Risiken perioperativer Benzodiazepin-Abhängigkeit beim alten Menschen – was der Chirurg hierzu wissen sollte

Brinkers, Michael; Pfau, Giselher; Schilling, Tobias; Meyer, Frank

doi:10.1055/s-0041-107198

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…Converting BDZs into an equivalent dose of diazepam (EDD) is common in clinical practice and useful in BDZ withdrawal. There is often a range rather than a unique value for a specific BDZ, for example, 10 mg of diazepam is equivalent to 20–50 mg of tetrazepam, yet there is no standard conversion table, and diazepam dose equivalence tables can only be found in some of the articles using the EDD method (e.g., Alexander & Perry, 1991 ; Brinkers et al., 2016 ; Kaendler et al., 1996 ).…”

Section: Discussionmentioning

confidence: 99%

Benzodiazepine high‐doses: The need for an accurate definition

Cloos¹,

Cow²,

Bocquet

2021

Int J Methods Psych Res

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Objectives A clear definition of what we understand of high‐dose misuse or of a ‘markedly increased dose’ (as stated by the DSM‐5) is important and past definitions may be inadequate. The aim of this review is to describe the different definitions used and to test these definitions for their accuracy. Methods A narrative PubMed literature review was conducted based on articles published between 1 January 1990 and 31 December 2020 describing benzodiazepines (in MeSH Terms or MeSH Major Topic) and high‐dose (or high‐dosage). Specific definitions were applied to a population sample to show how definitions affect high‐dose benzodiazepine prevalence. Results Multiples of an equivalent‐diazepam dose or of the World Health Organization ‘defined daily dosage’ were used more frequently than the overstep of the recommended maximum therapeutic dosage as a cut‐off point. Conclusion High‐dose use is rare but the prevalence in the general population varies among studies, mainly due to different definitions, making both clinical and epidemiological comparisons between studies difficult. Defining a high‐dose user as a person who takes at least a higher dose than the maximum usual therapeutic dose over a defined period of time therefore appears to be clinically more consistent.

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Section: Discussionmentioning

confidence: 99%

Benzodiazepine high‐doses: The need for an accurate definition

Cloos¹,

Cow²,

Bocquet

2021

Int J Methods Psych Res

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Clinical consequences of abuse and misuse of hypnotics and analgesics in geriatric population

Trawka

Husejko

Kędziora–Kornatowska

2021

Ból

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Insomnia and pain coexist with chronic diseases, especially in the elderly, who are therefore the largest group taking hypnotics and analgesics. For this reason, seniors are at high risk of abusing these medications, leading to dangerous and unpredictable clinical outcomes. The article provides a literature review using the Pubmed, Medline, Embase and Google Scholar databases. The articles were analysed using the following keywords: drug abuse, sleeping pills, painkillers, benzodiazepines, opioids. The article presents the characteristics of medical substances belonging to sleeping pills and painkillers, taking into account the consequences of their misuse. Hypnotics and pain relievers, especially benzodiazepines and opioids, are the most abused drug classes in the elderly. In the case of hypnotics, apart from benzodiazepines, these are zolpidem and zopiclone or trazodone, and in the case of analgesics, codeine, tramadol, morphine or oxycodone and also paracetamol and NSAIDs. The problem of abuse and misuse of hypnotics and analgesics in the geriatric population is still growing and therefore more and more attention should be paid to this problem. Although this type of treatment is important to maintain a good quality of life for the elderly, proper education among staff, patients and their carers is also needed. Proper information provided by medical personnel plays an important role in this matter.

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Risiken perioperativer Benzodiazepin-Abhängigkeit beim alten Menschen – was der Chirurg hierzu wissen sollte

Abstract: For the intake and continuous prescription there are four basic rules:Well-defined indication, correct dosage, short application, no sudden discontinuation.

Cited by 2 publications

References 29 publications

Benzodiazepine high‐doses: The need for an accurate definition

Benzodiazepine high‐doses: The need for an accurate definition

Clinical consequences of abuse and misuse of hypnotics and analgesics in geriatric population

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