Ring-opening Bulk Polymerization of <scp>l</scp>-Lactide in Porous Hydroxyapatite

Sugiyama, Nami; Kunibu, Ryoko; Yoshizawa‐Fujita, Masahiro; Takeoka, Yuko; Aizawa, Mamoru; Rikukawa, Masahiro

doi:10.1246/cl.2007.1476

Cited by 9 publications

(7 citation statements)

References 12 publications

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“…Despite the fact that the polymerization of lactides from various HA materials has been described in previous publications [ 16 , 17 , 18 , 19 , 29 , 30 ], a systematic investigation of the process has not been performed. Thus, the main goal of this study is the detailed exploration of the influence of the polymerization conditions (type of HA, monomer/initiator ratio) on the density of grafting, the length of the grafted fragments and the physical properties of the graft polymers formed.…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite-poly(d,l-lactide) Nanografts. Synthesis and Characterization as Bone Cement Additives

2021

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This paper reports the creation of hydroxyapatite/polyester nanografts by “graft-from” polymerization of d,l-lactide with [Ca5(OH)(PO4)3]2 as the initiator and tin(II)-2-ethylhexanoate as the catalyst. Model polymerizations were performed with cyclooctanol as initiator to confirm the grafting on the surface of the hydroxyapatite nanocrystals. Polymers with the highest molecular mass (Mn) between 4250 Da (cyclooctanol) and 6100 Da (hydroxyapatite) were produced. In both cases the molecular mass distributions of the polymers formed were monomodal. The materials obtained were characterized by size-exclusion chromatography, NMR and FT-IR spectroscopy, and thermal methods. Their suitability as additives for commercial bone cement (Simplex P Speedset, Stryker Orthopaedics) has been confirmed by thermal analysis techniques and mechanical testing. The results obtained show that addition of the hydroxyapatite/ polyester nanografts improved both thermal and mechanical properties of the bone cement.

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Section: Introductionmentioning

confidence: 99%

Hydroxyapatite-poly(d,l-lactide) Nanografts. Synthesis and Characterization as Bone Cement Additives

2021

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“…Such composites show a high degree of biocompatibility, with low levels of undesirable immunological responses and good resorbable properties, and can be formed into a variety of shapes and sizes. HA has been shown to induce ring opening polymerization of cyclic lactones including ε−caprolactone, δ‐valerolactone, and l ‐lactide to produce biologically benign polymers . We recently reported the use of HA derived from mammalian bone to initiate the polymerization of l ‐lactide to poly‐ l ‐lactide (PLLA) .…”

Section: Introductionmentioning

confidence: 99%

“…HA has been shown to induce ring opening polymerization of cyclic lactones including e2caprolactone, d-valerolactone, and L-lactide to produce biologically benign polymers. [4][5][6][7] We recently reported the use of HA derived from mammalian bone to initiate the polymerization of L-lactide to poly-L-lactide (PLLA). 8 Our goal was to remove organic components that might lead to undesired immune responses while producing a composite that more closely mimics the mechanical properties of living bone.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic composites by surface‐initiated polymerization of cyclic lactones at anorganic bone: Preparation and in vitro evaluation of osteoblast and osteoclast competence

Wiegand

Hiebner

Gauza

et al. 2013

J Biomedical Materials Res

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Biomimetic composites were constructed using anorganic bone to initiate the polymerization of cyclic lactones. The resulting anorganic bone/polylactone composites preserve the inorganic structure and the mechanical properties of the original bone. Thermal conditions used to prepare the anorganic bone were shown to control the surface functionalities, surface area, and crystallinity, all of which influence the rates of subsequent polymerizations. Thermal pretreatment of anorganic bone was examined as a function of time and temperature, ranging from 400°C to 800°C. Polymerization rates of different monomers were also compared. Additionally, in vitro evaluations of anorganic bone/poly-L-lactide and anorganic bone/polyglycolide composites for osteoblast and osteoclast competence suggest that these composites are good candidates for potential in vivo use, since both composites promoted osteoblast differentiation. The anorganic bone/poly-L-lactide composite also promoted osteoclast differentiation.

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“…In the literature to date, only the manufacture, mechanical properties and bioactivity of these new interpenetrating polymerceramic composites have been described (Yunos et al 2008). Reported manufacturing methods included in situ polymerization using enzymes (Aizawa et al 2004;Sugiyama et al 2007), microwaves or thermal energy (Pezzotti et al 2002;Jin et al 2006) and vacuum-infiltration of the porous ceramic matrix with the polymer (Miao et al 2005(Miao et al , 2007. The mechanical properties were greatly improved over the unfilled ceramic (Nakahira et al 2002;Pezzotti et al 2002;Zhang & Zhang 2002;Li et al 2003;Sharma & Pezzotti 2003;Miao et al 2005Miao et al , 2007Jin et al 2006;.…”

Section: Introductionmentioning

confidence: 99%

The degradation properties of co-continuous calcium phosphate polyester composites: insights with synchrotron micro-computer tomography

Ehrenfried

Farrar

Cameron

2010

J. R. Soc. Interface.

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This study investigates the in vitro degradation properties of composites consisting of a porous tricalcium phosphate (TCP) foam filled with degradable poly(DL-lactic acid) (PDLLA) via either in situ polymerization or infiltration. The motivation was to develop a material for bone repair that would be initially mechanically strong and would develop porosity during degradation of one of the components. A thorough analysis of the physical in vitro degradation properties has been conducted and reported by the same authors elsewhere. Synchrotron microcomputer tomography analysis (conducted at ID19, ESRF, Grenoble, France) allowed detailed insights to be gained into the process of the composites' degradation, which was discovered to be strongly influenced by the manufacturing method. The polymer phase of in situ-polymerized TCP-PDLLA degraded as a bulk sample, with faster degradation in the centre of the sample as a whole. In contrast, the polymer phase of infiltrated TCP-PDLLA degraded as individual polymer spheres with faster degradation in the centre of each sphere.

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Ring-opening Bulk Polymerization of l-Lactide in Porous Hydroxyapatite

Cited by 9 publications

References 12 publications

Hydroxyapatite-poly(d,l-lactide) Nanografts. Synthesis and Characterization as Bone Cement Additives

Hydroxyapatite-poly(d,l-lactide) Nanografts. Synthesis and Characterization as Bone Cement Additives

Biomimetic composites by surface‐initiated polymerization of cyclic lactones at anorganic bone: Preparation and in vitro evaluation of osteoblast and osteoclast competence

The degradation properties of co-continuous calcium phosphate polyester composites: insights with synchrotron micro-computer tomography

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