Rise of Herbal and Traditional Medicine in Erectile Dysfunction Management

Ho, Chee Kong Christopher; Tan, Hui Meng

doi:10.1007/s11934-011-0217-x

Cited by 68 publications

(49 citation statements)

References 60 publications

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“…20,22,[25][26][27] Because ginseng is not a drug that can treat severe ED, we enrolled mild-to-moderate ED patients only. We found that SKGB group showed improvement after 8 weeks of treatment by within-group analysis.…”

Section: Discussionmentioning

confidence: 99%

Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study

et al. 2012

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Ginseng is beneficial for many aspects of human physiology, including sexual function. In this study, we have evaluated the efficacy and safety of an extract of ginseng berry, which has a ginsenoside profile distinct from other parts of the plant, on sexual function in men with erectile dysfunction. In all, 119 men with mild-to-moderate ED participated in a multicenter, randomized, double-blind, parallel, placebo-controlled clinical study. They were administered 4 tablets of either standardized Korean ginseng berry (SKGB, 350 mg ginseng berry extract per tablet), or placebo, daily, for 8 weeks. Efficacy was assessed with the International Index of Erectile Function (IIEF)-15 and premature ejaculation diagnostic tool (PEDT) at the end of the 4th and 8th week. We observed that the total and each of the individual domain scores of IIEF-15 increased from 40.95 ± 7.05 to 46.19 ± 12.69 significantly in the SKGB by the 8th week (Po0.05). The erectile function domain of IIEF changed slightly from 17.17±2.57 to 18.59±5.99 in the SKGB group by the 8th week (Po0.05). In addition, PEDT scores significantly improved from 9.14 ± 4.57 to 7.97 ± 4.4 and 7.53 ± 4.26 in the SKGB group after 4 and 8 weeks of treatment (Po0.05). Safety markers including hormone and lipid in the blood were assessed at the end of the 4th and 8th week and they remained unchanged. Oral administration of the SKGB extract improved all domains of sexual function. It can be used as an alternative medicine to improve sexual life in men with sexual dysfunction.

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Section: Discussionmentioning

confidence: 99%

Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study

et al. 2012

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“…Although evidencebased sexual drug treatment has increased tremendously over the past two decades, and despite effective well-established treatment options for ED, many patients are still dissatisfied. 17 Dropout rates for current medical therapies are high, and overall satisfaction is below expectation due to drug inefficiency and adverse events such as headache and hot flashes. Further, while ED can generally be treated successfully using current treatment options, it cannot be cured.…”

Section: Pro-erectile Effects Of Ginseng Berry Ks Cho Et Al 505mentioning

confidence: 99%

Effects of Korean ginseng berry extract (GB0710) on penile erection: evidence from in vitro and in vivo studies

Park¹,

Kim²,

Jeon³

et al. 2013

Asian J Androl

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Several reports have promoted the root-derived Korean red ginseng (KRG; Panax ginseng) as alternative treatment for erectile dysfunction (ED), and ginsenosides are known to be the principal active ingredients of ginseng. Recent studies showed that ginseng berries produce more ginsenosides than KRG; thus, we investigated the ability of the Korean ginseng berry extract GB0710 to relax the penile corpus cavernosum smooth muscle (CCSM) in this study. As a comparative control, the results were compared to those obtained using KRG. In addition, possible mechanisms of action for GB0710 were investigated. While KRG and GB0710 both displayed dose-dependent relaxation effects on precontracted rabbit CCSM in vitro, GB0710 was shown to be more potent than KRG. The GB0710-induced relaxation could be partially reduced by removing the endothelium. In addition, pre-treatment with several nitric oxide (NO) inhibitors significantly inhibited the relaxation of muscle strips. Furthermore, administration of GB0710 increased intracavernosal pressure (ICP) in a rat in vivo model in both a dose-and duration-dependent manner. Intracellular NO production in human microvascular endothelial cells could be induced by GB0710 and inhibited by N G -monomethyl-L-arginine. In conclusion, GB0710 had a greater relaxation effect on rabbit CCSM than did KRG extract, and increased ICP in a rat model in both a dose-and a duration-dependent manner. This relaxing effect might be mediated by NO production. Keywords: corpus cavernosum; erectile dysfunction (ED); ginseng berry; nitric oxide (NO); smooth muscle INTRODUCTION Erectile dysfunction (ED) is defined as the inability to attain or maintain penile erection sufficient for satisfactory sexual intercourse. ED is a common condition in middle-aged men that has serious adverse effects on quality of life. It has been reported that approximately 50% of men aged 40-80 years suffer from ED to some degree. 1 One of the etiological causes of ED is the reduced bioavailability of nitric oxide (NO). This causes insufficient relaxation of smooth muscle in the penile corpus cavernosum, leading to a subsequently insufficient inflow of blood. Several extensive studies have investigated the positive effects of ginseng on ED, thereby implicating the NO pathway as the mechanism of action. 2,3 Among these, various reports have promoted the root-derived Korean red gingseng (KRG; Panax ginseng) as alternative treatment for ED, citing the stimulatory effect of KRG on the corpus cavernosum smooth muscle (CCSM) of the penis. [4][5][6] The principal active ingredients of ginseng are ginsenosides (also called ginseng saponins), which are amphiphilic molecules comprised of an aglycon backbone (a hydrophobic four-ring steroid-like structure) linked to hydrophilic carbohydrate side chains that consist of monomers, dimers and tetramers. 5,7 Ginsenoside is widely and variably distributed thoughout the ginseng plant. 8 Kim et al. 9 investigated the ginsenoside content of Korean ginseng, indicating ginseng berries (GB) and ginseng r...

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“…Though herbal medicines are not a prescribed option of choice for patients in the United States, in other parts of the world like Asia, Africa and the Middle East, it is a widely used form of therapy for men with ED [44]. However, although there are a myriad of herbal treatments that are very appealing for patients with ED, caution must be warranted, since some herbal medicines may cause deleterious drug interactions, especially in men with comorbid diseases such as CV and diabetes.…”

Section: Herbal Treatment For Ed (Yohimbine)mentioning

confidence: 99%

“…On the other hand, the herbal or traditional therapeutic approach may be more culturally acceptable with some patients, who may prefer this holistic option because of religious, social, monetary or other personal preferences. As a result, there is a growing interest among the population for alternative holistic treatment options, which has increased demand for such therapies in the United States [44]. Though there are many herbal remedies available at present for ED, this review will focus on the efficacy of yohimbine.…”

Section: Herbal Treatment For Ed (Yohimbine)mentioning

confidence: 99%