Right-sided vagus nerve stimulation reduces generalized seizure severity in rats as effectively as left-sided

Krahl, Scott E.; Senanayake, Shayani S.; Handforth, Adrian

doi:10.1016/s0920-1211(03)00122-0

Cited by 43 publications

(22 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There were no significant cardiorespiratory events reported neither in the immediate post-operative period nor in the longer follow-up. Right-sided VNS is an off-label usage of VNS therapy due to potential cardiac side effects; however, concerns about those cardiac effects of R-VNS are based on animal studies, which show some inconsistencies [42][43][44]. Cases reported in the literature showed clinical efficacy equal or even superior to left-sided stimulation without significant side effects in most of the cases [15,16,45], raising the question of whether R-VNS should be offered to patients who do not show good response after L-VNS therapy or even if bilateral VNS therapy could be safely attempted [16].…”

Section: Discussionmentioning

confidence: 99%

Vagus nerve stimulation therapy for treatment-resistant epilepsy: A 15-year experience at a single institution

Galbarriatu

Pomposo

Aurrecoechea

et al. 2015

Clinical Neurology and Neurosurgery

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Vagus nerve stimulation therapy for treatment-resistant epilepsy: A 15-year experience at a single institution

Galbarriatu

Pomposo

Aurrecoechea

et al. 2015

Clinical Neurology and Neurosurgery

View full text Add to dashboard Cite

“…In one study, a cuff electrode was implanted on the left or right cervical vagus nerve in two groups of rats. [16] After two days, VNS was initiated, then PTZ was injected. The highest seizure stage attained within 15 minutes was rated by a blinded observer.…”

Section: Left- Versus Right-sided Vagus Nerve Stimulationmentioning

confidence: 99%

Vagus nerve stimulation for epilepsy: A review of the peripheral mechanisms

Krahl

2012

Surg Neurol Int

125

View full text Add to dashboard Cite

Vagus nerve stimulation (VNS) is a unique epilepsy treatment in that a peripheral intervention is used to treat a disease that is entirely related to pathological events occurring within the brain. To understand how stimulation of the vagus nerve can be used to stop seizures, an understanding of the peripheral anatomy and physiology of the vagus nerve is essential. The peripheral aspects of the vagus nerve are discussed in this review, with an explanation of which fibers and branches are involved in producing these antiepileptic effects, along with speculation about the potential for improving the therapy.

show abstract

“…Although VNS typically involves stimulation of the left vagus nerve at the cervical level, Zabara (1992) reported right and left VNS to be equally effective in controlling seizures in dogs; and more recently, stimulation of the right vagus nerve has been shown to be as effective in suppressing seizures in rats as stimulation of the left vagus (Krahl et al, 2003). It is not clear whether activation of the LC via vagal afferents would be expected to produce uniform release of NE throughout its terminal fields.…”

Section: Vagus Nerve -Locus Coeruleus Connectionmentioning

confidence: 99%

Increased extracellular concentrations of norepinephrine in cortex and hippocampus following vagus nerve stimulation in the rat

Roosevelt¹,

et al. 2006

View full text Add to dashboard Cite

The vagus nerve is an important source of afferent information about visceral states and it provides input to the locus coeruleus (LC), the major source of norepinephrine (NE) in the brain. It has been suggested that the effects of electrical stimulation of the vagus nerve on learning and memory, mood, seizure suppression, and recovery of function following brain damage are mediated, in part, by the release of brain NE. The hypothesis that left vagus nerve stimulation (VNS) at the cervical level results in increased extracellular NE concentrations in the cortex and hippocampus was tested at four stimulus intensities 0.0, 0.25, 0.5, and 1.0 mA. Stimulation at 0.0 and 0.25 mA had no effect on NE concentrations, while the 0.5 mA stimulation increased NE concentrations significantly in the hippocampus (23%), but not the cortex. However, 1.0 mA stimulation significantly increased NE concentrations in both the cortex (39%) and hippocampus (28%) bilaterally. The increases in NE were transient and confined to the stimulation periods. VNS did not alter NE concentrations in either structure during the inter-stimulation baseline periods. No differences were observed between NE levels in the initial baseline and the post-stimulation baselines. These findings support the hypothesis that VNS increases extracellular NE concentrations in both the hippocampus and cortex.

show abstract

Right-sided vagus nerve stimulation reduces generalized seizure severity in rats as effectively as left-sided

Cited by 43 publications

References 7 publications

Vagus nerve stimulation therapy for treatment-resistant epilepsy: A 15-year experience at a single institution

Vagus nerve stimulation therapy for treatment-resistant epilepsy: A 15-year experience at a single institution

Vagus nerve stimulation for epilepsy: A review of the peripheral mechanisms

Increased extracellular concentrations of norepinephrine in cortex and hippocampus following vagus nerve stimulation in the rat

Contact Info

Product

Resources

About