Right ventricular systolic to diastolic duration ratio: A novel predictor of outcome in adult idiopathic pulmonary arterial hypertension

McCabe, Colm; Vranešić, Irena Ivanac; Verdes, Mireya Castro; Kempny, Aleksander; Khan, Uzair Ali; Price, Laura; Dimopoulos, Konstantinos; Wort, Stephen J.; Li, W.

doi:10.1016/j.ijcard.2019.05.019

Cited by 12 publications

(10 citation statements)

References 20 publications

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“…The S/D can be used to reflect global RV performance in PAH. 19 Our study indicates that the D/S is an independent risk factor for CHF phenotypes and can also be used to aid in the classification of HF phenotypes. This observation is in agreement with previous studies 19 , 20 , 26 , 27 indicating that the S/D can reflect global RV dysfunction, of which the correlates in HFrEF were different from those in HFpEF and HFmrEF.…”

Section: Discussionmentioning

confidence: 69%

“…Since the monitoring of systolic and diastolic durations can reflect cardiac haemodynamics, 18 there is also accumulating evidence that systole and diastole are fundamental to the coronary flow reserve because the functional systolic and diastolic reserves are decreased, even in the early subclinical stages of cardiac dysfunction. 19 , 20 Nevertheless, the durations of systole and diastole are not routinely evaluated for different CHF subtypes. In this study, our results revealed that the D/S was different among HFpEF, HFmrEF and HFrEF and confirmed that a reduced D/S was associated with a worse LVEF and worse systolic function.…”

Section: Discussionmentioning

confidence: 99%

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Study of the Correlation Between the Ratio of Diastolic to Systolic Durations and Echocardiography Measurements and Its Application to the Classification of Heart Failure Phenotypes

Liu¹,

Liao²,

Wang³

et al. 2021

IJGM

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Background This study aimed to investigate the correlation between the ratio of diastolic to systolic durations (D/S) and echocardiographic parameters of patients with chronic heart failure (CHF) and evaluate whether the D/S can be used as a supplementary biomarker for the classification of heart failure (HF) phenotypes. Methods In total, 122 CHF patients with a left ventricular ejection fraction (LVEF) <40%, 40%≤LVEF<50%, or ≥50% were categorized as having HF with a reduced ejection fraction (HFrEF) (N=32), HF with a mid-range ejection fraction (HFmrEF) (N=21) or HF with a preserved ejection fraction (HFpEF) (N=69), respectively. All patients underwent echocardiography for assessment of nineteen structural and functional echocardiographic parameters and digital phonocardiography for the measurement of D/S. Spearman correlation was used to analyse the associations between the D/S and echocardiographic parameters. Multivariate logistic regression analysis was performed to examine the associations between the D/S and HF phenotypes, and receiver operating characteristic (ROC) curve analysis was employed to evaluate the predictive value of the D/S in the classification of HF phenotypes. Results The D/S values of patients with HFrEF, HFmrEF and HFpEF were 1.32±0.06, 1.44±0.11 and 1.54±0.08, respectively, which were significantly different (All P<0.05). A close correlation between the D/S and LVEF was found (r=0.777, P<0.001). The multivariate analysis indicated that the D/S was an independent risk factor for CHF phenotypes (OR=4.927, 95% CI 2.532–9.587; P<0.001). The area under the ROC curve for distinguishing between HFmrEF and HFpEF using the D/S was 0.764 (95% CI 0.707–0.845; P < 0.001) and that for distinguishing between HFmrEF and HFrEF using the D/S was 0.821 (95% CI 0.755–0.882; P < 0.001). Conclusion The D/S was significantly associated with LVEF, and as LVEF decreased, the D/S tended to decrease, which could also serve as a noninvasive supplementary indicator for detecting systolic and diastolic dysfunction.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Study of the Correlation Between the Ratio of Diastolic to Systolic Durations and Echocardiography Measurements and Its Application to the Classification of Heart Failure Phenotypes

Liu¹,

Liao²,

Wang³

et al. 2021

IJGM

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“…The duration of the TR flow reflects S, D duration is measured from the end of the TR flow signal to the new onset of TR in the next cardiac cycle (Figure 7). Thus, compared to healthy controls S/D ratio (usually <1) is prolonged in individuals with PH (42,43). An abnormal S/D ratio can be a surrogate for RV dysfunction.…”

Section: Systolic-to-diastolic Duration Ratiomentioning

confidence: 99%

A guide to echocardiographic assessment in children and adolescents with pulmonary hypertension

Lammers¹,

Apitz²,

Michel‐Behnke³

et al. 2021

Cardiovasc Diagn Ther

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Data from the TOPP registry suggested the potential combination of simple diagnostic non-invasive tests (chest X-ray, electrocardiography and echocardiography) to rule out the presence of PH. In fact, none of the 456 children with PH at the time of enrollment had all three tests considered normal (3).Echocardiography not only reveals the underlying cardiac morphology and diagnosis of any associated

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“…The S/D duration ratio is independent of heart size, making this parameter useful in growing children. The S/D duration ratio, however, is dependent on a clearly defined onset and ending of TR Doppler tracings, so that Doppler derivation could be more reproducible (57).…”

Section: Systolic-to-diastolic Duration Ratiomentioning

confidence: 99%

Update on noninvasive imaging of right ventricle dysfunction in pulmonary hypertension

Truong

Meinel

Haddad

et al. 2020

Cardiovasc Diagn Ther

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Pulmonary hypertension (PH) is a progressive disease affecting patients across the life span.The pathophysiology primarily involves the pulmonary vasculature and right ventricle (RV), but eventually affects the left ventricular (LV) function as well. Safe, accurate imaging modalities are critical for diagnosis, serial monitoring, and tailored therapy. While cardiac catheterization remains the conventional modality for establishing diagnosis and serial monitoring, noninvasive imaging has gained considerable momentum in providing accurate assessment of the entire RV-pulmonary axis. In this state-of-the-art review, we will discuss the most recent developments in echocardiography, magnetic resonance imaging, and computed tomography in PH evaluation from pediatric to adult population.

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Right ventricular systolic to diastolic duration ratio: A novel predictor of outcome in adult idiopathic pulmonary arterial hypertension

Cited by 12 publications

References 20 publications

Study of the Correlation Between the Ratio of Diastolic to Systolic Durations and Echocardiography Measurements and Its Application to the Classification of Heart Failure Phenotypes

Study of the Correlation Between the Ratio of Diastolic to Systolic Durations and Echocardiography Measurements and Its Application to the Classification of Heart Failure Phenotypes

A guide to echocardiographic assessment in children and adolescents with pulmonary hypertension

Update on noninvasive imaging of right ventricle dysfunction in pulmonary hypertension

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