Background
Cardiac dark-blood turbo spin-echo (TSE) imaging is sensitive to through-plane motion, resulting in myocardial signal reduction.
Purpose
To propose and validate reverse double inversion-recovery (RDIR)—a dark-blood preparation with improved motion robustness for the cardiac dark-blood TSE sequence.
Study Type
Prospective.
Population
Healthy volunteers (n=10) and patients (n=20)
Field Strength
1.5T (healthy volunteers) and 3T (patients)
Assessment
Compared to double inversion recovery (DIR), RDIR swaps the two inversion pulses in time and places the slice-selective 180° in late-diastole of the previous cardiac cycle to minimize slice mis-registration. RDIR and DIR were performed in the same left-ventricular basal short-axis slice. Healthy subjects were imaged with two preparation slice-thicknesses, 110% and 200%, while patients were imaged using a 200% slice-thickness only. Images were assessed quantitatively, by measuring the myocardial signal heterogeneity and the extent of dropout, and also qualitatively on a 5-point scale.
Statistical Tests
Quantitative and qualitative data were assessed with Student’s t-test and Wilcoxon signed-rank test, respectively.
Results
In healthy subjects, RDIR with 110% slice-thickness significantly reduced signal heterogeneity in both the left ventricle (LV) and right ventricle (RV) (LV: p=0.006, RV: p<0.0001) and the extent of RV dropout (p<0.0001), while RDIR with 200% slice-thickness significantly reduced RV signal heterogeneity (p=0.001) and the extent of RV dropout (p=0.0002). In patients, RDIR significantly reduced RV myocardial signal heterogeneity (0.31 vs. 0.43; p=0.003) and the extent of RV dropout (24% vs. 46%; p=0.0005). LV signal heterogeneity exhibited a trend towards improvement with RDIR (0.12 vs. 0.16; p=0.06). Qualitative evaluation showed a significant improvement of LV and RV visualization in RDIR compared to DIR (LV: p= 0.04, RV: p=0.0007) and a significantly improved overall image quality (p=0.03).
Data Conclusion
RDIR TSE is less sensitive to through-plane motion, potentiating increased clinical utility for black-blood TSE.