Rigid Nylon Foil-Anchored Polytetrafluoroetyhlene (Gore-Tex) Sheet Stenting for Conjunctival Fornix Reconstruction

Demirci, Hakan; Elner, Susan G.; Elner, Victor M.

doi:10.1016/j.ophtha.2010.01.061

Cited by 14 publications

(4 citation statements)

References 32 publications

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“…The general principle of socket reconstructive techniques is excision of the conjunctival scarred tissues, followed by graft or flap placement to replace lost conjunctiva and enlarge the forniceal space [ 2 ]. Several grafts are mentioned in the literature, including oral mucosa, [ 2 , 3 , 7 ] hard palate, [ 6 , 8 ] skin graft, [ 9 , 10 ] dermis fat graft, [ 11 ] and polytetrafluoroethylene [ 12 , 13 ]. Previous studies have reported that using a full-thickness mucous membrane graft, which allows the grafted tissue to match the conjunctiva histologically, is successful in almost all degrees of contractions [ 3 , 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

Factors affecting anophthalmic socket reconstruction outcomes using autologous oral mucosal graft

Aryasit,

Panyavisitkul,

Damthongsuk

et al. 2024

BMC Ophthalmol

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Background Limited studies have reported surgical outcomes that are defined by strict criteria following grade 2 or 3 socket reconstruction using an oral mucosal graft (OMG). We aimed to determine factors influencing surgical outcomes of anophthalmic socket reconstruction using OMG in patients with grade 2 or 3 socket contractures. Methods Thirty-seven patients who underwent socket reconstruction with autologous OMG between January 2007 and December 2017 were retrospectively analyzed. The successful outcome was defined as an eye prosthesis wearing without experiencing displacement and the absence of any re-operations or additional surgeries following socket reconstruction. Factors affecting surgical outcomes were identified using multivariate analysis. Results A total of 15 male and 22 female patients (mean age: 40.2 ± 17.2 years) were included. The median duration of socket contracture was 21.5 years. Grade 2 and 3 socket contractures, based on Tawfik’s classification, were reported in 20 and 17 patients, respectively. Twenty-eight and eight patients underwent socket reconstruction using OMG alone and OMG combined with a hard palate graft, respectively. The success rates of grades 2 and 3 socket contracture reconstruction were 80.0% and 52.9%, respectively. Multivariate analysis demonstrated that only grade 3 contractures were predictive of worse outcomes. At the final visit (mean follow-up: 6.3 years), 34 patients (91.9%) could wear their eye prostheses. Conclusions Socket reconstruction using autologous OMG can provide acceptable results in grade 2 and 3 contractures; however, satisfactory results were more significantly reported in grade 2 than in grade 3 contractures.

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Section: Discussionmentioning

confidence: 99%

Factors affecting anophthalmic socket reconstruction outcomes using autologous oral mucosal graft

Aryasit,

Panyavisitkul,

Damthongsuk

et al. 2024

BMC Ophthalmol

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“…Expended polytetrafluoroethylene (e-PTFE) is a high polymer material for medical use, and due to its characteristics of inertia, microporous structure and corrosion resistance[ 1 ], it has broad applications in biomedical engineering. For example, the membrane tube implant made of e-PTFE membrane and silicone tube can be used to treat refractory glaucoma[ 2 ]; the covered stent covered by e-PTFE cab effectively alleviate the refractory ascites of liver cirrhosis patients[ 3 ]; the e-PTFE flake stent anchored with rigid nylon foil can be used in the reconstruction of fornical conjunctiva[ 4 ]; the e-PTFE soft tissue patch and vascularized flap can be used in the chest wall reconstruction of patients who had chest wall resection[ 5 ]. With more clinical applications, e-PTFE has gradually replaced the traditional silicone rubber and become one of the most ideal biological tissue substitutes.…”

Section: Introductionmentioning

confidence: 99%

IL-4 modified expanded polytetrafluoroethylene (e-PTFE) surgical patch promotes angiogenesis in transplanted flap and inhibits inflammatory response

Song

Liu

et al. 2023

BMC Surg

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Skin flap transplantation is one of the most common tissue transplantation methods for wound repair and organ reconstruction in plastic surgery. During the transplantation process, the inflammatory response of transplanted flap and angiogenesis are critical to the successful rate of skin flap transplantation. In recent years, to improve the biocompatibility and cell affinity of biomedical materials, the modified biomaterials have gradually become a popular subject in scientific researches. In our study, the IL-4 modified expanded polytetrafluoroethylene (e-PTFE) surgical patch IL4-e-PTFE was prepared, and the rat skin flap transplantation model was constructed. The results of cell experiment prove that IL-4 has potentiation in the angiogenesis of human umbilical vein endothelial cell (HUVEC) induced by monocyte, and IL-4 can also promote angiogenesis by inducing the M2 macrophages. According to the results of in vivo experiment, the apoptosis level of transplanted flap cells of rats in the IL4-e-PTFE group was lower than that in the e-PTFE group, and in the IL4-e-PTFE group, the expression levels of pro-inflammatory cytokines IL-1β, IL-6 and TNF-α showed significantly decline compared to the e-PTFE group, while the expression levels of anti-inflammatory cytokines IL-1Ra, IL-10 and TGF-β presented significant increase compared to the e-PTFE group; the immunofluorescence staining results show that the number of M2 macrophages in transplanted flap area of rats in the IL4-e-PTFE group was significantly higher than that in the e-PTFE group, and the angiogenesis level was remarkably improved. In this study, by preparing IL4-e-PTFE and carrying out the cell and in vivo experiments, a reference method is proposed, which can reduce the inflammatory response during skin transplantation process using e-PTFE and optimize the long-term effects of flap blood vessels, hoping to provide a broader space for the applications of e-PTFE in medicine.

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“…However, even after careful and meticulous surgical manipulations, repeated socket contraction can occur. 8 Mitomycin-C (MMC) is an alkylating antimetabolite agent which acts by inhibiting DNA synthesis with significant ability to suppress fibroblasts proliferation and activity, thus causing a significant reduction of scarring in vitro and in vivo. MMC has been used successfully in glaucoma surgery to prevent recurrence by inhibiting subconjunctival fibrosis.…”

Section: Introductionmentioning

confidence: 99%

“…However, even after careful and meticulous surgical manipulations, repeated socket contraction can occur. 8 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of Topical Mitomycin-C Eye Drops After Reconstructive Surgery for Anophthalmic Contracted Socket

Mattout¹,

Fouda²,

Al-Nashar‎³

2021

OPTH

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Purpose: To report the outcomes of using topical mitomycin-C (MMC) after reconstructive surgery for contracted socket and to compare the results with those of the conventional postoperative treatment. Patients and Methods:The medical records of patients who underwent reconstructive surgery for contracted anophthalmic socket were retrospectively reviewed. Based on the postoperative treatment protocol, two groups of patients were identified; group I (15 patients) who received topical MMC drops (0.02%) 4 times daily for 6 weeks and group II (15 patients) who received the conventional treatment (topical antibiotic-steroid combination). Preoperative data were extracted for age, gender, cause and timing of anophthalmia, history of previous surgeries, preoperative forniceal depth and socket volume (SV). The main postoperative outcome measures were superior fornix depth (SFD), inferior fornix depth (IFD) and SV at the end of 6th postoperative month. Prosthesis fitting and complications were also considered for analysis. Results: The mean preoperative IFD was 1.67±0.04 mm in group I and 1.58±0.37 mm in group II, by the end of the 6th postoperative month it increased to 6.1 ±0.27 mm and 5.12 ±0.25mm, respectively. The mean preoperative SFD in group I was 8.3±0.9 mm and 8.9 ±1.1 mm in group II, by the end of the 6th postoperative month SFD became 13.4±1.2 mm and 10.2±1.4 mm in groups I and II, respectively. The mean SV measured six months postoperatively was 1.9±0.2 mL and 1.3±0.09 mL in groups I and II, respectively. These differences in the postoperative SFD, IFD and SV between both groups were statistically significant. More cases reported successful fitting in group I than in group II but this difference was not statistically significant. Conclusion: Postoperative use of topical MMC is associated with higher forniceal depth and greater SV when compared to the conventional treatment in socket reconstructive surgeries with amniotic membrane graft (AMG).

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Rigid Nylon Foil-Anchored Polytetrafluoroetyhlene (Gore-Tex) Sheet Stenting for Conjunctival Fornix Reconstruction

Cited by 14 publications

References 32 publications

Factors affecting anophthalmic socket reconstruction outcomes using autologous oral mucosal graft

Factors affecting anophthalmic socket reconstruction outcomes using autologous oral mucosal graft

IL-4 modified expanded polytetrafluoroethylene (e-PTFE) surgical patch promotes angiogenesis in transplanted flap and inhibits inflammatory response

Evaluation of Topical Mitomycin-C Eye Drops After Reconstructive Surgery for Anophthalmic Contracted Socket

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