Right ventricular longitudinal strain: a tool for diagnosis and prognosis in light-chain amyloidosis

Abstract

FWRVLS should be considered in the diagnostic and prognostic workup in light-chain amyloidosis.

Echocardiographic markers of cardiac amyloidosis in patients with heart failure and left ventricular hypertrophy

“…The present study revealed that a greater LV wall thickness and smaller LV cavity size (measured by both diameter and telediastolic volume) may help to discriminate CA patients from patients with HF and LVH. This data is consistent with results in Uzan et al [6], although in their study controls are formed by patients with LVH without HF. Also, Boldrini et al [21], in a recent article included the LV wall thickness in a diagnostic score of CA in patients with LVH and confirm the diagnostic value of the wall thickness and the LV mass in these patients.…”

Prognostic Value of Right Ventricular Dysfunction in Patients With AL Amyloidosis: Comparison of Different Techniques by Cardiac Magnetic Resonance

“…Another echocardiographic study including 105 patients each with AL amyloidosis, hypertrophic cardiomyopathy, and arterial hypertension was conducted to evaluate the diagnostic and prognostic effects of RV function. In that study, the FWS helped distinguish patients with AL amyloidosis from other patients with left ventricular hypertrophy and was also the only independent predictor of mortality after adjustment for Mayo stage and global left ventricular longitudinal strain 9 . Our study showed that all RV systolic function parameters (RVEF, TAPSE, RVFAC, RVLAS, RVGLS, and RVFWS) were significantly associated with prognosis.…”

“…In that study, the FWS helped distinguish patients with AL amyloidosis from other patients with left ventricular hypertrophy and was also the only independent predictor of mortality after adjustment for Mayo stage and global left ventricular longitudinal strain. 9 Our study showed that all RV systolic function parameters (RVEF, TAPSE, RVFAC, RVLAS, RVGLS, and RVFWS) were significantly associated with prognosis. This suggests that RV systolic dysfunction is a marker of poor prognosis and that RV assessment should be part of the comprehensive evaluation in patients with AL amyloidosis.…”

“…With the deposition of amyloid protein in the heart, cardiac function is impaired, and most outcome studies performed have focused on left ventricular (LV) function 6 . Right ventricular (RV) function plays an important role in risk stratification in cardiac amyloidosis，previous studies have demonstrated that tricuspid annular plane systolic excursion (TAPSE) <17 mm, 7 RV global longitudinal strain (GLS) ≥−17%, 8 and RV free wall longitudinal strain (FWS) ≥−16.5% 9 are associated with worse outcomes. Considering the complex shape and systolic motion, various methods have been used to evaluate RV function, 10 and cardiac magnetic resonance imaging (MRI) is considered the reference standard to quantify RV dimensions and systolic function.…”

Amyloidoza łańcuchów lekkich immunoglobulin z punktu widzenia kardiologa

“…Parametry te mają znaczenie rokownicze w amyloidozie AL [28]. Odkształcenie podłużne wolnej ściany prawej komory okazało się jedynym echokardiograficznym predyktorem śmiertelności całkowitej w amyloidozie AL [29]. Wraz z progresją choroby obserwuje się poszerzanie się jamy prawej komory i narastanie niedomykalności trójdzielnej [30].…”