“…Data collection took place through the systematic observation of the flushing procedure using a structured checklist created by the authors based on INS and ANVISA guidelines, as well as evidence from the literature on the subject. [1][2][3]6 The observation checklist was divided into 4 sections: (1) identification of the observation: date, time, unit, observer, participant code; (2) flushing preparation: preparation bottle, solution, and syringe diameter used; (3) characterization of intravenous therapy: type of infusion, number of items administered, manipulated vascular access device; and (4) flushing procedure: patency assessment, time of performance (before, during, and after drug administration), volume administered, and technique used in the procedure (see Supplemental Appendix A; http://links. lww.com/JIN/A109).…”