Right Ventricular Endomyocardial Biopsy Findings in 25 Patients With Sick Sinus Syndrome

Morimoto, S; Hiramitsu, Shinya; Ohtsuki, Masatsugu; Kato, Shigeru; Kato, Yasuchika; Sugiura, Akira; Miyagishima, Kenji

doi:10.1536/jhj.45.73

Cited by 6 publications

(5 citation statements)

References 19 publications

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“…The other patients continued to have atrial fibrillation. 147 Uemura and colleagues 148 reported on the results of right ventricular EMB in 25 patients admitted for diagnostic evaluation of "sick sinus syndrome" who did not have underlying cardiac disease such as cardiomyopathy or valvular disease. These results were compared with biopsies from 12 normal autopsied hearts.…”

Section: Clinical Scenario 14mentioning

confidence: 99%

“…No mention is made of how these findings might have related to clinical management. 148 On the basis of these reports, the Writing Group recommends that EMB not be performed in the setting of unexplained atrial fibrillation.…”

Section: Clinical Scenario 14mentioning

confidence: 99%

“…Second-or third-degree AV block 50 Frequent myocyte hypertrophy, lymphocytic infiltration, myocyte disarrangement, myocytolysis, and nuclear deformity Myocarditis diagnosed in 6% of patients Uemura et al 148 …”

mentioning

confidence: 99%

See 2 more Smart Citations

The Role of Endomyocardial Biopsy in the Management of Cardiovascular Disease

Cooper¹,

Baughman²,

Feldman³

et al. 2007

Circulation

761

248

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Section: Clinical Scenario 14mentioning

confidence: 99%

Section: Clinical Scenario 14mentioning

confidence: 99%

See 1 more Smart Citation

The Role of Endomyocardial Biopsy in the Management of Cardiovascular Disease

Cooper¹,

Baughman²,

Feldman³

et al. 2007

Circulation

761

248

View full text Add to dashboard Cite

“…Histologically abnormal findings such as myocyte disorganization, interstitial mononuclear cells, and endocardial lesions were only seen in those biopsy specimens from patients with sick sinus syndrome. No mention is made of how these findings might have related to clinical management (148). On the basis of these reports, the Writing Group recommends that EMB not be performed in the setting of unexplained atrial fibrillation.…”

Section: Clinical Scenario 14mentioning

confidence: 99%

The Role of Endomyocardial Biopsy in the Management of Cardiovascular Disease

Cooper¹,

Baughman²,

Feldman³

et al. 2007

Journal of the American College of Cardiology

584

143

View full text Add to dashboard Cite

“…5, 7 In addition, a significant difference in the CMD has been reported between patients with sick sinus syndrome and healthy controls. 8 Furthermore, in a reworsening HF patient with anthracyclineinduced cardiomyopathy, CMD significantly increased with decreased LV contractility after the explant of an LV assist device. 9 Thus, CMD varies depending on the type of heart disease, and sensitively reflects the pathology and condition of HF.…”

mentioning

confidence: 98%

Relationship Between Results of Pathological Evaluation of Endomyocardial Biopsy and Echocardiographic Indices in Patients With Non-Ischemic Cardiomyopathy

Toyosaki,

Mochizuki,

Den

et al. 2023

Circ Rep

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Background: Endomyocardial biopsy (EMB) is a useful modality in diagnosing the origin of cardiomyopathy and the condition of the impaired myocardium. However, the usefulness of obtaining an EMB from the right and left ventricles (RV and LV, respectively), and its associations with echocardiographic parameters, have not been explored. Methods and Results: Ninety-five consecutive patients with non-ischemic cardiomyopathy excluding myocarditis who underwent EMB between July 2017 and May 2019 were studied. Seventy-nine RV and 93 LV biopsy specimens were pathologically analyzed. The relationships among echocardiographic data before EMB and pathologically measured cardiomyocyte diameter (CMD) and interstitial fibrosis (IF) were evaluated. CMD in both LV and RV specimens correlated with echocardiographic LV morphology, but only CMD in the LV was significantly correlated with cardiac function evaluation, including LV ejection fraction, E′ and E/E′. In contrast, there were no significant correlations between IF in either the LV or RV and any echocardiographic parameters measured. Furthermore, CMD of both ventricles was significantly correlated with B-type natriuretic peptide (BNP) concentration at EMB, whereas IF of the LV was barely related and IF of the RV was not significantly correlated with BNP concentrations. Conclusions: Pathologically evaluated CMD of EMB specimens of the LV may be more related to functional parameters for heart failure status and LV geometry on echocardiographic examination, than IF.

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Right Ventricular Endomyocardial Biopsy Findings in 25 Patients With Sick Sinus Syndrome

Cited by 6 publications

References 19 publications

The Role of Endomyocardial Biopsy in the Management of Cardiovascular Disease

The Role of Endomyocardial Biopsy in the Management of Cardiovascular Disease

The Role of Endomyocardial Biopsy in the Management of Cardiovascular Disease

Relationship Between Results of Pathological Evaluation of Endomyocardial Biopsy and Echocardiographic Indices in Patients With Non-Ischemic Cardiomyopathy

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