Right hippocampus size is negatively correlated with leptin serum levels in bipolar disorder

Vianna-Sulzbach, Miréia; Rocha, Natália Pessoa; Teixeira, Antônio Lúcio; Rosa, Eduarda Dias da; Goldani, André Akira Sueno; Anna, M Kauer-Sant; Gama, Clarissa Severino

doi:10.1016/j.psychres.2015.09.040

Cited by 5 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Technical details are described elsewhere. [48][49][50] All images were processed and checked by the same researcher. Our analyses focused on total GM volume (cortical + subcortical).…”

Section: Biomarkersmentioning

confidence: 99%

Telomere Length and CCL11 Levels are Associated With Gray Matter Volume and Episodic Memory Performance in Schizophrenia: Evidence of Pathological Accelerated Aging

Czepielewski

Massuda

Panizzutti

et al. 2017

Schizophrenia Bulletin

Self Cite

View full text Add to dashboard Cite

Schizophrenia (SZ) is associated with increased somatic morbidity and mortality, in addition to cognitive impairments similar to those seen in normal aging, which may suggest that pathological accelerated aging occurs in SZ. Therefore, we aim to evaluate the relationships of age, telomere length (TL), and CCL11 (aging and inflammatory biomarkers, respectively), gray matter (GM) volume and episodic memory performance in individuals with SZ compared to healthy controls (HC). One hundred twelve participants (48 SZ and 64 HC) underwent clinical and memory assessments, structural MRI, and had their peripheral blood drawn for biomarkers analysis. Comparisons of group means and correlations were performed. Participants with SZ had decreased TL and GM volume, increased CCL11, and worse memory performance compared to HC. In SZ, shorter TL was related to increased CCL11, and both biomarkers were related to reduced GM volume, all of which were related to worse memory performance. Older age was only associated with reduced GM, but longer duration of illness was related with all the aforementioned variables. Younger age of disease onset was associated with increased CCL11 levels and worse memory performance. In HC, there were no significant correlations except between memory and GM. Our results are consistent with the hypothesis of accelerated aging in SZ. These results may indicate that it is not age itself, but the impact of the disease associated with a pathological accelerated aging that leads to impaired outcomes in SZ.

show abstract

“…Technical details are described elsewhere. [48][49][50] All images were processed and checked by the same researcher. Our analyses focused on total GM volume (cortical + subcortical).…”

Section: Biomarkersmentioning

confidence: 99%

Telomere Length and CCL11 Levels are Associated With Gray Matter Volume and Episodic Memory Performance in Schizophrenia: Evidence of Pathological Accelerated Aging

Czepielewski

Massuda

Panizzutti

et al. 2017

Schizophrenia Bulletin

Self Cite

View full text Add to dashboard Cite

show abstract

“…Among the hormones secreted by adipose tissue, leptin appears to be involved with depressive disorders, including MDD and depression in BD (36)(37)(38)(39)(71)(72)(73). Leptin was described in 1995 as a hormone responsible for the feeling of satiety, which acts mainly on the CNS and inhibits the action of orexigenic neurons and stimulates the action of anorectic neurons, in addition to increasing basal energy expenditure and being secreted in proportion to the adipose tissue stock (74).…”

Section: Discussionmentioning

confidence: 99%

Ketamine study: Protocol for naturalistic prospective multicenter study on subcutaneous ketamine infusion in depressed patients with active suicidal ideation

Anzolin

Goularte²,

Pinto³

et al. 2023

Front. Psychiatry

View full text Add to dashboard Cite

BackgroundPsychiatric disorders are associated with more than 90% of reported suicide attempts worldwide, but few treatments have demonstrated a direct effect in reducing suicide risk. Ketamine, originally an anesthetic, has been shown anti-suicide effects in clinical trials designed to treat depression. However, changes at the biochemical level were assessed only in protocols of ketamine with very limited sample sizes, particularly when the subcutaneous route was considered. In addition, the inflammatory changes associated with ketamine effects and their correlation with response to treatment, dose-effect, and suicide risk warrant further investigation. Therefore, we aimed to assess whether ketamine results in better control of suicidal ideation and/or behavior in patients with depressive episodes and whether ketamine affects psychopathology and inflammatory biomarkers.Materials and methodsWe report here the design of a naturalistic prospective multicenter study protocol of ketamine in depressive episodes carried out at Hospital de Clínicas de Porto Alegre (HCPA) and Hospital Moinhos de Vento (HMV). The study was planned to recruit adult patients with Major depressive disorder (MDD) or Bipolar disorder (BD) types 1 or 2, who are currently in a depressive episode and show symptoms of suicidal ideation and/or behavior according to the Columbia-Suicide Severity Rating Scale (C-SSRS) and have been prescribed ketamine by their assistant psychiatrist. Patients receive ketamine subcutaneously (SC) twice a week for 1 month, but the frequency can be changed or the dose decreased according to the assistant physician’s decision. After the last ketamine session, patients are followed-up via telephone once a month for up to 6 months. The data will be analyzed using repeated measures statistics to evaluate the reduction in suicide risk as a primary outcome, as per C-SSRS.DiscussionWe discuss the need for studies with longer follow-ups designed to measure a direct impact on suicide risk and that additional information about the safety and tolerability of ketamine in particular subset of patients such as those with depression and ideation suicide. In line, the mechanism behind the immunomodulatory effects of ketamine is still poorly understood.Trial registrationhttps://clinicaltrials.gov/, identifier NCT05249309.

show abstract

Volumetric brain magnetic resonance imaging predicts functioning in bipolar disorder: A machine learning approach

Sartori

Reckziegel

Passos

et al. 2018

Journal of Psychiatric Research

View full text Add to dashboard Cite

Right hippocampus size is negatively correlated with leptin serum levels in bipolar disorder

Cited by 5 publications

References 10 publications

Telomere Length and CCL11 Levels are Associated With Gray Matter Volume and Episodic Memory Performance in Schizophrenia: Evidence of Pathological Accelerated Aging

Telomere Length and CCL11 Levels are Associated With Gray Matter Volume and Episodic Memory Performance in Schizophrenia: Evidence of Pathological Accelerated Aging

Ketamine study: Protocol for naturalistic prospective multicenter study on subcutaneous ketamine infusion in depressed patients with active suicidal ideation

Volumetric brain magnetic resonance imaging predicts functioning in bipolar disorder: A machine learning approach

Contact Info

Product

Resources

About