2024
DOI: 10.4103/ijabmr.ijabmr_403_23
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Ring Finger 43 Hot-spot Frameshift Mutation G659V in Colorectal Cancer Patients: Report from a Tertiary Cancer Care Hospital in North India

Smreti Vasudevan,
Anurag Mehta,
Diksha Karki
et al.

Abstract: Background: The Ring Finger 43 (RNF43) is a tumor suppressor gene that negatively regulates the Wnt/β-catenin signaling. The p.G659fs is a recurrent RNF43 C-terminal truncating variant frequent in colorectal cancer (CRC) patients. We aimed to identify this hotspot variant in CRC patients and assessed the relationship between the mutation, clinical characteristics, and tumor β-catenin localization. Materials and Methods: Formalin-fixed, paraffin-embedded… Show more

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