Ringing bells: Morganella morganii fights for recognition

Bandy, Altaf

doi:10.1016/j.puhe.2020.01.016

Cited by 28 publications

(28 citation statements)

References 57 publications

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“…While the role of S. infantis and its direct implication in gut diseases remains obscure, the levels of S. infantis are increased in individuals with acute cerebral infarction compared with healthy controls [49]. M. morganii is a rare opportunistic pathogen associated with multiple organ pathogenicity across all age groups [50]. On the other hand, the fecal samples that had low to none SARS-CoV-2 infectivity reported higher abundances of short-chain fatty acid (SCFA)-producing bacteria like Parabacteroides merdae, Bacteroides stercoris, Alistipes onderdonkii and Lachnospiraceae bacterium 1_1_57FAA [43].…”

Section: Covid-19 and Gut Pathogensmentioning

confidence: 99%

Interplay between severities of COVID-19 and the gut microbiome: implications of bacterial co-infections?

2021

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COVID-19 is an acute respiratory distress syndrome and is often accompanied by gastrointestinal symptoms. The SARS-CoV-2 has been traced not only in nasopharyngeal and mid-nasal swabs but also in stool and rectal swabs of COVID-19 patients. The gut microbiota is important for an effective immune response as it ensures that unfavorable immune reactions in lungs and other vital organs are regulated. The human gut-lung microbiota interplay provides a framework for therapies in the treatment and management of several pulmonary diseases and infections. Here, we have collated data from COVID-19 studies, which suggest that bacterial co-infections as well as the gut-lung cross talk may be important players in COVID-19 disease prognosis. Our analyses suggests a role of gut microbiome in pathogen infections as well as in an array of excessive immune reactions during and post COVID-19 infection recovery period.

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Section: Covid-19 and Gut Pathogensmentioning

confidence: 99%

Interplay between severities of COVID-19 and the gut microbiome: implications of bacterial co-infections?

2021

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“…The pathogen was initially found to cause mild summer diarrhea; before the 1990s, there were only scattered case reports of M. morganii -related infections. In recent decades, cases have increasingly been reported, and it was demonstrated that the pathogen can further cause severe nosocomial infections, including sepsis and hepatobiliary, urinary tract, and wound infections [ 4 , 5 , 15 , 16 ]. In a 6-year study in a tertiary hospital, M. morganii ranked as the ninth most common pathogen (1.5%) among all gram-negative nosocomial infections [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Most of the causative pathogens of postoperative endophthalmitis are gram-positive bacteria (45.9–97%), including Staphylococcus aureus and coagulase-negative staphylococci [ 2 , 3 ]. As a gram-negative facultative anaerobic rod, Morganella morganii is associated with multi-drug resistance and high morbidity and mortality, especially in immunocompromised patients and neonates [ 4 , 5 ]. However, M. morganii has rarely been reported as a cause of infectious ocular disease.…”

Section: Introductionmentioning

confidence: 99%

Postvitrectomy endophthalmitis caused by Morganella morganii: a case report and literature review

et al. 2022

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Background Postvitrectomy endophthalmitis is a rare and serious complication following vitreoretinal surgeries. Morganella morganii, an emerging gram-negative, facultative anaerobic rod, is related to severe nosocomial infections in various organs and thus has gained importance in recent decades. Morganella morganii infection following intraocular surgery is rarely reported. Case presentation We report an immunocompetent patient with Morganella morganii-related endophthalmitis after vitrectomy for retinal detachment who presented with hand motion visual acuity, hypopyon and a unique retrolental exudative membrane. Initially, the patient was unresponsive to empirical intravitreal ceftazidime and vancomycin but recovered with vision preservation (20/63) after surgical removal of the membrane and silicone oil tamponade. Conclusions Morganella morganii intraocular infection is often devastating, likely due to its high multidrug-resistance rate via intrinsic ß-lactamase production, multiple acquired traits related to additional genetic mechanisms, and fimbrial adhesion, urease production, and type III secretion system-associated biofilm formation. The above characteristics of M. morganii may lead to an inadequate response to empirical intravitreal antibiotics, and early surgical intervention should be considered.

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“…Apesar de M. morganii ter tido baixa incidência durante o período considerado na coleta de dados, há casos documentados de infecções causadas pelo microrganismo em todo o mundo 12 . Um dos fatores que levaram ao aumento da sua incidência no trato urinário se deve a produção de ureases, enzimas responsáveis por converter ureia em amônia e dióxido de carbono que facilitam o crescimento bacteriano e a formação de biofilme 13 .…”

Section: Discussionunclassified

Perfil De Resistência Bacteriana Em Uroculturas Realizadas Em São Luís – Maranhão

Alves

Barbosa²,

Amaral³

et al. 2021

Saúde (Sta. Maria)

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Objetivo: analisar a prevalência de bactérias isoladas em exames de urina realizados em um laboratório particular da cidade de São Luís – MA.Métodos: realizou-se o levantamento sobre a identificação de bactérias isoladas nos exames de urocultura e no antibiograma através dos documentos fornecidos pelo laboratório, tendo como referência aqueles realizados no período de janeiro de 2018 a junho de 2019. Os dados foram apresentados em forma de tabelas.Resultados: identificou-se um total de 622 microrganismos. Entre os principais gêneros bacterianos encontrados estavam Escherichia coli, Acinetobacter baumannii e Klebsiella pneumoniae. Em relação ao perfil de resistência bacteriana aos antimicrobianos, verificou-se uma maior resistência ao Sulfametoxazol/Trimetoprim em associação, seguido da Tetraciclina, Ampicilina e Levofloxacin.Considerações Finais: os resultados evidenciaram o aparecimento de bactérias resistentes aos antimicrobianos de referência. Recomenda-se a melhoria dos protocolos terapêuticos existentes com o intuito de combater a resistência bacteriana.

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Ringing bells: Morganella morganii fights for recognition

Cited by 28 publications

References 57 publications

Interplay between severities of COVID-19 and the gut microbiome: implications of bacterial co-infections?

Interplay between severities of COVID-19 and the gut microbiome: implications of bacterial co-infections?

Postvitrectomy endophthalmitis caused by Morganella morganii: a case report and literature review

Perfil De Resistência Bacteriana Em Uroculturas Realizadas Em São Luís – Maranhão

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