Right Ventricular Structure and Function Are Associated With Incident Atrial Fibrillation

Chatterjee, Neal A.; Shah, Ravi; Murthy, Venkatesh L.; Praestgaard, Amy; Shah, Sanjiv J.; Ventetuolo, Corey E.; Barr, R. Graham; Kronmal, Richard A.; Lima, João A.C.; Bluemke, David A.; Jerosch‐Herold, Michael; Alonso, Álvaro; Kawut, Steven M.

doi:10.1161/circep.116.004738

Cited by 18 publications

(12 citation statements)

References 51 publications

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“…Additionally, we adjusted for LA, left ventricular (LV), and RV variables as obtained from and described in previous studies in MESA [5,7,21]. In brief, the LA variables most closely associated with incident AF were: elevated LA maximum volume index (adjusted HR 1.38, p = 0.04), passive LA EF (adjusted HR 0.55, p < 0.001), and peak LA strain (adjusted HR = 0.68, p = 0.031).…”

Section: Covariatesmentioning

confidence: 99%

“…We additionally created models adjusting for demographics, traditional risk factors, and RV variables previously identified as being associated with incident AF [7] (Additional file 2). RAVI max was significant in fully adjusted models including RV EF and mass (HR per SD:…”

Section: Association Of Ra Parameters and Incident Afmentioning

confidence: 99%

“…Left atrial (LA) functional and structural parameters have been found to be associated with the risk of AF development and are suspected to be either causative or intermediaries in the pathophysiology of AF. Right ventricle (RV) morphology, emptying fraction, and mass, have also been shown to be associated with risk of AF, possibly as biomarkers of pulmonary dysfunction and hypertension [7]. In contrast, the impact of right atrial (RA) structural abnormalities on risk of AF in patients with subclinical heart disease has been less studied.…”

Section: Introductionmentioning

confidence: 99%

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Association of right atrial structure with incident atrial fibrillation: a longitudinal cohort cardiovascular magnetic resonance study from the Multi-Ethnic Study of Atherosclerosis (MESA)

Xie

Yu²,

Ambale-Venkatesh

et al. 2020

Journal of Cardiovascular Magnetic Resonance

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Background: While studies of the left atrium (LA) have demonstrated associations between volumes and emptying fraction with atrial fibrillation (AF), the contribution of right atrial (RA) abnormalities to incident AF remains poorly understood. Objectives: Assess the association between RA structure and function with incident AF using feature-tracking cardiovascular magnetic resonance (CMR). Methods: This is a prospective cohort study of all participants in the Multi-Ethnic Study of Atherosclerosis with baseline CMR, sinus rhythm, and free of clinical cardiovascular disease at study initiation. RA volume, strain, and emptying fraction in participants with incident AF (n = 368) were compared against AF-free (n = 2779). Cox proportional-hazards models assessed association between variables. Results: Participants were aged 60 ± 10 yrs., 55% female, and followed an average 11.2 years. Individuals developing AF had higher baseline RA maximum volume index (mean ± standard deviation [SD]: 24 ± 9 vs 22 ± 8 mL/m 2 , p = 0.002) and minimum volume index (13 ± 7 vs 12 ± 6 mL/m 2 , p < 0.001), and lower baseline RA emptying fraction (45 ± 15% vs 47 ± 15%, p = 0.02), peak global strain (34 ± 17% vs 36 ± 19%, p < 0.001), and peak free-wall strain (40 ± 23% vs 42 ± 26%, p = 0.049) compared with the AF-free population. After adjusting for traditional cardiovascular risk factors and LA volume and function, we found RA maximum volume index (hazards ratio [HR]: 1.13 per SD, p = 0.041) and minimum volume index (HR: 1.12 per SD, p = 0.037) were independently associated with incident AF. Conclusions: In a large multiethnic population, higher RA volume indices were independently associated with incident AF after adjustment for conventional cardiovascular risk factors and LA parameters. It is unclear if this predictive value persists when additional adjustment is made for ventricular parameters.

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Section: Covariatesmentioning

confidence: 99%

Section: Association Of Ra Parameters and Incident Afmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of right atrial structure with incident atrial fibrillation: a longitudinal cohort cardiovascular magnetic resonance study from the Multi-Ethnic Study of Atherosclerosis (MESA)

Xie

Yu²,

Ambale-Venkatesh

et al. 2020

Journal of Cardiovascular Magnetic Resonance

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“…AF, coincidentally with diastolic dysfunction or not, may cause structural right heart change through electrical remodeling. 25 TR with postcapillary pulmonary hypertension due to diastolic dysfunction and elevated LV end-diastolic pressure was the dominant form in the present study. Thus, in the present study, a substantial proportion of patients had isolated secondary (functional) TR.…”

Section: Discussionmentioning

confidence: 50%

Isolated Tricuspid Regurgitation and Long-Term Outcome in Patients With Preserved Ejection Fraction

et al. 2019

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in 2013 at the physician's discretion. 7-10 Subject selection is shown in Figure 1. We excluded patients with severe or moderate aortic stenosis (n=133), aortic regurgitation (n=133), mitral stenosis (n=9), mitral regurgitation (n=169), severe congenital heart disease or pericardial disease (n=0), or LVEF <50% (n=407) due to the effects of these conditions on TR. The study population consisted of 3,714 patients, who were categorized into 2 groups depending on the presence or absence of moderate to severe TR (Figure 1): the moderate to severe TR group (n=53) and the no moderate to severe TR group (n=3,661). The research protocol was approved by the Institutional Review Board of Kitano Hospital (approval number: P16-02-005). Informed consent was waived due to the retrospective design of the study. We disclosed the details of the present study to the public as an opt-out method and the notice clearly informed patients of their right to refuse enrollment. The study protocol conformed to the ethical guidelines of the 1975 Declaration of Helsinki, as reflected in a priori approval by the institution's Human Research Committee. Patient records and information were anonymized and de-identified before analysis. 7-10

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“…In addition, is highly expressed in human stem cell-derived cardio myoblasts and it has been reported as a one of the major atrial fibrillation (AF) susceptibility-conferring genes and an important regulatory factor which modifies circadian function ( 48 – 51 ). Indeed, several studies have reported ventricular enlargement associated with AF and other related cardiovascular phenotypes ( 52 – 54 ). This is in agreement with some other studies consistently suggesting that ventricular dysfunction and AF reduce cerebral blood flow exerting negative influences on cognitive function along in the aging process ( 55 , 56 ).…”

Section: Discussionmentioning

confidence: 99%

Aging-Dependent Genetic Effects Associated to ADHD Predict Longitudinal Changes of Ventricular Volumes in Adulthood

et al. 2020

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Background: Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood-onset disorder that can persist into adult life. Most genetic studies have focused on investigating biological mechanisms of ADHD during childhood. However, little is known about whether genetic variants associated with ADHD influence structural brain changes throughout adulthood. Methods: Participant of the study were drawn from a population-based sample of 3,220 healthy individuals drawn from the Rotterdam Study, with at least two magnetic resonance imaging (MRI)-scans (8,468 scans) obtained every 3-4 years. We investigate associations of genetic single nucleotide polymorphisms (SNPs) that have previously been identified in genome-wide association studies for ADHD, and trajectories of global and subcortical brain structures in an adult population (aged 50 years and older), acquired through MRI. We also evaluated the existence of age-dependent effects of these genetic variants on trajectories of brain structures. These analyses were reproduced among individuals 70 years of age or older to further explore aging-dependent mechanisms. We additionally tested baseline associations using the first MRI-scan of the 3,220 individuals. Results: We observed significant age-dependent effects on the rs212178 in trajectories of ventricular size (lateral ventricles, P= 4E-05; inferior lateral ventricles, P=3.8E-03; third ventricle, P=2.5E-03; fourth ventricle, P=5.5E-03). Specifically, carriers of the G allele, which was reported as protective for ADHD, had a smaller increase of ventricular size compared with homozygotes for the A allele in elder stages. Post hoc analysis on the subset of individuals older than 70 years of age reinforced these results (lateral ventricles, P=7.3E-05). In addition, the rs4916723, and the rs281324 displayed nominal significant age-dependent effects in trajectories of the amygdala volume (P=1.4E-03), and caudate volume (P=1.8E-03), respectively.

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Right Ventricular Structure and Function Are Associated With Incident Atrial Fibrillation

Cited by 18 publications

References 51 publications

Association of right atrial structure with incident atrial fibrillation: a longitudinal cohort cardiovascular magnetic resonance study from the Multi-Ethnic Study of Atherosclerosis (MESA)

Association of right atrial structure with incident atrial fibrillation: a longitudinal cohort cardiovascular magnetic resonance study from the Multi-Ethnic Study of Atherosclerosis (MESA)

Isolated Tricuspid Regurgitation and Long-Term Outcome in Patients With Preserved Ejection Fraction

Aging-Dependent Genetic Effects Associated to ADHD Predict Longitudinal Changes of Ventricular Volumes in Adulthood

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