Ring opening of cyclopropyl ketones with 1,3-diketones for the synthesis of 1,6-diketone derivatives

Asymmetric ring-opening reactions of donor–acceptor cyclopropanes with 1,3-cyclodiones

“… 4 Recently, we developed scandium triflate catalyzed O-selective nucleophilic ring-opening of D–A cyclopropanes with 1,3-cyclodiones, 5 b where the ring-opening products 1,3-cyclodione enol ether derivatives were obtained in good to excellent yields ( Scheme 1a ). In continuation of our research interests in the reactions between 1,3-dicarbonyl compounds and D–A cyclopropanes, 5 herein, we disclose the asymmetric version of the ring opening reactions of D–A cyclopropanes with 1,3-cyclodiones ( Scheme 1b ).…”