Right ventricle-dependent coronary circulation diagnosed by non-invasive ferumoxytol-enhanced 4D cardiac magnetic resonance angiography in pulmonary atresia with intact ventricular septum

Rezkalla, Joshua; Raymundo, Stephanie A; Renella, Pierangelo

doi:10.1017/s1047951122003055

Cited by 1 publication

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“…Due to speed and simplicity, coronary CTA and/or conventional angiography are often used in clinical practice for coronary evaluations in both adults and children. Our group has successfully applied cardiac phase-resolved 4D FE-MRA in very small babies to accurately delineate complex coronary anatomy ( Figure 12 ) [ 68 ].…”

Section: Future Applicationsmentioning

confidence: 99%

Ferumoxytol-Enhanced Cardiac Magnetic Resonance Angiography and 4D Flow: Safety and Utility in Pediatric and Adult Congenital Heart Disease

Renella

Prosper³

et al. 2022

Children

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Cardiac magnetic resonance imaging and angiography have a crucial role in the diagnostic evaluation and follow up of pediatric and adult patients with congenital heart disease. Although much of the information required of advanced imaging studies can be provided by standard gadolinium-enhanced magnetic resonance imaging, the limitations of precise bolus timing, long scan duration, complex imaging protocols, and the need to image small structures limit more widespread use of this modality. Recent experience with off-label diagnostic use of ferumoxytol has helped to mitigate some of these barriers. Approved by the U.S. FDA for intravenous treatment of anemia, ferumoxytol is an ultrasmall superparamagnetic iron oxide nanoparticle that has a long blood pool residence time and high relaxivity. Once metabolized by macrophages, the iron core is incorporated into the reticuloendothelial system. In this work, we aim to summarize the evolution of ferumoxytol-enhanced cardiovascular magnetic resonance imaging and angiography and highlight its many applications for congenital heart disease.

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Section: Future Applicationsmentioning

confidence: 99%