Right Portal Vein Embolization Before Right Hepatectomy for Unilobar Colorectal Liver Metastases Reduces the Intrahepatic Recurrence Rate

Abstract

This study showed that PVE reduces intrahepatic recurrence rate after right hepatectomy for unilobar CLM.

Sinusoidal obstruction syndrome compromises liver regeneration in patients undergoing two-stage hepatectomy with portal vein embolization

“…4 There were 78 patients presenting with multiple and bilobar CLM for whom clearance of the left hemi-liver was feasible during the 1st-stage hepatectomy and in whom the FRL volume before PVE was less than 30%, in those with normal liver parenchyma; or 40%, in those with a liver injured by previous chemotherapy. 7,8 …”

“…They include age, sex, and comorbidities such as diabetes mellitus, alcohol consumption, obstructive jaundice, and malnutrition. 7 However, the effect of chemotherapy-induced liver injury on liver regeneration after PVE has not yet been evaluated in humans. The aim of this study was to evaluate the effect of chemotherapy-induced liver injury on liver regeneration after PVE, and on early postoperative outcome after major liver resection, in patients scheduled to undergo TSH for multiple bilobar CLM.…”

Two-stage hepatectomy for multiple bilobar colorectal liver metastases

“…There are two modifications for performing a TSH: with or without PVE. In brief, percutaneous PVE following first-stage hepatectomy is performed if the FRL volume, estimated by three-dimensional computed tomography (3D-CT) after the first stage, is less than 30 per cent in healthy liver and less than 40 per cent in liver heavily subjected to systemic chemotherapy 17,18 in order to limit the risk of postoperative liver failure after the second stage.…”

Kolorektale Leberfiliae

“…Vor allem bei bilobärem Befall mit geplanter Kombination von Resektion und lokaler Ablation bestehen diesbezüglich noch viele offene Fragen. Überraschenderweise wurde beobachtet, dass bei Patienten mit präope-rativer Pfortaderembolisation vor Hemihepatektomie rechts Rezidive nur in 26% aller Fälle in der Restleber auftraten, verglichen mit einer intrahepatischen Rezidivrate von 76% bei vergleichbaren Patienten nach Hemihepatektomie rechts, die direkt operiert wurden [28].…”