Rise in Plasma Triglycerides: An Early Marker of Oxidative Stress in Urban Indians

Abstract

mmol/L) in 34%, high total cholesterol (.5.2 mmol/L) in 29% and high LDL-C (.4.1 mmol/L) in 20% of patients. 89% of dyslipidemic patients were on simvastatin on admission and of those 49% only achieved an LDL-C target less than 2.6 mmol/L. Conclusions: The present study shows a high prevalence of diabetes, hypertension, and dyslipidemia in the Omani population undergoing CABG. The most common pattern of dyslipidemia is low HDL-C. A small percentage of the study group had achieved therapeutic LDL-C targets, which put them at continuous risk of rapid atherosclerotic attrition of coronary bypass grafts.Synopsis: Three generations ago, most physicians learned very little about cholesterol, and many doubted the value of treating elevated values. Six decades of double-blind controlled trials have converted cholesterol into a daily conversation piece, and a standard of care requirement for cardiovascular disease. In a similar manner today, we are faced with a global increase in aging with significant impacts on a large number of associated risk factors and illnesses that threaten to eventually overburden an already stretched healthcare system. Nevertheless, aging per se has not been examined with an appropriately intense investigational effort. Life expectancy is lengthening in every developed nation. Three quarters of babies will live to their 75th birthday, and many will reach 80 plus years. Purpose: The object of this poster is to provide background information to better understand the roles of leptin and cholesterol ester transfer protein (CETP), along with suggestions for future studies and therapeutic approaches. Methods: Literature review and an examination of present prevailing beliefs. Results: Leptin is an adipokine, a biological mediator, which signals longer-term caloric intake and which facilitates synaptic plasticity in the hippocampus, promotes beta-amyloid clearance and improves memory in animal models of aging. In a prospective study of approximately 200 Framingham subjects (average age 87), after 7 years of leptin assay, greater leptin levels were associated with a lower risk of dementia and Alzheimer disease, as well as a greater total brain volume in asymptomatic adults. CETP regulates high-density lipoprotein metabolism. A genetic variant VV improved the odds of reaching 100 and reduced the risk of developing dementia. Compared with those elderly subjects lacking this gene variant, those with the gene were twice as likely to have good cognition. Subjects reaching 100 years of age were three times more likely to possess the VV gene variant of CETP compared with control patients.

Atherogenic index of plasma predicts coronary artery disease severity and major adverse cardiac events in absence of conventional risk factors

“…The incidence of CAD has been rising in India, parallel with changing Indian dietary patterns, which have increasingly been shown to be rich in seed oils comprising ω-6 fatty acids [41]. An elevated ω-6/ω-3 ratio may represent one aspect of the epidemic of CAD in this population, as it causes endothelial dysfunction and induction of proinflammatory cytokines [42,43].…”