‐ATB, si‐NC, miR‐200c mimic, miR‐200c inhibitor, and miR‐NC were prepared for transfection into the CRC cells, and their effects on CRC cell lines were evaluated based on the conduction of 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay, colony formation assay, and flow cytometry assay. Eventually, the Luciferase reporter gene assay was carried out to judge if there existed a targeted relationship between ATB and miR‐200c. The results of Cox regression analyses suggested that overexpressed lncRNA ATB, underexpressed miR‐200c, poor tumor differentiation, lymph‐vascular invasion, and perineural invasion were symbolic of shortened survival of the patients with CRC (all P < .05). Besides, transfection of pcDNA3.1‐ATB and miR‐200c inhibitor could boost the viability and proliferation of Lovo and SW620 cell lines (all P < .05). Meanwhile, the expressions of p53 and p21 were also reduced under treatments of pcDNA3.1‐ATB and miR‐200c inhibitor (P < .05). In addition, CDK2 seemed to reverse the contribution of miR‐200c to intensifying viability and proliferation of Lovo and SW420 cell lines (P < .05). Furthermore, ATB might downregulate miR‐200c expression by targeting it (P < .05), and CDK2 was subjected to dual regulation of both ATB and miR‐200c (P < .05). In conclusion, the lncRNA ATB/miR‐200c/CDK2 signaling was responsible for intensified proliferation and prohibited apoptosis of CRC cells, which might provide effective approaches for diagnosing and treating CRC.

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“…In the United States, more than 500,000 individuals are diagnosed with CD and the incidence and prevalence of this disorder have been increasing (Cosnes, Seksik, & Cortot, ). Moreover, CD enhances the risk of colorectal cancer and affects patients’ prognosis (Negoi, Runcanu, Paun, & Beuran, ).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic potentials of adenosine receptors agonists and antagonists in colitis; Current status and perspectives

Bahreyni

Samani

Khazaei

et al. 2017

Journal Cellular Physiology

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Increasing evidence suggests that adenosine is dysregulated in ulcerative colitis (UC), potentially affecting UC pathogenesis, diagnosis, and therapy. Dysregulation of the activity of adenosine generating enzymes including adenosine deaminase in serum of patients with acute colitis supports the role of this omnipresent metabolite in the pathogenesis of colitis. Adenosine regulates inflammatory responses including epithelial barrier hyper-permeability, myeloperoxidase activity, and neuromuscular motility in colitis, supporting the therapeutic potency of adenosine receptors agonists and antagonists in this disease. Depending upon the adenosine receptor subtype, activation or suppression of the receptor with pharmacological agonists or antagonists attenuates colitis pathological symptoms in colitis model. This review summarizes the role of adenosine receptors agonists and antagonists in the pathogenesis of colitis for a better understanding and hence a better management of this disease.

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Right Hemihepatectomy for Colon Cancer Metachronous Liver Metastasis in a Patient with Crohn\'s Disease: Case Report and Review of the Literature

Cited by 5 publications

References 17 publications

A 3-circular RNA signature as a noninvasive biomarker for diagnosis of colorectal cancer

A 3-circular RNA signature as a noninvasive biomarker for diagnosis of colorectal cancer

Regulatory effects of lncRNA ATB targeting miR‐200c on proliferation and apoptosis of colorectal cancer cells

Therapeutic potentials of adenosine receptors agonists and antagonists in colitis; Current status and perspectives

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