Right ventricular mechanical dispersion is related to malignant arrhythmias: a study of patients with arrhythmogenic right ventricular cardiomyopathy and subclinical right ventricular dysfunction

Abstract

Right ventricular mechanical dispersion was pronounced in patients with ARVC with VT/VF. Right ventricular mechanical dispersion was present in asymptomatic mutation carriers and may be helpful in risk stratification. Right ventricular and LV function correlated in ARVC patients implying that ARVC is a biventricular disease.

Current and future role of echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy

“…They also found this effect in asymptomatic ARVD/C mutation carriers not fulfilling 2010 TFC, indicating early diagnostic value of mechanical dyssynchrony. Increased mechanical dispersion, probably due to the close correlation with electrical dyssynchrony, was also correlated with the occurrence of ventricular arrhythmias in ARVD/C patients [21].…”

“…The high temporal resolution of echocardiography makes deformation imaging a suitable tool for measuring mechanical dyssynchrony. Measurements of dyssynchrony could provide evidence of early, subtle electrical disturbances in ARVD/C, and may further improve the diagnostic value of echocardiography [21,58]. Moreover, due to the close relationship with electrical dyssynchrony, or electrical activation delay, mechanical dyssynchrony also contains possible prognostic information in predicting future arrhythmic events [21].…”

“…Tops et al [58] showed marked delay in timing of septal and RV free wall peak velocity in ARVD/C compared to controls, indicating RV mechanical delay. Regional time to systolic peak data was analyzed by Sarvari et al [21] and showed that dispersion of time to peak systolic value within the RV was markedly increased in ARVD/C patients compared to controls. They also found this effect in asymptomatic ARVD/C mutation carriers not fulfilling 2010 TFC, indicating early diagnostic value of mechanical dyssynchrony.…”

“…3D imaging enables more accurate RV volumetric measurements compared to conventional echocardiography [19,20]. Regional deformation imaging, another relatively new technique, quantifies regional RV wall motion and provides timing of regional motion [18,21].…”

New echocardiographic insights in short QT syndrome: More than a channelopathy?

“…5,6 Dispersion of repolarization, 22 detected as mechanical dispersion by TDI or STE, has been recently proposed as the substrate of arrhythmias in patients with myocardial infarction, 23 arrhythmogenic right ventricular cardiomyopathy, 24 and long QT syndrome. 7,8 In the context of SQTS, dispersion of repolarization could facilitate the occurrence and maintenance of ventricular (and atrial) fibrillation by fragmentation of wavefronts and wavelet formation secondary to functional tissue heterogeneity.…”