Rise in Dehydroepiandrosterone and Oestrogens During Clomiphene Administration in Normal Men

Kampmann, Jens P.; Jørgensen, F.; Bennett, E.; Johnsen, Svend G.

doi:10.1530/acta.0.0830166

Cited by 13 publications

(19 citation statements)

References 13 publications

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“…The elevations of the serum concentrations of FSH and LH were significant for the entire Group 1 and in agreement with previous reports (Bardin et al 1967;Heller et al 1969;Kampmann et al 1976). It might therefore be as¬ sumed that corresponding increases in the serum concentrations of testosterone and the urinary excretion of oestrogen derivatives had occurred (Heller et al 1969;Kampmann et al 1976).…”

Section: Discussionsupporting

confidence: 93%

Effect of Clomifene on Thyroid Function in Normal Men

Feldt‐Rasmussen

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et al. 1979

Acta Endocrinologica

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To study the effect on thyroid function 100 mg of clomifene citrate was given once a day to two groups of healthy male volunteers for 5 and 12 consecutive days, respectively. In both groups serum concentrations of TSH, thyroxine, triiodothyronine, T3 resin uptake test and thyroid hormone binding proteins were measured before, during and after oral administration of clomifene. The effect of clomifene treatment was evaluated in Group 1 by means of serum FSH and LH measurements. Further in Group 2 the serum TSH response to iv TRH (200 \g=m\g) was also investigated.The mean per cent elevations in serum concentrations of FSH and LH were 145 and 200, respectively. In Group 1 a small but statistically significant decrease within reference limits in triiodothyronine (P < 0.01) and free thyroxine index (P < 0.02) was found on day 4 of clomifene. On day 5 a slight increase in TSH was observed (P < 0.05). In Group 2 the response of TSH to TRH showed a non-significant increase after 5 days and a significant increase (P < 0.01) after 12 days of clomifene. Eight days after discontinuation of the drug the response was restored to normal. No changes in the thyroid hormone binding proteins in serum could be demonstrated. Though the observed changes were slight, they indicate that clomifene exerts an influence directly on the thyroid function.The biological actions of clomifene citrate has been attributed to its properties as an anti-oestrogen, as it was thought to block oestrogen receptors in the hypo¬ thalamus and in the pituitary (Roy et al. 196ib,c). Furthermore clomifene was known to have a weak oestrogenic effect (Roy et al. 1964«,b).

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Section: Discussionsupporting

confidence: 93%

Effect of Clomifene on Thyroid Function in Normal Men

Feldt‐Rasmussen

Lange

Date

et al. 1979

Acta Endocrinologica

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“…As described previously (Kampmann et al 1976) FSH, LH and testosterone were measured by radioimmunoassay, fractionation of urinary 17-ketosteroids (A, E, D) was performed with gas liquid chromatography and total oestrogens measured by a spectrofluorometric method. No side-effects were recorded from the clomiphene administra¬ tion.…”

Section: Hormone Department Statens Seruminstitut Andmentioning

confidence: 99%

“…But a significant correlation existed between rises of FSH and rises of oestrogens. This confirms that one action of FSH is to stimulate production of testicular oestrogens which presumably takes place in the Sertoli cells.Recently we published that clomiphene besides its well-known stimulatory effect on serum FSH, LH and testosterone (T) increases urinary dehydroepiandroste¬ rone (D) and urinary oestrogens (Oe) in normal men (Kampmann et al 1976).In this paper we have correlated the clomiphene induced rises in the above mentioned hormones plus the urinary androgen metabolites androsterone + aetio¬ cholanolone (A + E). The purpose of the paper has been to elucidate how these hormones are inter-related at physiological levels in men.…”

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confidence: 95%

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Correlation Between Rises of Gonadotrophins and Rises of Sex Steroids During Clomiphene Test in Men

et al. 1977

Acta Endocrinologica

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Serum FSH, LH and testosterone and urinary excretion of androsterone, aetiocholanolone, dehydroepiandrosterone and total oestrogens were measured in normal and oligospermic men before and after clomiphene stimulation. Responses in all parameters were highly variably from one individual to another and this great variation formed the basis for investigating the correlations between responses. There was no correlation between increase of FSH and LH or increase of LH and steroids. Also there was no correlation between rises of FSH and rises of androgens. But a significant correlation existed between rises of FSH and rises of oestrogens. This confirms that one action of FSH is to stimulate production of testicular oestrogens which presumably takes place in the Sertoli cells.Recently we published that clomiphene besides its well-known stimulatory effect on serum FSH, LH and testosterone (T) increases urinary dehydroepiandroste¬ rone (D) and urinary oestrogens (Oe) in normal men (Kampmann et al. 1976).In this paper we have correlated the clomiphene induced rises in the above mentioned hormones plus the urinary androgen metabolites androsterone + aetio¬ cholanolone (A + E). The purpose of the paper has been to elucidate how these hormones are inter-related at physiological levels in men.

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“…Two studies reported a clomiphene-induced increase in plasma DHEA and DHEAS concentrations when administered for 15 days [91,92].…”

Section: Clomiphenementioning

confidence: 99%