Rising Incidence of Mucosal Melanoma of the Head and Neck in the United States

Marcus, David M.; Marcus, Rebecca P.; Prabhu, Roshan S.; Owonikoko, Taofeek K.; Lawson, David H.; Switchenko, Jeffrey M.; Beitler, Jonathan J.

doi:10.1155/2012/231693

Cited by 67 publications

(61 citation statements)

References 25 publications

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“…Our results are consistent with a Dutch epidemiological study from 2010 with 261 cases of MMHN obtained in the period 1989-2006, which found no significant changes in the incidence of MMHN over time [16]. Two other recent studies, a Swedish study from 2013 [5] and an American study from 2012 [2], showed a significant increase in incidence for sinonasal MM during the study periods, which were 1960-2000 with 186 sinonasal MM cases and 1987-2009 with 452 MMHN cases, respectively. Both studies found a higher incidence of sinonasal MM in women.…”

Section: Discussionsupporting

confidence: 92%

“…Although melanocytes in the mucosal layers of the head and neck are thought to be histologically identical to melanocytes in the skin [1], the pathogenesis of MM-including MMHN-is unknown. Several etiological agents have been proposed for MMHN, including the use of tobacco and occupational exposure to inhaled carcinogens, but the results are inconclusive [2].…”

mentioning

confidence: 99%

“…Other sites include the gastrointestinal tract, the genitourinary tract, and the meninges [3]. Only a few population-based studies have examined the incidence of MMHN [2][3][4][5] and no uniform trends in incidence have been found. Different staging systems for MM have been proposed and used.…”

mentioning

confidence: 99%

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Primary mucosal melanoma of the head and neck in Denmark, 1982–2012: Demographic and clinical aspects. A retrospective DAHANCA study

et al. 2016

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Background The study was performed to determine the epidemiological, clinical, and histopathological characteristics and prognosis of primary mucosal melanoma of the head and neck (MMHN) in Denmark. Material and methods This was a national retrospective multicenter study of patients diagnosed with MMHN between 1982 and 2012 in Denmark. Data were retrieved from national databases and patient records. Incidence trends were examined for the entire period. We prepared survival curves and performed univariate and multivariate analysis for the period 1992-2012 to identify possible prognostic factors. Results No significant trends in incidence were found in the study period. The three-year overall and disease-free survival rates for MMHN were 46.5% and 35.5%, respectively. Negative margins was an independent predictor of disease-free survival, and age below 65, absence of distant metastases, and low overall TNM stage were predictors of overall survival. Radiotherapy did not improve survival significantly. Recurrence rates were high, even for patients with negative margins. Conclusions MMHN remains a rare disease with a poor prognosis, particularly for patients aged over 65, those with distant metastasis, and those with advanced TNM stage. Importantly, the rate of recurrence is lowest in patients with negative margins.

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Section: Discussionsupporting

confidence: 92%

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confidence: 99%

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Primary mucosal melanoma of the head and neck in Denmark, 1982–2012: Demographic and clinical aspects. A retrospective DAHANCA study

et al. 2016

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“…However, when comparing incidence data from 1960 and 2010, SCC was still the most frequent tumour followed by SNMM, which was rare in 1960. This increase in the incidence of SNMM has recently been observed in other studies (2,13,14) . The differences in distribu- diagnosis.…”

Section: Discussionsupporting

confidence: 81%

Sinonasal malignancies in Sweden 1960-2010; a nationwide study of the Swedish population

Elliot¹,

Jangard²,

Marklund³

et al. 2015

Rhin

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“…2,3 In a study carried out by Marcus, 452 cases of HNMM of the Surveillance, Epidemiology, and End Results (SEER) 9 registry of the United States between 1987 and 2009, were identified. 4 According to this study, the incidence of HNMM in the United States has been rising since 1987. This trend has been driven primarily by increased incidence of nasal cavity melanomas.…”

Section: Introductionmentioning

confidence: 83%

Sinonasal mucosal melanomas in Quito, Ecuador

Pacheco-Ojeda¹

2017

Int Surg J

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Background: Head and neck mucosal melanoma account for 2 to 8% of head and neck melanomas, the majority of which arises in the nasal cavity or paranasal sinuses. The aim of this report was to review our experience on sinonasal malignant melanomas (SNMM) treated over a long period of time at a tertiary referral hospital.Methods: Clinical records of all of the patients operated on for SNMM at the Social Security Hospital and private clinics in Quito, Ecuador, were reviewed. Nineteen patients had histologically proven diagnosis. Eleven patients were men and mean age was 64. The most common presenting symptoms were nasal obstruction and epistaxis. Most tumors were located at the nasal fossa. Extranasal extension was present in 11 patients. Twelve had stage III- IV tumors. All patients were treated by surgery. Postoperative radiotherapy was given to 7.Results: Local recurrence (11 events) occurred in 9 cases. These 11 events were treated with surgery in 8, eventually associated to radiation therapy (RT) and chemotherapy (CT). Eight out of these 9 patients died. Five overall survival was 46%. Death was related to local disease and distant metastases. All stage I tumor patients are alive.Conclusions: Most sinunasal melanomas have a poor prognosis, mainly attributed to initial advanced local disease, local recurrence and distant metastasis. Surgery is the mainstay treatment, followed by radiotherapy, according to the T category.

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Rising Incidence of Mucosal Melanoma of the Head and Neck in the United States

Cited by 67 publications

References 25 publications

Primary mucosal melanoma of the head and neck in Denmark, 1982–2012: Demographic and clinical aspects. A retrospective DAHANCA study

Primary mucosal melanoma of the head and neck in Denmark, 1982–2012: Demographic and clinical aspects. A retrospective DAHANCA study

Sinonasal malignancies in Sweden 1960-2010; a nationwide study of the Swedish population

Sinonasal mucosal melanomas in Quito, Ecuador

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