Right lung transplantation with a left-to-right inverted anastomosis in a rat model

A modified orthotopic left lung transplantation model in rats

“…A cursory review of PubMed reveals approximately 100 papers utilizing rat or mouse kidney transplantation models in 2023, whereas only about 10 papers employ rat or mouse lung transplantation models within the same timeframe. Despite notable modifications in rodent lung transplantation models in recent years [ 6 , 7 ], there remains no discernible increase in the utilization of such models despite advancements in technology and economy. Conversely, there has been a significant rise in papers utilizing the lung hilar clamping model to simulate lung transplantation, owing to its simplicity [ 8 ].…”

Commentary: Back(ward) to the future—novel technique of inverted left lung–right chest lung transplant in rats

“…In this issue of JTCVS Open , Huang and colleagues 8 turn the tables of the animal model-to-human paradigm with a technical report of a novel “inverted” rat single-lung transplant procedure inspired by the Kyoto group's successful human lobar lung transplantation of a right lower lobe implanted into the left chest. 9 Elegantly described and depicted in the accompanying video, a rat donor left lung is rotated 180° and transplanted to the recipient's right chest using a standard 3-cuff anastomotic technique (inverted left-right transplant, IL-RT).…”