Rising Incidence of Small Size Papillary Thyroid Cancers with No Change in Disease-Specific Survival in Finnish Thyroid Cancer Patients

Abstract

Background: the aim of this study was to investigate trends in the incidence, diagnostics, treatment and survival of thyroid cancer in tampere university hospital (tauh) region in recent decades.Material and Methods: new thyroid cancer cases from 1981 to 2002 were ascertained from the finnish cancer Registry. follow-up data was collected from medical records of tauh. differentiated thyroid cancer (dtc; consisting of papillary thyroid cancer (ptc) and follicular thyroid cancer (ftc)) patients' data was analyzed and divided into two equal time periods (1981-1991 and 1992-2002).Results: the total amount of thyroid cancer cases was 553, of which 427 (77%) were papillary and 72 (13%) follicular. thyroid cancer was four times more common in females than in males and the median age at the time of diagnosis was 52 years. the incidence of dtc was 4.5/100 000 in the earlier group and 6.0/100 000 in the later group (iRR 1.33, ci 1.11-1.60). the proportion of papillary thyroid cancer rose from 81% to 89% (p = 0.02) in two study periods. median tumour size became smaller, from 25 mm to 15 mm (p < 0.001). surgery became more radical as total thyroidectomies were performed almost exclusively on the later group (p < 0.001). median cumulative dose of radioiodine (i 131 ) therapy was higher in the later group (p = 0.04). there was no difference in number of cancer recurrences (p = 0.54). the prognosis of dtc was good; 10-year diseasespecific survival was 92% in the earlier group and 94% in the later group (p = 0.43).Conclusions: the incidence of thyroid cancer has risen and proportion of papillary cancer has increased, however, median size of tumour has decreased. no difference was seen in either all-cause or disease-specific survival.

Histopathological Patterns of Thyroid Disease in Al-Madinah Region of Saudi Arabia

“…In addition to being consistent with the hospital based histopathological studies that papillary carcinoma is the commonest malignancy of thyroid and its frequency is increasing. Our findings also conform to the recent registry based studies from Finland (Hakala et al, 2012) and Wales (Amphlett et al, 2013); regarding the increasing trend of papillary carcinoma in Europe. Wang et al, (2013) in their study found incidental papillary carcinoma in 147 out of their 709 cases and concluded that these are more common in females.…”

“…From Turkey, Veyseller et al (2009), looked into thyroidectomies for benign diseases, while Yildiz et al (2014), studied the rising trends of papillary carcinoma of thyroid. Recent registry based studies are also available from Finland (Hakala et al, 2012) and Switzerland (Rapiti et al, 2014).…”

A core needle biopsy provides more malignancy-specific results than fine-needle aspiration biopsy in thyroid nodules suspicious for malignancy

“…Intraoperative FNA and CNB samples were taken and compared with the final pathological diagnosis. The mean age of our patients was 53 years, which is slightly higher than the age of the typical thyroid cancer patient population in our hospital region 27. Most tumours were located in the right lobe and were externally palpable.…”

The Clinicopathological Factors Associated with Multicentricity in Papillary Thyroid Cancer

“…Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, accounting for 70% to 80% of all thyroid cancers [2]. These cancers originate in the follicular cells of the thyroid gland and generally have a good prognosis if properly treated.…”