Right Hemisphere Dysfunction and Schizophrenia

West, EricD.; Kellett, John R.

doi:10.1016/s0140-6736(84)90392-1

Cited by 7 publications

(3 citation statements)

References 6 publications

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“…These findings are in contrast with the hypofrontality, which has repeatedly been reported in studies with chronic schizophrenic patients (Buchsbaum et al 1982;Farkas et al 1984;Cohen et al 1987;Volkow et al 1987;Weinberger et al 1988;Wolkin et al 1988;Buchsbaum et al 1990;Andreasen et al 1992;Wolkin et al 1992;Siegel et al 1993). In addition, our data corroborate reports on alterations of interhemispheric balance in psychoses (Beaumont and Dimond 1973;Wexler and Heninger 1979;Magaro and Page 1983;West 1984;Gur et al 1989) and suggest that a functional right hemispheric overactivity may be associated with acute endogenous or hallucinogen-induced psychotic syndromes (Oepen et al 1987;Hermle et al 1992). Finally, until recently, the thalamus has played a remarkably minor role in theories on the etiology of schizophrenia.…”

Section: Neurometabolic Effects Of the Drugs And Correlations With Pssupporting

confidence: 90%

Neurometabolic Effects of Psilocybin, 3,4-Methylenedioxyethylamphetamine (MDE) and d-Methamphetamine in Healthy Volunteers A Double-Blind, Placebo-Controlled PET Study with [18F]FDG

Gouzoulis-Mayfrank

1999

Neuropsychopharmacology

181

100

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The neurometabolic effects of the hallucinogen psilocybin (PSI; 0.2 mg/kg), the entactogen 3,4-methylenedioxyethylamphetamine (MDE; 2 mg/kg) and the stimulant d-methamphetamine (METH; 0.2-0.4 mg/kg) and the drugs' interactions with a prefrontal activation taskwere investigated in a double-blind, placebo-controlled human [F-18]fluorodeoxyglucoseFDG-positron emission tomographicPET study (each group: n ϭ 8 Experimental studies of cerebral blood flow and metabolism with psychoactive drugs in humans aim to explore the interaction of these drugs with human brain function. Recent studies with hallucinogenic, "mind-expanding" drugs in healthy subjects provided evidence in favor of an altered functional interhemispheric balance From the Department of Psychiatry and Psychotherapy (EG-M, BT, HS), University of Technology (RWTH), Aachen, Germany; Department of Nuclear Medicine (MS, OS, CA, UB), University of Technology (RWTH), Aachen, Germany; Department of Psychiatry (MS), University of Ulm, Ulm, Germany; Pharmaceutical Institute (K-AK), University of Tübingen, Tübingen, Germany; Psychiatric and Neurological Hospital Christophsbad (LH), Göppingen, Germany.Address correspondence to: E. Gouzoulis-Mayfrank, M.D., Department of Psychiatry and Psychotherapy, University of Technology (RWTH), Pauwelsstrasse 30, D-52074 Aachen, Germany.Received March 14, 1998, accepted July 20, 1998 566 E. Gouzoulis-Mayfrank et al. N EUROPSYCHOPHARMACOLOGY 1999 -VOL . 20 , NO . 6 with right hemispheric dominance and an increased activity in frontocortical regions after acute administration of mescaline, psilocybin, or ketamine (Hermle et al. 1992; Vollenweider et al. 1997a, b). The most profound increase in metabolism was found in the anterior cingulate (Vollenweider et al. 1997a(Vollenweider et al. , 1997b, which is linked to both emotional and attentional functions (Vogt et al. 1992;Devinsky et al. 1995;Murtha et al. 1996). These functions are, in turn, tightly connected to both the effects of hallucinogens and the symptoms of schizophrenic and schizophrenia-spectrum psychoses.Hallucinogenic drug-induced states can be used as models for acute endogenous psychotic states in psychiatric research (Hermle et al. 1992; Vollenweider et al. 1997a, b;Gouzoulis-Mayfrank et al. 1998). Within the framework of this model psychosis paradigm neurometabolic data from the above-mentioned studies can be interpreted in the sense that acute psychotic states with prominent positive symptoms are linked to increased activity in frontal neocortical, and limbic areas. This is in contrast to the majority of functional neuroimaging studies with schizophrenic patients, which demostrate hypofrontality both in resting states (Buchsbaum et al. 1982;Farkas et al. 1984;Wolkin et al. 1988;Siegel et al. 1993) and under cognitive tasks believed to employ frontal brain areas (Cohen et al. 1987;Weinberger et al. 1988;Buchsbaum et al. 1990;Andreasen et al. 1992). However, most of these studies were performed with chronically ill patients on various neuroleptic medications, a...

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Section: Neurometabolic Effects Of the Drugs And Correlations With Pssupporting

confidence: 90%

Neurometabolic Effects of Psilocybin, 3,4-Methylenedioxyethylamphetamine (MDE) and d-Methamphetamine in Healthy Volunteers A Double-Blind, Placebo-Controlled PET Study with [18F]FDG

Gouzoulis-Mayfrank

1999

Neuropsychopharmacology

181

100

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“…Cazzullo, Gambini, Pieri and Scarone (1984) have suggested that the right hemisphere is primarily involved in the initial phases of schizophrenia, while left hemisphere malfunctioning is more characteristic of chronic patients. Some researchers have suggested that even in chronic schizophrenic patients, there is evidence of performance patterns that are consistent with right hemisphere dysfunction (Erwin, & Rosenbaum, 1979;West, 1984). Therefore, a secondary purpose of the present study was to examine whether chronic schizophrenics show symptoms of right hemisphere dysfunction, specifically right parietal lobe dysfunction.…”

mentioning

confidence: 90%

Constructional Abilities in Persons with Chronic Schizophrenia

Cermak¹,

Eimon²,

Eimon³

et al. 1992

Occupational Therapy in Mental Health

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“…Using divided visual field studies, many of them have found a dysfunction of the left hemisphere (Beaumont and Dimond, 1973;Tomer et aI., 1982). A few authors have claimed a dysfunction of the right hemisphere (Schweitzer, 1978;Venables, 1984, West, 1984Cutting, 19851 1990;Oepen et al. 1988).…”

Section: Introductionmentioning

confidence: 99%

Blood Flow and Cerebral Laterality in the Mescaline Model of Psychosis

Hermle

Spitzer²

1998

Pharmacopsychiatry

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The psychological, neuropsychological, and neurometabolic effects of the hallucinogenic agent mescaline were investigated in 12 normal male volunteers. Between 3 1/2 and 4 hours after drug intake, mescaline produced an acute psychotomimetic state, as measured by the BPRS and PDS-P. The APZ questionnaire revealed the specific effects of mescaline in the visual system. Neuropsychological effects were studied with a face/non-face decision task with known right hemisphere advantage, in which mescaline induced a decrease in functioning of the right hemisphere. In functional brain imaging using SPECT, mescaline produced a "hyperfrontal" pattern with an emphasis on the right hemisphere, which was correlated with mescaline-induced psychotomimetic psychopathology. Our findings question the validity of the concept of hypofrontality as an explanation for acute psychotic symptomatology.

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Right Hemisphere Dysfunction and Schizophrenia

Cited by 7 publications

References 6 publications

Neurometabolic Effects of Psilocybin, 3,4-Methylenedioxyethylamphetamine (MDE) and d-Methamphetamine in Healthy Volunteers A Double-Blind, Placebo-Controlled PET Study with [18F]FDG

Neurometabolic Effects of Psilocybin, 3,4-Methylenedioxyethylamphetamine (MDE) and d-Methamphetamine in Healthy Volunteers A Double-Blind, Placebo-Controlled PET Study with [18F]FDG

Constructional Abilities in Persons with Chronic Schizophrenia

Blood Flow and Cerebral Laterality in the Mescaline Model of Psychosis

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