Ring Finger Protein 11 (RNF11) Modulates Dopamine Release in Drosophila

Champaloux, Eve Privman; Donelson, Nathan C.; Pyakurel, Poojan; Wolin, Danielle; Ostendorf, Leah; Denno, Madelaine; Borman, Ryan; Burke, Christopher J.; Short-Miller, Jonah C.; Yoder, Maria R.; Copeland, Jeffrey M.; Sanyal, Subhabrata; Venton, B. Jill

doi:10.1016/j.neuroscience.2020.10.021

Cited by 3 publications

(3 citation statements)

References 53 publications

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“…It modulates ubiquitin-regulated processes that are involved in transforming growth factor beta (TGF-β), nuclear factor-κB (NF-κB), and epidermal growth factor (EGF) signaling pathways. Privman-Champaloux and coauthors [ 44 ], using a Drosophila model, demonstrated that RNF11 affected both dopamine release and uptake. RNF11 expression decreased in human dopaminergic neurons during PD.…”

Section: New Discoveries In Drosophilamentioning

confidence: 99%

Invertebrate Models Untangle the Mechanism of Neurodegeneration in Parkinson’s Disease

Surguchov

2021

Cells

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Parkinson’s disease (PD) is the second most common neurodegenerative disease, afflicting ~10 million people worldwide. Although several genes linked to PD are currently identified, PD remains primarily an idiopathic disorder. Neuronal protein α-synuclein is a major player in disease progression of both genetic and idiopathic forms of PD. However, it cannot alone explain underlying pathological processes. Recent studies demonstrate that many other risk factors can accelerate or further worsen brain dysfunction in PD patients. Several PD models, including non-mammalian eukaryotic organisms, have been developed to identify and characterize these factors. This review discusses recent findings in three PD model organisms, i.e., yeast, Drosophila, and Caenorhabditis elegans, that opened new mechanisms and identified novel contributors to this disorder. These non-mammalian models share many conserved molecular pathways and cellular processes with humans. New players affecting PD pathogenesis include previously unknown genes/proteins, novel signaling pathways, and low molecular weight substances. These findings might respond to the urgent need to discover novel drug targets for PD treatment and new biomarkers for early diagnostics of this disease. Since the study of neurodegeneration using simple eukaryotic organisms brought a huge amount of information, we include only the most recent or the most important relevant data.

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Section: New Discoveries In Drosophilamentioning

confidence: 99%

Invertebrate Models Untangle the Mechanism of Neurodegeneration in Parkinson’s Disease

Surguchov

2021

Cells

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“…In recent work, we reported that downregulation of PD candidate gene RNF11 is associated with higher optogenetically stimulated dopamine release and faster clearance in fruit fly larvae, which supports a potential protective role for RNF11 in maintaining dopamine signaling in PD pathology. 31 Thus, FSCV provides rapid information about the functionality of dopaminergic neurons and quantitative dopamine dynamics. There are many genetic models of PD that have been made in fruit flies, but they have not been tested to explore their dopamine release.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Moreover, the implanted carbon-fiber microelectrode (CFME) is targeted to specific regions of the fly brain to measure local release dynamics. , The modulatory effect of PD-linked genes such as parkin has not been studied in the dopaminergic system of adult Drosophila . In recent work, we reported that downregulation of PD candidate gene RNF11 is associated with higher optogenetically stimulated dopamine release and faster clearance in fruit fly larvae, which supports a potential protective role for RNF11 in maintaining dopamine signaling in PD pathology . Thus, FSCV provides rapid information about the functionality of dopaminergic neurons and quantitative dopamine dynamics.…”

Section: Introductionmentioning

confidence: 99%

Parkin Knockdown Modulates Dopamine Release in the Central Complex, but Not the Mushroom Body Heel, of Aging Drosophila

Dumitrescu

Copeland

Venton

2022

ACS Chem. Neurosci.

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Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic neurons leading to reduced locomotion. Mutations of parkin gene in Drosophila produce the same phenotypes as vertebrate models, but the effect of parkin knockdown on dopamine release is not known. Here, we report age-dependent, spatial variation of dopamine release in the brain of parkin-RNAi adult Drosophila. Dopamine was repetitively stimulated by local application of acetylcholine and quantified by fast-scan cyclic voltammetry in the central complex or mushroom body heel. In the central complex, the main area controlling locomotor function, dopamine release is maintained for repeated stimulations in aged control flies, but lower concentrations of dopamine are released in the central complex of aged parkin-RNAi flies. In the mushroom body heel, the dopamine release decrease in older parkin-RNAi flies is similar to controls. There is not significant dopaminergic neuronal loss even in older parkin knockdown flies, which indicates that the changes in stimulated dopamine release are due to alterations of neuronal function. In young parkin-RNAi flies, locomotion is inhibited by 30%, while in older parkin-RNAi flies it is inhibited by 85%. Overall, stimulated dopamine release is modulated by parkin in an age and brain region dependent manner. Correlating the functional state of the dopaminergic system with behavioral phenotypes provides unique insights into the PD mechanism. Drosophila can be used to study dopamine functionality in PD, elucidate how genetics influence dopamine, and test potential therapies to maintain dopamine release.

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High expression of ring finger protein 115 contributes to the progression of colorectal cancer via WNT/β-catenin pathway

Zhang

et al. 2022

Mol. Cell. Toxicol.

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Ring Finger Protein 11 (RNF11) Modulates Dopamine Release in Drosophila

Cited by 3 publications

References 53 publications

Invertebrate Models Untangle the Mechanism of Neurodegeneration in Parkinson’s Disease

Invertebrate Models Untangle the Mechanism of Neurodegeneration in Parkinson’s Disease

Parkin Knockdown Modulates Dopamine Release in the Central Complex, but Not the Mushroom Body Heel, of Aging Drosophila

High expression of ring finger protein 115 contributes to the progression of colorectal cancer via WNT/β-catenin pathway

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