Rising incidence of early-onset colorectal cancer — a call to action

Akimoto, Naohiko; Ugai, Tomotaka; Zhong, Rong; Hamada, Tsuyoshi; Fujiyoshi, Kenji; Giannakis, Marios; Wu, Kana; Cao, Yin; Ng, Kimmie; Ogino, Shuji

doi:10.1038/s41571-020-00445-1

Cited by 387 publications

(354 citation statements)

References 168 publications

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“…It showed prognostic significance for progression-free survival on univariate analysis only. Existing literature suggests variable prognostic importance [ 39 ]. The last four decade has noticed a significant rise in the incidence and mortality of EOCRC globally [ 3 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…The last four decade has noticed a significant rise in the incidence and mortality of EOCRC globally [ 3 , 40 ]. EOCRC cancers are comparatively rich in MSI-high status (11–30%), left-sided (73%, especially rectum), risk of synchronous and metachronous tumors, germline mutations(16–35%), signet ring morphology (3–6%), and lynch syndrome (8–18%) [ 39 , 41 , 42 ]. Signet ring morphology and MSI-high status are associated with poor outcomes [ 39 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…EOCRC cancers are comparatively rich in MSI-high status (11–30%), left-sided (73%, especially rectum), risk of synchronous and metachronous tumors, germline mutations(16–35%), signet ring morphology (3–6%), and lynch syndrome (8–18%) [ 39 , 41 , 42 ]. Signet ring morphology and MSI-high status are associated with poor outcomes [ 39 , 42 ]. In our study cohort, three fourth of signet ring CRC occurred in the EOCRC sub-group.…”

Section: Discussionmentioning

confidence: 99%

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Metastatic colo-rectal cancer: real life experience from an Indian tertiary care center

Sharma

Raina

et al. 2021

BMC Cancer

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Background No data exist for the long-term outcome of metastatic colorectal cancer (mCRC) from the Southern part of Asia. The primary objective of the study is to evaluate the survival outcome of mCRC from an Indian tertiary care center. The study also aims to highlight the treatment pattern practiced and the unique clinico-pathologic characteristics. Methods This is a single-center retrospective observational study done at a large referral tertiary care center in North India. All patients with synchronous or metachronous mCRC who received at least one dose of chemotherapy for metastatic disease, registered between 2003 to 2017 were included. Primary outcome measures were overall survival and progression-free survival and prognostic factors of overall survival. Descriptive analysis was done for the clinicopathological characteristics and treatment patterns. Kaplan Meier method for overall survival and progression-free survival. Cox regression analysis was performed for the determination of the prognostic factors for overall survival. Result Out of 377 eligible patients, 256 patients (68%) had de novo metastatic disease and the remaining 121 (32%) progressed to metastatic disease after initial treatment. The cohort was young (median age, 46 years) with the most common primary site being the rectum. A higher proportion of signet (9%) and mucinous histology (24%). The three common sites of metastasis were the liver, peritoneum, and lung. In the first line, most patients received oxaliplatin-based chemotherapy (70%). Only 12.5% of patients received biologicals in the first-line setting. The median follow-up and median overall survival of study cohort were 17 months and 18.5 months. The factors associated with poor outcome for overall survival on multivariate analysis were ECOG performance status of > 1, high CEA, low albumin, and the number of lines of chemotherapy received (< 2). Conclusion The outcome of mCRC is inferior to the published literature. We found a relatively higher proportion of patients with the following characteristics; younger, rectum as primary tumor location, the signet, and mucinous histology, higher incidence of peritoneum involvement. The routine use of targeted therapies is limited. Government schemes (inclusion of targeted therapies in the Ayushman scheme), NGO assistance, and availability of generic low-cost targeted drugs may increase the availability.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Metastatic colo-rectal cancer: real life experience from an Indian tertiary care center

Sharma

Raina

et al. 2021

BMC Cancer

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“…Colorectal cancer (CRC) is at the third rank in term of incidence and at the second rank in term of mortality [ 1 ]. The incidence of CRC is country-dependent and the main factor risks for CRC are family hereditary, red and processed meat consumption, alcohol drinking, obesity, and inflammatory bowel disease [ 9 ]. Surprisingly, while the overall incidence and mortality are decreasing, the incidence of early-onset CRC, generally diagnosed before 50 years old, is increasing worldwide.…”

Section: Introductionmentioning

confidence: 99%

“…Surprisingly, while the overall incidence and mortality are decreasing, the incidence of early-onset CRC, generally diagnosed before 50 years old, is increasing worldwide. The increase in early-onset CRC incidence associated with a higher mortality rate for young adults may be associated with Western lifestyle, including diet [ 9 ]. Consequently, there is an important role of nutrition in cause and prevention of CRC [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Mg2+ Transporters in Digestive Cancers

et al. 2021

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Despite magnesium (Mg2+) representing the second most abundant cation in the cell, its role in cellular physiology and pathology is far from being elucidated. Mg2+ homeostasis is regulated by Mg2+ transporters including Mitochondrial RNA Splicing Protein 2 (MRS2), Transient Receptor Potential Cation Channel Subfamily M, Member 6/7 (TRPM6/7), Magnesium Transporter 1 (MAGT1), Solute Carrier Family 41 Member 1 (SCL41A1), and Cyclin and CBS Domain Divalent Metal Cation Transport Mediator (CNNM) proteins. Recent data show that Mg2+ transporters may regulate several cancer cell hallmarks. In this review, we describe the expression of Mg2+ transporters in digestive cancers, the most common and deadliest malignancies worldwide. Moreover, Mg2+ transporters’ expression, correlation and impact on patient overall and disease-free survival is analyzed using Genotype Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) datasets. Finally, we discuss the role of these Mg2+ transporters in the regulation of cancer cell fates and oncogenic signaling pathways.

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US Preventive Services Task Force Recommendations for Colorectal Cancer Screening

May

Schrag

2021

JAMA

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Rising incidence of early-onset colorectal cancer — a call to action

Abstract: all of which are described at www.genenames.org. Gene symbols are italicized whereas symbols for gene products are not italicized.

Cited by 387 publications

References 168 publications

Metastatic colo-rectal cancer: real life experience from an Indian tertiary care center

Metastatic colo-rectal cancer: real life experience from an Indian tertiary care center

Mg2+ Transporters in Digestive Cancers

US Preventive Services Task Force Recommendations for Colorectal Cancer Screening

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