2011
DOI: 10.1074/jbc.m110.148486
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RioK1, a New Interactor of Protein Arginine Methyltransferase 5 (PRMT5), Competes with pICln for Binding and Modulates PRMT5 Complex Composition and Substrate Specificity

Abstract: Protein arginine methylation plays a critical role in differential gene expression through modulating protein-protein and protein-DNA/RNA interactions. Although numerous proteins undergo arginine methylation, only limited information is available on how protein arginine methyltransferases (PRMTs) identify their substrates. The human PRMT5 complex consists of PRMT5, WD45/MEP50 (WD repeat domain 45/methylosome protein 50), and pICln and catalyzes the symmetrical arginine dimethylation of its substrate proteins. … Show more

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Cited by 135 publications
(149 citation statements)
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“…S1A in the supplemental material, GFP-SpICln is found in the cytoplasm but is more concentrated in the nucleus. Such localization is similar to the subcellular localization of the human ICln, which is also predominantly nuclear (36).…”
Section: Identification Of An S Pombe Icln Orthologsupporting
confidence: 49%
“…S1A in the supplemental material, GFP-SpICln is found in the cytoplasm but is more concentrated in the nucleus. Such localization is similar to the subcellular localization of the human ICln, which is also predominantly nuclear (36).…”
Section: Identification Of An S Pombe Icln Orthologsupporting
confidence: 49%
“…pICLn interacts with the PRMT5 region now known to have a TIM-barrel structure, and it stimulates PRTM5's activity towards Sm proteins (27). Another protein, RioK1 competes with pICLn for binding to PRMT5 and directs PRMT5's activity towards the RNA-binding protein nucleolin (29). Thus, the TIM-barrel domain of PRMT5 also serves as a scaffold for the binding of adaptor proteins, such as pICLn and RioK1.…”
Section: Discussionmentioning
confidence: 99%
“…In turn, these changes could influence the localization, substrate recognition and affinity, and/or activity of PRMT5 (35)(36)(37).…”
Section: Methodsmentioning
confidence: 99%