Rim versus sagittal mandibulectomy for the treatment of squamous cell carcinoma: Two types of mandibular preservation

Muñoz-Guerra, M.F.; Campo, Francisco José Rodríguez; Gı́as, Luis Naval; Pérez, José Pedro López

doi:10.1002/hed.10316

Cited by 39 publications

(22 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most clinicians choose surgery as the primary therapy, with postoperative radiation or chemoradiation depending on the tumour extent and stage. When the maxilla or mandible is involved, marginal or segmental resection is needed and the primary aim of resection is to obtain clear surgical margins [77]. However, these resections may cause decreased function and cosmetic deformity.…”

Section: Discussionmentioning

confidence: 99%

Potential molecular targets for inhibiting bone invasion by oral squamous cell carcinoma: a review of mechanisms

Quan

Johnson

Zhou

et al. 2011

Cancer Metastasis Rev

View full text Add to dashboard Cite

Bone invasion is a common characteristic of oral squamous cell carcinoma (OSCC), with adverse affects on patient functionality and survival. Recent studies suggest that it is osteoclasts, rather than malignant keratinocytes themselves, which play the major role in facilitating the entry of the tumour into bone, and its progression within bone. Osteoclasts respond to a variety of local signalling pathways, initiated by products of the malignant epithelial cells. In the present review, we firstly introduce the clinical patterns of bone invasion, and then summarise these signalling pathways and their diverse roles in sequential phases of bone invasion. We also review current researches regarding the incidence and mechanisms of distant metastases to bone, and explain briefly the concept of epithelial-mesenchymal transition, which may generate cancer stem cells and initiate the bone invasion. Finally, we discuss more briefly approaches to the diagnosis and management of OSCC patients with bone invasion. With all these studies and some recent discoveries in our own laboratory, an enhanced understanding of bone invasion will be achieved, which should indicate potential molecular targets for future biotherapies.

show abstract

Section: Discussionmentioning

confidence: 99%

Potential molecular targets for inhibiting bone invasion by oral squamous cell carcinoma: a review of mechanisms

Quan

Johnson

Zhou

et al. 2011

Cancer Metastasis Rev

View full text Add to dashboard Cite

show abstract

“…Marginal mandibular resection seems to be biomechanically sound while maintaining mandibular continuity. Analysis of Guerra et al (2003) disclosed that marginal mandibulectomy is effective in the control of squamous cell carcinoma that is close to or involving the mandible. Mandibular conservation surgery was proven oncologically safe for patients with early mandibular invasion (Werning et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Influence of marginal and segmental mandibular resection on the survival rate in patients with squamous cell carcinoma of the inferior parts of the oral cavity

Wolff

Haßfeld

Hofele

2004

Journal of Cranio-Maxillofacial Surgery

View full text Add to dashboard Cite

“…These anatomic changes can cause significant pain in the temporomandibular joint, restrict the patient to a soft or liquid diet, and cause catastrophic communication dysfunction. [1][2][3]6 En bloc, composite mandibulectomies are often associated with a large soft-tissue defect. Today, there are several approaches that can provide bony reconstruction of the mandible itself, including cancellous marrow grafts and cranial bone grafts.…”

Section: Discussionmentioning

confidence: 99%

Composite Mandibulectomy: A Novel Animal Model

Sidell¹,

Bezouglaia²,

Tetradis³

et al. 2011

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

Objectives-Segmental mandibular defects can result after the treatment of various pathologic processes, including osteoradionecrosis, tumor resection, or fracture nonunion with sequestration. The variety of etiologies and the frequency of occurrence make the reconstruction of segmental mandibular defects a topic of significant interest. Despite these incentives, a well-established small-animal model of the segmental mandibulectomy, including composite resection, does not exist. The objective of this study is the creation of a reliable animal model that can be used to study the reconstruction of en bloc mandibular defects. Surgical techniques and an array of reconstructive options are described. Study design-Description of an animal model.Setting-Animal laboratory at a quaternary care university medical center.Methods-We present an Animal Research Oversight Committee-approved prospective analysis of survival operations in the rat model. A detailed, stepwise description of surgical technique and relevant intraoperative anatomy is presented. Postoperative management, early pitfalls, surgical complications, and future applications are discussed.Results-A total of 72 operations were performed by a single individual between July and October 2010. Two intraoperative and 9 postoperative complications were recognized. There were 6 orocutaneous fistulas, 2 abscesses, and 1 seroma. There were 4 fatalities, which were attributed to anesthetic complications (2, intraoperative), hematoma formation (1, postoperative), and foreign-body aspiration (1, postoperative).

show abstract

Rim versus sagittal mandibulectomy for the treatment of squamous cell carcinoma: Two types of mandibular preservation

Cited by 39 publications

References 27 publications

Potential molecular targets for inhibiting bone invasion by oral squamous cell carcinoma: a review of mechanisms

Potential molecular targets for inhibiting bone invasion by oral squamous cell carcinoma: a review of mechanisms

Influence of marginal and segmental mandibular resection on the survival rate in patients with squamous cell carcinoma of the inferior parts of the oral cavity

Composite Mandibulectomy: A Novel Animal Model

Contact Info

Product

Resources

About