Ring-substituted derivatives of 5,6,11,12-tetrahydrodibenzo[b,f][1,4]-diazocine

Palladium‐Catalyzed Intramolecular Sulfonamidation/Oxidation of Imines: Access to Multifunctional Benzimidazoles

“…N ‐(2‐Amino‐5‐chlorophenyl)‐4‐methylbenzenesulfonamide (d): 10 Yield: 69%. 1 H NMR (400 MHz, CDCl 3 ): δ =2.41 (s, 3 H), 4.21 (s, 2 H), 6.38 (d, J =8.0 Hz, 1 H), 6.45 (d, J =8.0 Hz, 1 H), 6.67 (s, 1 H), 6.69 (d, J =2.0 Hz, 1 H), 7.25 (d, J =9.2 Hz, 2 H), 7.62 (d, J =8.4 Hz, 2 H); MS (ESI): m / z =297.0 [M + ]; IR (KBr): ν =3475, 3382, 3258, 3067, 2921, 1911, 1622, 1498, 1437, 1390, 1334, 1214, 1165, 1090, 887, 854, 812, 722, 700, 672, 560 cm −1 .…”

A study of mono-, di- and tri-tosylated amines: An unexpected sulfonamide

“…158-159 °C (from dichloromethane:light petroleum ether). λ max (EtOH)/nm 240 (log ε 3.8); ν max (diamond)(cm -1 ) 3375w, 1596w, 1492w, 1376s, 1158s, 1084w, 902s, 855w, 810w, 666vs, 546vs, 499w and 487w; δ H (400 MHz; CDCl 3 ) 2.41 (3H, s), 2.50 (6H, s), 6…”

“…210-211 °C (from dichloromethane:light petroleum ether). λ max (EtOH)/nm 320 (log ε 3.0) and 235 (3.8); λ max (diamond)(cm -1 ) 1595w, 1371s, 1349s, 1294s, 1187s, 1159s, 1084s, 1018s, 934s, 809s, 752w, 659s and 539s; δ H (400 MHz; CDCl 3 ) 2.21 (3H, s), 2.40 (6H, s), 6…”

“…1 Ditosylate 4 condenses with α,α′-dibromo-o-xylene 7 and K 2 CO 3 to give an unusual eight-membered ring heterocycle 8 and various derivatives, which were investigated for their biological properties (Scheme 3). 6 Ditosylate 4 condenses with 1,2-dibromopropanol 9 with sodium/EtOH to form the six-membered heterocycle 10 and various derivatives (Scheme 4). 7 Ditosylate 4 condenses with SiCl 4 to form a bis-spirocyclic heterocycle 11, which is bonded around the central silicon atom (Scheme 5).…”

One-Pot Synthesis of 2,3-Dihydro-1H-benzimidazoles

“…2,3-Dihydro-1 H -benzimidazoles can be obtained through condensation of 1,2-disubstituted phenylenediamines 2 with aldehydes or the Mannich reaction with formaldehyde and benzotriazole . Another synthetic methodology is based on reduction of benzimidazolium salts. , …”