Right ventricular 2D speckle-tracking echocardiography in children with osteosarcoma under chemotherapy

Khairat, Ibtsam; Khalfallah, Mohamed Tahar; Shaban, Aliaa; Farag, Ibrahim Abu; El-Kady, Asmaa M

doi:10.1186/s43044-019-0028-9

Cited by 13 publications

(10 citation statements)

References 22 publications

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“…Compared to other echocardiographic techniques, RV speckle-tracking identified RV dysfunction early. This is consistent with Khairat et al [12] who discovered increased incidence of RV dysfunction by speckle tracking to 12% after 10 months from anthracycline chemotherapy among children with osteosarcoma. Xu et al [13] used three-dimensional echocardiography to assess subclinical right ventricle deterioration among 95 women with breast cancer, who received epirubicin (360 mg/m 2 ), they also found significant reduction in 3D-RVGLS at the end of the treatment course and at 12 months after it.…”

Section: Discussionsupporting

confidence: 92%

Right Ventricle Function Evaluation by 2D Transthoracic-Echocardiography in Breast Cancer Patients Undergoing Anthracycline Chemotherapy, A Prospective Cohort Study

Attia¹,

Kamal²,

Merry³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Breast cancer is one of the most prevalent types of cancers among women in Egypt with incidence rates of 48.8 per 100.000 women. Anthracyclines are the drugs of choice for adjuvant chemotherapy in high-risk patients, however, their use is limited due to their cardiotoxicity. In animal models treated with anthracyclines, right ventricle (RV) dysfunction is thought to be an independent prognostic factor and it's possible that it could be an early indicator of subclinical left ventricle (LV) dysfunction. Therefore, further research is required to study the cardiotoxic effect of anthracycline drugs on the RV using different 2D echocardiographic modalities. Subjects and Methods: A total number of 40 newly diagnosed breast cancer patients who were planned to receive doxorubicin therapy for 37 of them and epirubicin for 3 patients were prospectively recruited. Serial 2 D echocardiograms including speckle-tracking were done at baseline, 3 months later, and 6 months later. Results: RV dysfunction was detected more by right ventricle global longitudinal strain (RVGLS) after six months of anthracycline-based chemotherapy (-22.85±1.31 vs. -19.30±2.30, P value 0.001). ROC curve revealed a total anthracycline cumulative dose of 416 mg/m 2 with the highest sensitivity and specificity of RV dysfunction. Conclusion: RVGLS surpassed other traditional 2D metrics in identifying subclinical RV disease, and the total anthracycline cumulative dose is strongly linked to the incidence of chemotherapy related cardiotoxicity to the right ventricle. 2D speckle-tracking is noninvasive and feasible modality that can be used to detect early anthracycline-induced cardiotoxicity.

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Section: Discussionsupporting

confidence: 92%

Right Ventricle Function Evaluation by 2D Transthoracic-Echocardiography in Breast Cancer Patients Undergoing Anthracycline Chemotherapy, A Prospective Cohort Study

Attia¹,

Kamal²,

Merry³

et al. 2023

The Egyptian Journal of Hospital Medicine

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“…There were multisystem damage, water and electrolyte disorder, and other pathological changes in the bodies of children with severe pneumonia combined with heart failure [32]. Two-dimensional speckle tracking imaging technology could quantitatively detect children's right ventricular longitudinal strain and further assess right ventricular search function [33]. In addition, RVGLS, FWGLS, and IVSGLS levels of the children with severe pneumonia combined with heart failure were significantly enhanced after milrinone treatment compared with those after conventional treatment.…”

Section: Discussionmentioning

confidence: 99%

Modeling of Right Ventricular Longitudinal Strain detection in Images using Statistical Analysis of Cardiac function in Severe Infantile Pneumonia by Milrinone

Hong

Chen

2023

Preprint

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After severe infantile pneumonia accompanied by heart failure, the evaluation of cardiac function using two-dimensional speckle tracking-based ultrasonic imaging technology was looked into both before and after milrinone treatment. The study’s research subjects included 82 kids with severe pneumonia and heart failure. According to therapeutic methods, they were divided into the Conv group (conventional treatment for 31 cases) and the Milrinone group (conventional treatment combined with milrinone for 31 cases). Conventional children’s ultrasonocardiography was collected to implement wavelet threshold denoising before and after treatment. The modeling was performed using statistical methods, i.e., Canny arithmetic was used to check the edge outlines of abnormal areas. Besides, the global search block matching method was utilized to monitor three consecutive cardiac cycle images. The differences between cardiac function, right ventricular longitudinal strain after two-dimensional speckle tracking imaging, serum inflammatory factors (interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α, and brain natriuretic peptide (BNP)), and complication rate of children were evaluated. In comparison to Gaussian low-pass filter and mean filter techniques, the results showed that mean square error (MSE), peak signal to noise ratio (PSNR), and mean structural similarity (MSSIM) of pictures following wavelet threshold denoising were all superior. When Canny arithmetic and global search block matching were used, the cardiac speckle tracking time was 0.07 ms, and the detection accuracy was 95.5%. Compared with the Conv and Milrinone groups, normal respiration, pulmonary moist rale disappearance, and liver recovery time were all shortened (P<0.05). Besides, children’s cardiac functions, including aortic peak flow velocity, left ventricular ejection fraction, corrected ejection time, and stroke volume index, significantly increased compared with those of Conv group and Milrinone group (P<0.05). Heart rate (HR), the overall longitudinal strain of right ventricle during systole, the overall longitudinal strain of the free wall, and the overall longitudinal strain of the interventricular septum were remarkably decreased (P<0.05). Compared with the Conv and Milrinone groups, serum IL-6, IL-10, TNF-α, and BNP levels of children were remarkably reduced (P<0.05). The total complication rate of the children in Conv group and Milrinone group were 16.1% (5/31) and 3.2% (1/31), respectively. The differences between the two groups were statistically significant (P<0.05). In conclusion, two-dimensional speckle tracking imaging can benefit from employing image processing technology to improve detection precision. When used as a clinical treatment for severe infantile pneumonia and heart failure, milrinone can lower the level of inflammatory factors in children’s bodies. Furthermore, it improved children’s cardiac function, reduced complication rate, and was beneficial to the prognosis of children.

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“…However, the inverse relation between the BSA of underweighted ASD children and adolescents was responsible for the exaggerated impact of ASD on increasing the indexed right-sided dimensions to BSA before the time of closure [ 26 ]. Moreover, the young age and small BSA had a positive impact on GLS and RV free wall LS beside the impact of ASD, which was significantly higher in children and adolescents [ 27 ]. Generally, the BSA has a significant impact on echocardiographic parameters of growing ages than adults [ 26 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

The changes in biventricular remodelling and function after atrial septal defect device closure and its relation to age of closure

et al. 2020

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Background The trans-catheter closure of atrial septal defect (ASD) usually has a rapid impact on biventricular remodelling and functions. Whether the transcatheter closure of ASD at early childhood or at adulthood age would affect the improvement in biventricular dimensions and functions remains an area of active research. Results This prospective observational study enrolled 70 subjects (50 ASD cases and 20 control subjects). Tissue Doppler imaging (TDI) and strain (S) were performed for the control group and ASD patients at baseline and at 24 h and 1 month after ASD device closure. The total ASD group was subdivided into two subgroups: group-1—children and adolescent with ASD, who underwent transcatheter closure at age ≤ 19 years; group-2—adult who underwent ASD device closure at age > 19 years old. The right and left ventricular global longitudinal systolic strain (RV/LV-GLS) and RV free wall longitudinal strain (RV free wall LS) showed a significant decline after 24 h of device closure (RVGLS-P = 0.001, LVGLS-P = 0.048, RV free wall LS-P < 0.001). However, after a 1-month follow-up, the LVGLS increased in comparison with 24 h changes after device closure (P = 0.038). The baseline mean value of RV free wall LS of G2 was significantly lower than G1 value (P < 0.001). There was no statistically significant difference between the 2 age subgroups regarding biventricular GLS and RV free wall LS changes after device closure. The changes in LV diastolic function immediately and after 1 month of device closure showed a statistically significant change in e′ and its delta change value in group-2 in comparison with its baseline values and to group-1 delta changes (P = 0.002, P = 0.011, P = 0.019, respectively). Conclusion The ASD transcatheter closure reduced biventricular global and RV free wall longitudinal systolic strain within 1 day of intervention and was associated with a short-term improvement in the LV-GLSS after a 1-month duration. The progressive increase in LV preload results in its strain growth and reduction in diastolic function after transcatheter ASD closure. The older age at the time of ASD device closure was associated with a significant decrease in the RV free wall LS and septal e′ velocity towards abnormality.

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Right ventricular 2D speckle-tracking echocardiography in children with osteosarcoma under chemotherapy

Cited by 13 publications

References 22 publications

Right Ventricle Function Evaluation by 2D Transthoracic-Echocardiography in Breast Cancer Patients Undergoing Anthracycline Chemotherapy, A Prospective Cohort Study

Right Ventricle Function Evaluation by 2D Transthoracic-Echocardiography in Breast Cancer Patients Undergoing Anthracycline Chemotherapy, A Prospective Cohort Study

Modeling of Right Ventricular Longitudinal Strain detection in Images using Statistical Analysis of Cardiac function in Severe Infantile Pneumonia by Milrinone

The changes in biventricular remodelling and function after atrial septal defect device closure and its relation to age of closure

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